Antioxidant and antitumor activities of water extracts from the root of Actinidia kolomikta

Abstract

Abstract. the genus of Actinidia is widely distributed throughout the Asian continent. Specific Actinidia species have been used as health foods and medical products for cancer treatment. Actinidia kolomikta is a species of wild plant that grows in the northern part of indochina. however, few studies on its bioactivity have been reported. in this study, the polysaccharide and polyphenol contents, the SOd-like activity and the dpph radical-scavenging activity of water extracts from the root of Actinidia kolomikta produced under different extraction temperatures were investigated. Furthermore, the water extraction-ethanol precipitate (WE-Ep) fraction and the water extraction-ethanol supernatant (WE-ES) fraction were used to test the anti-proliferative action on dld-1 colon cancer cells. Extracts produced using the 100˚C extraction procedure revealed higher extraction yields and antioxidant activities than extracts produced using the 40˚C extraction procedure. the WE-Ep and WE-ES fractions exhibited anti-proliferative effects on the dld-1 cells. moreover, the WE-ES polyphenolenriched fraction possessed more potent anti-proliferative effects on the dld-1 cells by inducing apoptosis compared to the WE-Ep polysaccharide fraction. medicinal plant extracts are generally considered to be relatively non-toxic at low doses and are not thought to cause major side effects compared to those observed with drugs. Wild A. kolomikta may provide an alternative to currently employed cancer therapies, and may be used as a natural health food with antioxidant actions.

Antioxidant Activity Analysis of Native Actinidia arguta Cultivars

“…In comparison, the TPC in the leaves and stems of kiwiberry cultivars was found to be 4-and 2-fold higher, respectively, than those in widely recognized medicinal plants and functional foods, such as Angelica gigas, Morus alba, and red ginseng [36]. However, the methanol extract of Actinidia kolkmikta roots demonstrated a TPC of 201.9 mg GAE•g −1 , which is 20-fold higher than that observed in A. arguta in our study, suggesting that different extraction methods potentially influence the concentrations detected [37]. Our study was the first to compare the TPC and TFC in vegetative tissues of different kiwiberry cultivars and found that they all contain high levels of TPC and TFC, suggesting significant potential for their use in functional and medicinal products.…”

Inhibitory Effects of Chemical Constituents from Actinidia kolomikta on LPS-Induced Inflammatory Responses

“…studies verified that the plant produces a variety of glycosides, flavonoids, polyphenols, sterols, triterpenoids, organic acids, and vitamin C (Chesoniene et al 2004;Zuo et al 2012). Recent pharmacological studies have reported that an extract of A. kolomikta possessed several biological properties, including antioxidant, anti-tumor, anti-proliferative, anti-allergy, and anti-hyperglycemic activities (Guan et al 2011;Zuo et al 2012;Hu et al 2015). Although many pharmacological activities have been reported, the components responsible for the anti-inflammatory properties have not yet been identified.…”