Antioxidant and Antimicrobial Activities ofPogostemon cablin(Blanco) Benth.

Abstract

Pogostemon cablin (Lamiaceae) has been widely used in traditional medicine. In this study, the antioxidant and antimicrobial activities of leaves from P. cablin extracts were investigated. The water extracts had the highest total phenolic content 116.88±0.48 mg gallic acid equivalent/g of dry plant extract. Nevertheless, high levels of total flavonoid content were found in ethanolic extracts 280.12 ± 2.04 mg quercetin equivalent/g of dry plant extract. The highest antioxidant activities were found for the ethanolic extract (IC 50 = 18 ± 0.90, 20 ± 0.24 g/mL) by DPPH and ABTS scavenging assays, respectively. Both extracts showed moderate inhibition of superoxide inhibition (O 2•− ) and nitric oxide (NO) production in concentration-dependent manner. Antibacterial activity was calculated by disk diffusion, minimum inhibitory concentration (MIC), and minimum bacterial concentration (MBC). The ethanolic extract had the greatest activity against methicillin resistant Staphylococcus aureus, methicillin sensitive S. aureus, and Streptococcus pyogenes with zone diameters of 11.67 ± 1.53, 10.33 ± 2.52, and 10.33 ± 1.15 mm, respectively. The corresponding MIC and MBCs were 5, 0.625, and 0.039 mg/mL. P. cablin extracts contain antioxidant and antibacterial properties that should be exploited for possible clinical application.

In VitroandIn VivoAntimalarial Activities and Toxicological Assessment ofPogostemon Cablin(Blanco) Benth

“…This result was consistent with that of a previous study, which reported that the ethanolic P. cablin extract exhibited a noncytotoxic effect, with more than 70% cell viability. 39 The selection of the extract with the best antimalarial activity in an animal model that is widely used to predict drug activity was based on the greatest antimalarial activity and the lowest toxicity. According to the results of in vitro studies, the ethanolic P. cablin extract exhibited better antimalarial activity against the P. falciparum K1 strain and had no toxicity toward Vero cells.…”

Patchouli Essential Oil and Its Derived Compounds Revealed Prebiotic-Like Effects in C57BL/6J Mice

“…Patchouli is a traditional Chinese medicine for the treatment of gastrointestinal symptoms. PEO and its derived compounds PA, PO, and β-PAE are the main active ingredients of patchouli that possess anti-inflammation, anti-oxidant, anti-microbial, anti-allergy, and anti-cancer effects based on the cellular and animal studies (Li et al, 2011; He et al, 2013; Jeong et al, 2013; Dechayont et al, 2017). It is our interest to investigate whether the commensal GM plays a role in the health benefits of patchouli.…”

“…These components of PC exhibited common as well as unique pharmaceutical activities (Li et al, 2014; Zhang et al, 2016a; Zhang et al, 2016b). For example, reports showed that PEO, PA, PO, and β-PAE possessed anti-inflammation, anti-oxidant, anti-cancer, immunomodulation in cellular and animal studies (Li et al, 2011; Liao et al, 2013; Jeong et al, 2013; Dechayont et al, 2017). Studies also showed that PEO, PA, and PO can suppress the growth of methicillin-resistant Staphylococcus aureus , Escherichia coli , and Helicobacterium both in vitro and in vivo experiments (Peng et al, 2014; Xie et al, 2016).…”

In Vitro Antioxidant Activity of Phyllodium Pulchellum L. Desv - An Threatened Medicinal Plant

“…Along with the good number widely used procedures for measurement of antioxidant activity capacity, the DPPH radical scavenging analysis is one of the top known, correct, and regularly employed to measure the electron donating ability of the plant [12,13]. Dechayont et al, reported that the moderate antioxidant activity from Pogostemon cablin and inhibited bacteria commonly responsible for community and hospital acquired infections [14]. Usmangani et al reported that leaf and fruit extracts of D. palmatus were determined to have a certain level of radical scavenging effect, proportional to their level of phytochemicals [15].…”