Antioxidant and antimicrobial potential of two extracts from Capparis spinosa L. and Rumex nervosus and molecular docking investigation of selected major compounds

AlMousa, Lujain Abdulaziz; AlFaris, Nora A.; Alshammari, Ghedeir M.; AlTamimi, Jozaa Z.; Alsyadi, Muneer M.; Alagal, Reham I.; Yahya, Mohammed Abdo

doi:10.1016/j.sjbs.2022.103346

Cited by 7 publications

(6 citation statements)

References 33 publications

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“…Our results show that the leaves of R. nervosus have a high content of total phenols. In RNL, the total phenolic content in ethanolic extract was 171.15 mg GAE/g [45]. Based on the above findings, RNL can be considered attractive for food and pharmaceutical applications due to its high content of antioxidants.…”

Section: Discussionmentioning

confidence: 80%

In vitro phytochemical analysis and antibacterial and antifungal efficacy assessment of ethanolic and aqueous extracts of Rumex nervosus leaves against selected bacteria and fungi

et al. 2022

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Background and Aim: Scientists are interested in identifying natural antibiotic substitutes that are effective against drug-resistant pathogenic microbes and spoilage fungi to counter pathogens and reduce the major public health problem of antibiotic residues in animal products. This study aimed to evaluate the antimicrobial activity of Rumex nervosus leaves (RNL) as a medicinal herb against four bacterial and two fungal strains using absolute ethanol, 50% ethanol, and aqueous extracts. Materials and Methods: The antimicrobial activities of various RNL extracts against selected microbes were evaluated using the disk diffusion antibiotic susceptibility test, minimum inhibitory concentrations (MICs), minimum bactericidal concentrations (MBCs), minimum fungicidal concentrations, and the poisoned food technique. Results: The absolute ethanol RNL extract showed the best bacteriostatic/bactericidal activity against Salmonella Typhimurium, Escherichia coli, and Staphylococcus aureus (MIC/MBC: 0.20/0.40, 0.20/0.40, and 0.32/0.65 mg/mL, respectively). The diameter of the zone of inhibition was larger (p < 0.05) for the 100% ethanol RNL extract (8.17 mm) against Salmonella Typhimurium, the 50% ethanol-RNL extract (11.5 mm) against E. coli, and the aqueous RNL extract (14.0 mm) against S. aureus than for any other bacterial isolate. The aqueous RNL extract strongly (p < 0.0001) inhibited the mycelial growth of Aspergillus fumigatus (100%) and Aspergillus niger (81.4%) compared with the control. Conclusion: The results of this study suggest that RNL is a promising new natural antimicrobial agent for food preservation. To date, most research on the antimicrobial properties of natural herbs has been conducted in vitro, with few exceptions in vivo and intervention-based research.

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Section: Discussionmentioning

confidence: 80%

In vitro phytochemical analysis and antibacterial and antifungal efficacy assessment of ethanolic and aqueous extracts of Rumex nervosus leaves against selected bacteria and fungi

et al. 2022

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“…This was thoroughly owned to the condensed form of tannin. Further, authenticated the favourable and sustainable link between the tannins and quenching of DPPH free radicals (AlMousa et al, 2022).…”

Section: Discussionmentioning

confidence: 91%

Antioxidant, Antifungal and Cytotoxic Impact of Acacia nilotica Bark Aqueous Extract

Janani¹,

Anbumani²,

Vizhi³

et al. 2022

IJZI

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The medicative plants were copiously applied in the healing of health complications. Traditionally implemented, medicative-worthy Acacia nilotica (Fabaceae family), is applied globe-wide in customary healing practices. Here, we have tried to unravel the antioxidant, fungicidal, antibacterial and cytotoxic trait of A. nilotica bark aqueous extract. Phyto-content testing revealed presence of flavonoids, tannins, alkaloids, phenols, carbohydrates, proteins, and amino acids. The antioxidant efficacies were 39.12 µg/ml (for DPPH assay) and 42.64 µg/ml (for NO assay) as IC50 ranges, respectively. The bark aqueous extract manifested fungicidal impact on all the screened fungal strains with the highest inhibitory zone against A. fumigatus (19.5 ± 0.45 mm). The MTT assay of bark aqueous extract registered a dose-related cytotoxic impression with 39.05 µg/ml (IC50 outcome). Hence, it emphasizes strongly that A. nilotica bark aqueous extract is a prospective therapeutic source and it is indispensable to further scrutinize its therapeutic and curative properties.

