Antioxidant and Antimicrobial Effects of the Mangrove Tree<i>Heritiera fomes</i>

Wangensteen, Helle; Dang, Huong Cam Thi; Uddin, Shaikh Jamal; Alamgir, Mahiuddin; Malterud, Karl Egil

doi:10.1177/1934578x0900400311

Cited by 20 publications

(26 citation statements)

References 24 publications

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“…Both groups of compounds possessed high 15-LO inhibitory ability, with compound 3 and 7 being the most active ones. The 15-LO inhibition of 1 , 2 , 3 and 7 is in accordance with previous investigations [23,30]. Substances 4 , 5 and 6 , however, seem to be previously unreported as 15-LO inhibitors.…”

Section: Resultssupporting

confidence: 92%

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Extracts, Anthocyanins and Procyanidins from Aronia melanocarpa as Radical Scavengers and Enzyme Inhibitors

Slimestad²,

et al. 2013

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Extracts, subfractions, isolated anthocyanins and isolated procyanidins B2, B5 and C1 from the berries and bark of Aronia melanocarpa were investigated for their antioxidant and enzyme inhibitory activities. Four different bioassays were used, namely scavenging of the diphenylpicrylhydrazyl (DPPH) radical, inhibition of 15-lipoxygenase (15-LO), inhibition of xanthine oxidase (XO) and inhibition of α-glucosidase. Among the anthocyanins, cyanidin 3-arabinoside possessed the strongest and cyanidin 3-xyloside the weakest radical scavenging and enzyme inhibitory activity. These effects seem to be influenced by the sugar units linked to the anthocyanidin. Subfractions enriched in procyanidins were found to be potent α-glucosidase inhibitors; they possessed high radical scavenging properties, strong inhibitory activity towards 15-LO and moderate inhibitory activity towards XO. Trimeric procyanidin C1 showed higher activity in the biological assays compared to the dimeric procyanidins B2 and B5. This study suggests that different polyphenolic compounds of A. melanocarpa can have beneficial effects in reducing blood glucose levels due to inhibition of α-glucosidase and may have a potential to alleviate oxidative stress.

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Section: Resultssupporting

confidence: 92%

“…Trimeric procyanidin (compound 7 ) showed higher radical scavenging activity than the dimeric procyanidins (compound 5 and 6 ). The radical scavenging ability of compound 5 and 7 is in good accordance with the literature [23,24]. Compound 6 , however, seems to be previously unreported as a DPPH scavenger.…”

Section: Resultssupporting

confidence: 89%

Extracts, Anthocyanins and Procyanidins from Aronia melanocarpa as Radical Scavengers and Enzyme Inhibitors

Slimestad²,

et al. 2013

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“…The gradual increase of LOX activity during the progression of water deficit suggests a strict relationship of this enzyme with drought stress (Sofo et al 2004). Bioactivity studies showed high 15-LOX-inhibiting activities of the bark extracts of the mangrove tree Heritiera fomes, which could be ascribed to its high content of procyanidins as antioxidants (Wangensteen et al 2009). Plant survival under drought stress involves effective inhibition of LOX and scavenging of H 2 O 2 by the antioxidative mechanism.…”

Section: Discussionmentioning

confidence: 97%

Comparative analysis of some biochemical responses of three indica rice varieties during polyethylene glycol-mediated water stress exhibits distinct varietal differences

