Antioxidant and In Vitro Anticancer Effect of 2‐Pyrrolidinone Rich Fraction of Brassica oleracea var. capitata Through Induction of Apoptosis in Human Cancer Cells

Thangam, Ramar; Suresh, Veeraperumal; Rajkumar, Mayan; Vincent, Jally Damien; Gunasekaran, Palani; Anbazhagan, C.; Krishnasamy, Kaveri; Kannan, Soundarapandian

doi:10.1002/ptr.4908

Cited by 36 publications

(21 citation statements)

References 21 publications

(28 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A further protective effect of Brassicaceae is represented by the inhibition of mechanisms regulating the development of cancer. Indeed, a 2-pyrrolidinone rich extract from Brassica oleracea showed in vitro cytotoxicity on HeLa and PC-3 human cancer cell lines, and it also exhibited antioxidant activity in a cell-free system [ 39 ]. Adverse effects of compounds that are present in Brassicaceae towards metabolic syndromes are also possible.…”

Section: Bioactive Compounds In Brassicaceae Anmentioning

confidence: 99%

Bioactive Compounds in Brassicaceae Vegetables with a Role in the Prevention of Chronic Diseases

et al. 2017

View full text Add to dashboard Cite

The beneficial role of the Mediterranean diet in the prevention of chronic diseases, including cardiovascular diseases, diabetes, and obesity, is well-recognized. In this context, Brassicaceae are considered important vegetables due to several evidences of their health promoting effects that are associated to bioactive compounds present in the edible parts of the plants. In this review, the mechanisms of action and the factors regulating the levels of the bioactive compounds in Brassicaceae have been discussed. In addition, the impact of industrial and domestic processing on the amount of these compounds have been considered, in order to identify the best conditions that are able to preserve the functional properties of the Brassicaceae products before consumption. Finally, the main strategies used to increase the content of health-promoting metabolites in Brassica plants through biofortification have been analyzed.

show abstract

Section: Bioactive Compounds In Brassicaceae Anmentioning

confidence: 99%

Bioactive Compounds in Brassicaceae Vegetables with a Role in the Prevention of Chronic Diseases

et al. 2017

View full text Add to dashboard Cite

show abstract

“…These include: 9, 12-octadecadienoic acid (Z,Z)-(0.83%), a conjugated linoleic acid reported to occur in an ethanolic extract of Phragmytes vallatoria leaves; 32 2-pyrrolidinone (0.38%), reported in Brassica oleraceae var. capitata; 33 Vitamin-E (0.32%), a potential antioxidant that protects the cell against free radicals; 28,31 hexadecanoic acid methyl ester (0.23%), that has been detected in the methanolic fraction of Aegle marmelos 31 and a well-reported antioxidant compound, retinol (0.17%), that inhibits lipid peroxidation. 34 Thus, 11% of the phytoconstituents identified in the ethanolic extract of T. divaricata leaves in the current study have previously been reported to exhibit antioxidant activity.…”

Section: Discussionmentioning

confidence: 99%

Gas Chromatography - Mass Spectrometry Analysis and In vitro Antioxidant Activity of the Ethanolic Extract of the Leaves of Tabernaemontana divaricata

Anbukkarasi¹,

Thomas²,

Sundararajan³

et al. 2016

Phcogj

View full text Add to dashboard Cite

Objective: To identify phytoconstituents present in an ethanolic extract of the leaves of Tabernaemontana divaricata and to evaluate its in-vitro antioxidant potential. Methods: The extract was subjected to gas chromatography-mass spectrometry analysis to identify phytoconstituents, and screened for hydroxyl, superoxide and 1, 1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity, reducing power and metal-chelating activity as a measure of potential antioxidant activity. Results: GC-MS analysis of the extract revealed the presence of 96 phytoconstituents, of which 17 are reported to be bioactive and 11 of these to possess antioxidant potential. When tested in-vitro, the extract exhibited the most potent radical-scavenging activity at a maximum concentration of 10 mg/ml, scavenging effects of 64%, 67% and 69% and corresponding half maximal inhibitory concentration (IC 50 ) values of 6.7 mg/ml, 6.8 mg/ml and 6.2 mg/ml on hydroxyl, superoxide and DPPH radicals, respectively. Ascorbic acid used as a standard (10 mg/ml) showed scavenging effects of 73%, 73% and 75% and corresponding IC 50 values of 5.3 mg/ml, 5.8 mg/ml and 5.2 mg/ml, respectively, on hydroxyl, superoxide and DPPH radicals. At 10 mg/ml, the extract and an ethylenediaminetetraacetic acid standard exhibited 68% and 78%, respectively, chelation of ferrous ions; at the same concentration, the reducing power of the extract and that of a butylated hydroxytoluene standard was found to be 3.855 and 4.308, respectively. Conclusion: These observations strongly suggest that the ethanolic extract of T. divaricata leaves has potent in-vitro antioxidant activity and thereby could act as a possible therapeutic agent for oxidative stressinduced pathological states.

show abstract

“…The hypocholesterolemic effect of eggplant has been well documented in addition to its rich content of iron, calcium, potassium, phosphorus, and vitamin B complex [82,83]. Broccoli is a good source of quercetin, sulforaphane, and polyphenolic antioxidants, and may offer help in reducing cholesterol and regulating insulin [84][85][86]. Carrot, usually eaten raw or as a cooked vegetable, may be artery protecting, immunomodulating, and hypocholesterolemic [87,88].…”

Section: Rosmentioning

confidence: 99%

Cardiovascular Diseases: Can Herb-Based Antioxidant and Anti-Inflammatory Functional Products Be a Solution?

Rahal

Kumar

2016

ROS

View full text Add to dashboard Cite

Cardiovascular health is vital for maintenance of life in man as well as animals. Inflammatory changes in the cardiovascular system are a common occurrence with today's lifestyle, but they generally go unnoticed unless they appear as a severe life-threatening clinical manifestation. The major cardiovascular risk revolves around three pathophysiological events, namely, oxidation of low-density lipoproteins, endothelial dysfunction, and release of inflammatory mediators. The effective management of cardiovascular diseases largely aims at reducing/delaying symptoms or affecting hemodynamic response and often does not affect the cause or course of disease, namely, the atherosclerotic lesion itself. Several Indian herbs carry tremendous restorative potential and can be successfully employed to achieve the therapeutic targets. Public awareness of the health benefits of herbs has motivated the common man to incorporate many of these in their dietary schedule, but many times their interactions result in serious clinical outcomes, which are generally misunderstood as side effects of medicines being prescribed by the physicians. Therefore, it becomes mandatory that the pharmacological role of the herbs used as spices and regular dietary ingredient or supplement be earmarked and judiciously used for promoting the health of the mankind. In this review, the much recommended use of herbal components as prophylactic functional foods is discussed with respect to the health benefits likely to be offered in cardiovascular issues and the threats imposed through them.

show abstract

Antioxidant and In Vitro Anticancer Effect of 2‐Pyrrolidinone Rich Fraction of Brassica oleracea var. capitata Through Induction of Apoptosis in Human Cancer Cells

Cited by 36 publications

References 21 publications

Bioactive Compounds in Brassicaceae Vegetables with a Role in the Prevention of Chronic Diseases

Bioactive Compounds in Brassicaceae Vegetables with a Role in the Prevention of Chronic Diseases

Gas Chromatography - Mass Spectrometry Analysis and In vitro Antioxidant Activity of the Ethanolic Extract of the Leaves of Tabernaemontana divaricata

Cardiovascular Diseases: Can Herb-Based Antioxidant and Anti-Inflammatory Functional Products Be a Solution?

Contact Info

Product

Resources

About