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“…Bark and leaves of Kasokal showed less activity on the tested bacterial methanol extract but had moderate activity against B. cereus Frankland & Frankland, B. megaterium de Bary, Sarcina lutea (Schroeter) Cohn, E. coli, S. aureus, S. paratyphi, S. typhi (Schroter) Warren & Scott, S. boydii, S. dysenteriae (Shiga) Castellani & Chalmers, V. mimicus Davis, V. parahemolyticus (Fujino) Sakazaki, Iwanami, & Fukumi, S. cerevacae and C. albicans (Robin) Berkhout [42], conversely Rana et al [43] found strong activity against S. aureus and S. typhi with very low cytotoxicity. Kasene bark and fruit showed strong activity against S. aureus, Enterococcus faecalis (Andrewes & Horder) Schleifer & Kilpper-Bolz, E. coli, Proteus vulgaris Hauser and C. albicans and molecular modeling showed that almitic acid, pyrogalol and isopropylisothiocyanate are antimicrobial compounds [44] and demonstrated genotoxin potential against E. coli [45]. The antimicrobial activity of these plants needs to be analyzed when combined and rarely hot extracted as in the production of Minyak Sumbawa.…”

Section: Fatty Acid Compositionmentioning

confidence: 99%

Antimicrobial Activity and Cytoxicity of Several Sumbawa Traditional Oils (Minyak Sumbawa) in Sumbawa Regency, West Nusa Tenggara, Indonesia

Rimbun Anggih Chaidir,

Manguntungi,

Zaenal Mustopa

et al. 2023

E3S Web Conf.

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Sumbawa oil or Minyak Sumbawa, is one of Indonesia’s original traditional oils used for more than just external applications and is believed to treat various diseases, from body aches and stomach infections to post-surgery treatment. However, there still needs to be more research that scientifically discusses its medicinal effects. This study evaluates the antimicrobial properties and cytotoxicity of several locally made Minyak Sumbawa in Sumbawa Regency, West Nusa Tenggara, Indonesia. Minyak Sumbawa from Batu Lanteh (BTL) showed the highest antimicrobial properties against Salmonella thypi, Listeria monocytogenes, Escherichia coli, Staphylococcus aureus compared to those from Lunyuk (LNK), Pernek (PRN), Taliwang (TLW), Utan (UTN) and from Sumbawa Besar (SBW). In contrast, Minyak Sumbawa from Labuan Badas (BDS) has the highest activity against Staphylococcus epidermidis. Using the BSLT method, all samples showed low toxicity. The result showed that Minyak Sumbawa has various activities against gram-positive and negative bacteria and is safe for consumption overall. Since the oils were made with different recipes, therefore it will affect its chemical constituent. On the other hand, Minyak Sumbawa can be modified accordingly for specific health benefits by adjusting and standardizing the recipe to improve the quality of Indonesian traditional medicine.

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Antioxidant and antimicrobial potential of two extracts from Capparis spinosa L. and Rumex nervosus and molecular docking investigation of selected major compounds

Cited by 7 publications

References 33 publications

In vitro phytochemical analysis and antibacterial and antifungal efficacy assessment of ethanolic and aqueous extracts of Rumex nervosus leaves against selected bacteria and fungi

In vitro phytochemical analysis and antibacterial and antifungal efficacy assessment of ethanolic and aqueous extracts of Rumex nervosus leaves against selected bacteria and fungi

Antioxidant, Antifungal and Cytotoxic Impact of Acacia nilotica Bark Aqueous Extract

Antimicrobial Activity and Cytoxicity of Several Sumbawa Traditional Oils (Minyak Sumbawa) in Sumbawa Regency, West Nusa Tenggara, Indonesia

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