Antioxidant and Antihypertensive Activities of Styela plicata according to Harvesting Time and Size

Park, Ji Won; You, Dong-Hyun; Bae, Myung-Suk; Kim, Jung-Mi; Lee, Jong-Hwa; Kim, Suk-Ju; Jeon, Y; Park, Eunju; Lee, Seung‐Cheol

doi:10.3746/jkfn.2011.40.3.350

Cited by 4 publications

(1 citation statement)

References 20 publications

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“…Compared to the previous reports, free radical scavenging activity of enzymatic hydrolysates were more effective than that of organic solvent and aqueous extracts from S. plicata. 11,18 The enzymatic hydrolysis is one of the primary approaches for the effective release of bioactive peptides from food, 8 and is widely used to improve and upgrade the functional and nutritional properties of proteins. 19 Therefore, tryptic hydrolysate was selected for further study.…”

Section: Preparation Of S Plicata Hydrolysates and Their Antioxidant ...mentioning

confidence: 99%

A hexameric peptide purified from Styela plicata protects against free radical-induced oxidative stress in cells and zebrafish model

Kim

Jung

et al. 2016

RSC Adv.

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Section: Preparation Of S Plicata Hydrolysates and Their Antioxidant ...mentioning

confidence: 99%

A hexameric peptide purified from Styela plicata protects against free radical-induced oxidative stress in cells and zebrafish model

Kim

Jung

et al. 2016

RSC Adv.

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Reproductive Cycle of Styela plicata(Urochordata: Ascidiacea) in Yeosu Coastal Waters

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2023

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Protective effects of the antioxidant extract collected from Styela clava tunics on UV radiation-induced skin aging in hairless mice

Koh

Kim

et al. 2016

International Journal of Molecular Medicine

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Ultraviolet (UV) radiation is considered a primary cause of skin damage, which is characterized by deep wrinkles, roughness, laxity and pigmentation through oxidative stress and oxidative photodamage. To examine the therapeutic effects of ethanol extract of Styela clava tunics (EtSCT) on UV radiation-induced skin aging in hairless mice, alterations in skin phenotype, histological structures, inflammation, endoplasmic reticulum (ER) stress, oxidative conditions and toxicity were investigated during 13 weeks of UV irradiation and topical application of EtSCT. EtSCT showed high reducing power (3.1%), 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity (92.7%) and NO scavenging activity (15.6%) due to its high total flavonoids (15.3 mg/ml) and total phenolics (36.8 mg/ml). The topical application of EtSCT suppressed photoaging of the skin of UV-irradiated mice, and this was demonstrated by the inhibition of wrinkle formation, the suppression of the erythema index as well as the prevention of transepidermal water loss. Additionally, the epidermal thickness and adipocytes number were recovered to a similar level as that in the no radiation group in the UV + EtSCT‑treated groups compared with the UV + vehicle‑treated group, and the expression of collagen I increased. The attenuation of mitogen‑activated protein kinase and ER stress signaling pathways activated by reactive oxygen species was also detected in the UV + EtSCT‑treated group. Inflammatory responses including the infiltration of mast cells, CD31 expression and interleukin-6 secretion were significantly lower in the UV + EtSCT-treated groups. Moreover, the concentration of malondialdehyde was reduced and the activity of superoxide dismutase was effectively recovered in the UV + EtSCT-treated groups compared with that in the vehicle-treated groups. Liver and kidney toxicity factors were maintained at a constant level. These results suggest that EtSCT has the potential for use as therapeutic drug which protects against skin aging by regulating the skin morphology, histopathological structures, ER stress, inflammation and oxidative conditions.

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Antioxidant and Antihypertensive Activities of Styela plicata according to Harvesting Time and Size

Cited by 4 publications

References 20 publications

A hexameric peptide purified from Styela plicata protects against free radical-induced oxidative stress in cells and zebrafish model

A hexameric peptide purified from Styela plicata protects against free radical-induced oxidative stress in cells and zebrafish model

Reproductive Cycle of Styela plicata(Urochordata: Ascidiacea) in Yeosu Coastal Waters

Protective effects of the antioxidant extract collected from Styela clava tunics on UV radiation-induced skin aging in hairless mice

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