Antioxidant and electrochemical properties of calcium and lithium ascorbates

Avramchik, O. A.; Короткова, Е. И.; Plotnikov, Evgenii; Lukina, Anna N.; Karbainov, Yu. A.

doi:10.1016/j.jpba.2004.11.016

Cited by 23 publications

(14 citation statements)

References 16 publications

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“…Antioxidant activity of the HA samples was evaluated by measuring the electrochemical reduction current of O 2 at a mercury film electrode after reaction of the compounds with O 2 ·− [ 53 , 68 ]. A phosphate buffer solution (pH 6.9) served as the supporting electrolyte.…”

Section: Methodsmentioning

confidence: 99%

Physicochemical Characterization and Antioxidant Activity of Humic Acids Isolated from Peat of Various Origins

et al. 2018

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Although humic acids (HAs) from peat exhibit various therapeutic properties, there is little information available concerning their physicochemical and antioxidant properties. To address this issue, nine different types of peat, including oligotrophic, mesotrophic, and minerotrophic peat samples, were used for isolation of HA fractions by basic (HAb) and pyrophosphate (HAp) extractions. Physical parameters of the HAs were analyzed by UV-Vis, fluorescent, infrared (IR), and electron paramagnetic resonance (EPR) spectroscopy. Average Mr of the fractions ranged from 17.2 to 39.7 kDa, while their humification index (HIX) varied from 0.49 to 1.21. HAp fractions had a higher content of aromatic structures compared to HAb fractions. Moreover, HAp fractions had a significantly higher content of phenolic OH groups (3.6 ± 0.5 mmol/g) versus HAb (3.1 ± 0.5 mmol/g). All HA fractions exhibited antioxidant activity in radical scavenging and electrochemical assays, and their EPR signal had a single line with g = 2.0035, which is consistent with semiquinone type radicals. Furthermore, the HIX was found to be important in determining the number of semiquinone-type free radicals in the HA structures. Overall, these data provide a molecular basis to explain at least part of the beneficial therapeutic properties of peat-derived HAs.

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Section: Methodsmentioning

confidence: 99%

Physicochemical Characterization and Antioxidant Activity of Humic Acids Isolated from Peat of Various Origins

et al. 2018

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“…and connected with a number of biochemical processes in a human organism [ 1 , 2 ]. In recent studies of the effect of pathogenic factors and drugs (including alcohol) on body’s antioxidant system and the ability to reduce these effects by administering antioxidants is gaining importance [ 3 , 4 , 5 , 6 , 7 , 8 , 9 ]. Thus a detailed research of total antioxidant activity (TAA) of human serum blood under physiological and pathological conditions (alcoholism) and TAA possible dependence of antioxidant therapy efficiency is highly prospective.…”

Section: Introductionmentioning

confidence: 99%

Study of Total Antioxidant Activity of Human Serum Blood in the Pathology of Alcoholism

et al. 2013

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The total antioxidant activity (TAA) of human serum blood of patients suffering from alcoholism was tested by cathode voltammetry with a model process of oxygen electroreduction. A known spectrophotometrical method was used for comparison. As results the total antioxidant activity of serum blood of patients with alcoholism was estimated by voltammetry during therapy in hospital. It was shown the TAA of serum blood of patients in pathology before and after treatment is lower than that one of healthy people. However, during the process of 10 days of alcoholism treatment the TAA coefficient increases. The relationship between the coefficient of total antioxidant activity of human serum blood and the stage of treatment was detected.

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“…It is well known that mental illnesses significantly affect the antioxidant protective system of an organism which might lead to oxidative damage caused by a rapid growth of free oxygen radicals [ 8 – 15 ]. Thus a detailed research of oxygen radical’s quantity in human serum blood under pathological conditions (schizophrenia) and the investigation of its possible correlation with antioxidant therapy efficiency is highly prospective.…”

Section: Introductionmentioning

confidence: 99%

Study of OH● Radicals in Human Serum Blood of Healthy Individuals and Those with Pathological Schizophrenia

Короткова

Misini

Dorozhko

et al. 2011

IJMS

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The human body is constantly under attack from free radicals that occur as part of normal cell metabolism, and by exposure to environmental factors such as UV light, cigarette smoke, environmental pollutants and gamma radiation. The resulting “Reactive Oxygen Species” (ROS) circulate freely in the body with access to all organs and tissues, which can have serious repercussions throughout the body. The body possesses a number of mechanisms both to control the production of ROS and to cope with free radicals in order to limit or repair damage to tissues. Overproduction of ROS or insufficient defense mechanisms leads to a dangerous disbalance in the organism. Thereby several pathomechanisms implicated in over 100 human diseases, e.g., cardiovascular disease, cancer, diabetes mellitus, physiological disease, aging, etc., can be induced. Thus, a detailed investigation on the quantity of oxygen radicals, such as hydroxyl radicals (OH•) in human serum blood, and its possible correlation with antioxidant therapy effects, is highly topical. The subject of this study was the influence of schizophrenia on the amount of OH• in human serum blood. The radicals were detected by fluorimetry, using terephthalic acid as a chemical trap. For all experiments the serum blood of healthy people was used as a control group.

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Antioxidant and electrochemical properties of calcium and lithium ascorbates

Cited by 23 publications

References 16 publications

Physicochemical Characterization and Antioxidant Activity of Humic Acids Isolated from Peat of Various Origins

Physicochemical Characterization and Antioxidant Activity of Humic Acids Isolated from Peat of Various Origins

Study of Total Antioxidant Activity of Human Serum Blood in the Pathology of Alcoholism

Study of OH● Radicals in Human Serum Blood of Healthy Individuals and Those with Pathological Schizophrenia

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