Antioxidant and hepatoprotective effects of purified Rhodiola rosea polysaccharides

Xu, Yao; Jiang, Huiyan; Sun, Congyong; Adu‐Frimpong, Michael; Deng, Wenwen; Yu, Jiangnan; Xu, Ximing

doi:10.1016/j.ijbiomac.2018.05.168

Cited by 52 publications

(28 citation statements)

References 30 publications

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“…As previously reported, the polysaccharides with a helical conformation could give rise to a bathochromic shift of the maximum absorption λ of the Congo red-polysaccharide complex, in comparison with pure Congo red (Xu et al, 2018). The absorptions of Congo red-SMP-1 complex and pure Congo red were determined at various NaOH concentrations.…”

Section: Congo Red Testmentioning

confidence: 68%

Structural characterization and hypolipidemic activities of purified stigma maydis polysaccharides

Deng

Yang

Zhu

et al. 2019

Food Science & Nutrition

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This study aimed to investigate structural features and antihyperlipidemic effects of the stigma maydis polysaccharide, termed SMP‐1. This polysaccharide was composed of D‐mannose, L‐rhamnose, D‐glucose, D‐galactose, L‐arabinose, D‐xylose, and D‐galacturonic acid, with a molar ratio of 1.00:0.21:1.41:1.44:0.70:0.44:0.56. The SMP‐1 was mainly bonded by (1 → 6) and (1 → 3) linkages, with various monosaccharides being evenly distributed in the main and side chains. Moreover, SMP‐1 had neither triple‐helical structure nor molecular aggregation. Importantly, the SMP‐1 could effectively bind the bile acids in vitro and significantly lower the total cholesterol, triglyceride, low‐density lipoprotein cholesterol levels, and moderately increase the high‐density lipoprotein cholesterol level in poloxamer 407‐induced hyperlipidemic mice. Moreover, pretreatment with SMP‐1 (≥300 mg/kg) could remarkably reduce fat accumulation and restore hepatocyte morphology in the liver of hyperlipidemic mice. Altogether, these findings indicated that SMP‐1 could be developed as a safe and effective food supplement for preventing and treating hyperlipidemic disorders.

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Section: Congo Red Testmentioning

confidence: 68%

Structural characterization and hypolipidemic activities of purified stigma maydis polysaccharides

Deng

Yang

Zhu

et al. 2019

Food Science & Nutrition

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“…It is known that golden root has an excellent immunoregulatory effect and weakens inflammatory damage in various diseases by regulating the differentiation of immune cells, activating inflammatory signaling pathways and secreting inflammatory factors [ 87 , 88 , 89 ]. Polysaccharides isolated from the rhizomes and roots of Rhodiola rosea have antioxidant, antiviral and antitumor activity and are widely used in traditional Chinese medicine [ 90 , 91 , 92 ]. Active compounds (salidroside, tyrosol, ferulic acid, kaempferol, Gallic acid, catechin and phenethyl ether of caffeic acid, etc.)…”

Section: Resultsmentioning

confidence: 99%

Medicinal Plants to Strengthen Immunity during a Pandemic

et al. 2020

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The development of new effective anti-coronavirus drugs and therapies is important, but it requires significant human, financial and, most importantly, time expenditures. The current pandemic is neither the first nor the last. Humanity has already accumulated considerable survival experience. We cannot do without prevention and epidemiological protection measures. This study reviews medicinal plants that grow in Northeast Asia and whose antioxidant, antiviral, anti-inflammatory and immunomodulatory characteristics are already known, also in the framework of the prevention and treatment of pneumonia of various etiologies. The need for a comprehensive approach to maintaining immunodefences, including functional foods and positive emotions, is emphasized. In the period of pandemics, it is important to research various areas that allow to us accumulate a critical mass of information and cope with the next global disease.

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“…The NC and MC groups were given water through intragastric route, while the PC group received silibinin (100 mg/kg per day suspended in 0.5% CMC‐Na). The mice in the FC, CS and BS groups were each treated with 200 mg/kg per day (based on previous report and preliminary study data not shown) of free cuminaldehyde, CuA‐SEN and blank SEN with all samples dispersed in DDW, respectively, for 7 consecutive days on the account of earlier works . ELISA kits were used to determine the biochemical markers, viz.…”

Section: Methodsmentioning

confidence: 99%

“…The mice in the FC, CS and BS groups were each treated with 200 mg/kg per day (based on previous report [12] and preliminary study data not shown) of free cuminaldehyde, CuA-SEN and blank SEN with all samples dispersed in DDW, respectively, for 7 consecutive days on the account of earlier works. [65,66] ELISA kits were used to determine the biochemical markers, viz. ALT, AST, CAT GSH, MDA, SOD TNF-a and IL-6 (for other details refer to Appendix S1).…”

Section: In-vivo Evaluation Of Antioxidation Anti-inflammation and Amentioning

confidence: 99%

Novel cuminaldehyde self-emulsified nanoemulsion for enhanced antihepatotoxicity in carbon tetrachloride-treated mice

Adu‐Frimpong

Wei

Firempong

et al. 2019

Journal of Pharmacy and Pharmacology

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Objectives Cuminaldehyde self‐emulsified nanoemulsion (CuA‐SEN) was prepared and optimised to improve its oral bioavailability and antihepatotoxicity. Methods Cuminaldehyde self‐emulsified nanoemulsion was developed through the self‐nanoemulsification method using Box–Behnken Design (BBD) tool while appropriate physicochemical indices were evaluated. The optimised CuA‐SEN was characterised via droplet size (DS), morphology, polydispersity index (PDI), zeta potential (ZP), entrapment efficiency, in‐vitro release, and pharmacokinetic studies while its antihepatotoxicity was evaluated. Key findings Cuminaldehyde self‐emulsified nanoemulsion with acceptable characteristics (mean DS‐48.83 ± 1.06 nm; PDI‐0.232 ± 0.140; ZP‐29.92 ± 1.66 mV; EE‐91.51 ± 0.44%; and drug‐loading capacity (DL)‐9.77 ± 0.75%) was formulated. In‐vitro drug release of CuA‐SEN significantly increased with an oral relative bioavailability of 171.02%. Oral administration of CuA‐SEN to CCl4‐induced hepatotoxicity mice markedly increased the levels of superoxide dismutase, glutathione and catalase in serum. Also, CuA‐SEN reduced the levels of tumour necrosis factor‐alpha and interleukin‐6 in both serum and liver tissues while aspartate aminotransferase, alanine aminotransferase and malonaldehyde levels were significantly decreased. Conclusions These findings showed that the improved bioavailability of cuminaldehyde via SEN provided an effective approach for enhancing antioxidation, anti‐inflammation and antihepatotoxicity of the drug.

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Antioxidant and hepatoprotective effects of purified Rhodiola rosea polysaccharides

Cited by 52 publications

References 30 publications

Structural characterization and hypolipidemic activities of purified stigma maydis polysaccharides

Structural characterization and hypolipidemic activities of purified stigma maydis polysaccharides

Medicinal Plants to Strengthen Immunity during a Pandemic

Novel cuminaldehyde self-emulsified nanoemulsion for enhanced antihepatotoxicity in carbon tetrachloride-treated mice

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