et al. 2009

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Extensive investigation into plant response and adaptation to diverse osmotic stresses like high salt/dehydration/low temperature, involving a broad spectrum of cellular physiological and biochemical changes, is essential to unravel intrinsic mechanism to mitigate against such stresses. In our previous communications, we conducted biochemical analyses of indica rice varieties, subjected to exogenous salt/abscisic acid-mediated oxidative stress. The aim of this study was to compare differential biochemical responses of the salt-sensitive (IR-29), salt-tolerant (Pokkali) and aromatic (Pusa Basmati or PB) rice varieties during polyethylene glycol (PEG)-induced dehydration stress. The greater susceptibility of IR-29 and PB, to water scarcity, was reflected by the higher toxic Na ? and putrescine accumulation, considerable decrease in (reduced/oxidized) glutathione, maximal increment in protease activity and greater downregulation of nitrate reductase activity. On the other hand, Pokkali appeared to suffer lesser damages as evidenced from much lower endogenous Na ? but higher K ? , Ca 2? and Mg 2? accumulation, registering the highest levels of osmolytes like glycinebetaine and higher polyamines (spermidine and spermine) accounting to improved relative water content, higher (reduced/oxidized) glutathione, maximal induction of the enzyme phenylalanine ammonia-lyase and practically unhindered nitrate reductase activity, following PEG treatment. The highest induction of sugars and proline in IR-29 and PB probably played the osmoprotective/antioxidative functions, enabling to a certain extent to heighten their lipoxygenase inhibition or H 2 O 2 scavenging potential, more than Pokkali, to ward off oxidative damages and sustain survival under critical dehydrated situations. Thus, the salt-tolerant Pokkali also showed prominent dehydration-tolerance properties, whereas the aromatic rice PB, almost identical in their biochemical responses to IR-29, showed greater sensitivity to PEG-mediated water deficit.

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“…Because tolerance to biotic stress has been correlated with endophytic fungal natural products, it is likely that H . fomes would be a rich source of endophytic fungi, which produce chemically diverse and biologically active secondary metabolites enhancing the host allelopathic effects, and providing protection against phytopathogenic microbes (Patra & Thatoi, ; Wangensteen, Dang, Uddin, Alamgir, & Malterud, ).…”

Section: Introductionmentioning

confidence: 99%

Anti‐MRSA activity of oxysporone and xylitol from the endophytic fungus Pestalotia sp. growing on the Sundarbans mangrove plant Heritiera fomes

Nurunnabi

Nahar

Al-Majmaie

et al. 2017

Phytotherapy Research

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Heritiera fomes Buch.-Ham., a mangrove plant from the Sundarbans, has adapted to a unique habitat, muddy saline water, anaerobic soil, brackish tidal activities, and high microbial competition. Endophytic fungal association protects this plant from adverse environmental conditions. This plant is used in Bangladeshi folk medicine, but it has not been extensively studied phytochemically, and there is hardly any report on investigation on endophytic fungi growing on this plant. In this study, endophytic fungi were isolated from the surface sterilized cladodes and leaves of H. fomes. The antimicrobial activities were evaluated against two Gram-positive and two Gram-negative bacteria and the fungal strain, Candida albicans. Extracts of Pestalotia sp. showed activities against all test bacterial strains, except that the ethyl acetate extract was inactive against Escherichia coli. The structures of the purified compounds, oxysporone and xylitol, were elucidated by spectroscopic means. The anti-MRSA potential of the isolated compounds were determined against various MRSA strains, that is, ATCC 25923, SA-1199B, RN4220, XU212, EMRSA-15, and EMRSA-16, with minimum inhibitory concentration values ranging from 32 to 128 μg/ml. This paper, for the first time, reports on the anti-MRSA property of oxysporone and xylitol, isolation of the endophyte Pestalotia sp. from H. fomes, and isolation of xylitol from a Pestalotia sp.

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Antioxidant and Antimicrobial Effects of the Mangrove TreeHeritiera fomes

Cited by 20 publications

References 24 publications

Extracts, Anthocyanins and Procyanidins from Aronia melanocarpa as Radical Scavengers and Enzyme Inhibitors

Extracts, Anthocyanins and Procyanidins from Aronia melanocarpa as Radical Scavengers and Enzyme Inhibitors

Comparative analysis of some biochemical responses of three indica rice varieties during polyethylene glycol-mediated water stress exhibits distinct varietal differences

Anti‐MRSA activity of oxysporone and xylitol from the endophytic fungus Pestalotia sp. growing on the Sundarbans mangrove plant Heritiera fomes

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