Antioxidant and Antihyperlipidemic Properties of Different Granulometric Classes of Adansonia digitata Pulp Powder

Hypolipidemic effects of microencapsulated powder fraction from Hibiscus sabdariffa. L calyx in hyperlipidic rats

“…As illustrated in Figure 1 (A), the levels of MDA in liver and kidney homogenates and in blood plasma of rats subjected to HLD were significantly elevated compared to rats subjected to the normal diet. This elevation of MDA has been reported to be related to the high intake of polyunsaturated fatty acids (potential targets of free radicals) contained in the diet of these rats [22]. Indeed, singlet oxygen ( 1 O2) binds directly to the double bonds of the fatty acid to give free radicals such as hydroperoxides [12].…”

“…Indeed, the similar action of NMEPHS to atorvastatin could be due to the high content of bioactive components, especially phenolic compounds (flavonoid polyphenols, tannins and anthocyanins) present in the powder fraction of H. sabdariffa calyx causing the oxidation of fat cells responsible for the increase of the body fat mass. Ngatchic et al (2020) [22], also demonstrated that administration of Adansonia digitata pulp powder of particle size class <50 µm to rats fed with a diet high in saturated fatty acids and cholesterol resulted in a significant decrease in weight gain and adiposomatic index. Moreover, the bioactive compounds present in H. sabdariffa calyx powder can enhance its ability to reduce fat, liver, as well as body weight gain, however, these bioactive compounds are susceptible to degradation during processing, ingestion, and/or storage by factors such as temperature, oxygen, and light, as well as by conditions in the gastrointestinal tract (pH, presence of enzymes, and interactions with other nutrients) [24,25].…”

“…The atorvastatin, the non and encapsulated HSCP were dissolved into distilled water at a volume of 10 mL/kg body weight and administered to the animals by gavage at the dosage of 10 mg/kg (for atorvastatin) and 250 mg/kg (non and microencapsulated HSCP) following the methodology reported by Deli et al (2020) [14] and Ngatchic et al (2020) [22]. The volume of the HSCP solution or atorvastatin solution administrated to the rats was determined based on the weight of the animals using the equation 1.…”

“…The total cholesterol, the triglycerides (TG), the HDL-cholesterol were assayed using a colorimetric enzymatic method as described by Ngatchic et al (2020) [22]. The low-density lipoprotein cholesterol (LDL-C), very low-density lipoprotein cholesterol (VLDL-C), and the atherogenic index (AI) were determined following the equations 4, 5 and 6, respectively.…”

“…Several studies [5,22,23], have reported that a high diet saturated in fatty acids and cholesterol induce hyperlipidemia which is associated in an increment of abdominal fat. In our experimental conditions, a hyperlipidic diet (HLD) led to abnormal weight gain in rats, which is well illustrated in table 2.…”