Antioxidant and antihyperlipidemic effects of Ajwa date (<i>Phoenix dactylifera</i>L.) extracts in rats fed a cholesterol‐rich diet

Alqarni, Mohamed M. M.; Osman, Magdi A.; Al‐Tamimi, Dalia S.; Gassem, Mustafa A.; Al‐Khalifa, Abdulrahman S.; Juhaimi, Fahad Al; Ahmed, Isam A. Mohamed

doi:10.1111/jfbc.12933

Cited by 27 publications

(35 citation statements)

References 31 publications

(65 reference statements)

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“…Besides, date seeds are used as animal feed or caffeine-free coffee replacements in some areas. The Ajwa date seed oil includes sterol, phytochemistry, oleic, palmitic and fatty acids and their derivatives; these have antibacterial, antioxidant, anticancer and antilipidemic effects [72,73]. The present work reported that Ajwa date seed oil (AWSO) contains hexadecanamide, 5-hydroxymethylfurfura, 9-octadecenamide, (Z)-, oleic acid, cis-11-eicosenamide, dodecanoic acid and palmitic acid.…”

Section: Discussionmentioning

confidence: 88%

Screening Pilot Study of Fruit Seed Compositions by GC-MS and Their Potential Scenario Anti ACE2 and 2rh1 Receptors as a Recycling Possibility in the Coronavirus Pandemic

Hamouda¹,

Farawilla²,

Attafi³

et al. 2021

JCMR

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Background: Since 2019, several critical effects of the coronavirus pandemic have surfaced, including its psychological problems such as depression. The World Health Organization has approved a group of drugs and vaccines. However, the world still faces novel coronavirus mutations, requiring more ideas to investigate a drug, vaccine and phytochemical potential chemoprevention proposal. Severe Acute Respiratory Syndrome-Coronavirus (SARS-CoV)-2 co-operates directly with the Angiotensin-Converting Enzyme 2 (ACE2) to penetrate the target cells.Aims: We aim to introduce the possibility of studying seed oil extract as an anti-depression, anti-stress, anti-epinephrine receptor (PDB: 2rh1) and as potentially binding anti-angiotensinconverting enzyme 2 (ACE2) agent.

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Section: Discussionmentioning

confidence: 88%

Screening Pilot Study of Fruit Seed Compositions by GC-MS and Their Potential Scenario Anti ACE2 and 2rh1 Receptors as a Recycling Possibility in the Coronavirus Pandemic

Hamouda¹,

Farawilla²,

Attafi³

et al. 2021

JCMR

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“…Ghiaba et al [29] studied five varieties of Algerian date palm fruit by cyclic voltammetric technique and reported that IC 50 against the superoxide anion radical was ranged from 33.17 -85.23 mg/L. Another study conducted by Algarni et al [11] reported that oral administration of Ajwa date extract showed significant increase of superoxide dismutase (SOD) enzyme in hypercholesterolemic rats, however, the increase of SOD activity is in agreement with our finding that DPL extracts possess a good scavenging activity against superoxide anion.…”

Section: Dpl Scavenging Activity Against Superoxide Anion Radicalmentioning

confidence: 99%

“…Ajwa date polyphenol extract is reported to be a good source of phytochemical and micronutrients, thereafter, administration of Ajwa date polyphenol extract to hypercholesterolemic rats improved serum lipid profile and the antioxidant status in liver and plasma tissues [11]. Saryono et al [12] reported that the levels of total cholesterol and LDL were significantly decreased in rats induced with high cholesterol diet, after their diet has been supplemented with PDS extract.…”

Section: Introductionmentioning

confidence: 99%

Towards the Utilization of Date Palm (<i>Phoenix dactylifera</i>) Leaves as a Rich Source of Antioxidants

Abuelgassim¹

2020

JFNR

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Three varieties of date palm (Phoenix dactylifera) leaves (DPL) namely: Sagaie, Khalas, and Nabtat Alsaif were examined for their antioxidant activities. DPL extracts showed a total phenolic content ranged between 1498.14 ± 100.52-4374.76 ± 657.64 mg gallic acid equivalent (GAE)/100g dry weight (DW) and a total flavonoid ranged between 134.70 ± 16.24-224.62 ± 22.35 mg quercetin (QE)/100g (DW). The IC 50s for scavenging ABTS radical were ranged between 71.87 ± 14.37-217.87 ± 27.40µg Trolox equivalent, whereas that required for scavenging DPPH were ranged between 197.86 ± 17.60-693.32 ± 25.44 µg ascorbic acid equivalent. DPL extracts potentially scavenged hydroxyl and superoxide anion radicals, IC 50s values were ranged between 208.04 ± 12.76-719.63 ± 24.38 and 825.92 ± 19.40-1193.20 ± 28.74µg GAE respectively. DPL extracts showed a good activity against ferric reducing antioxidant power (FRAP) ranged between 7.69 ± 0.47-22.13 ± 1.36 mmol ascorbic acid equivalent/100g. DPL extracts showed a considerable antioxidant activity, therefore, DPL could be effectively used as natural source of antioxidant in food and pharmaceutical industries.

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“…I 2 for heterogeneity=79%, P <0.00001 and postprandial plasma glucose (PPPG), odd ratio -28.19, 95% CI= -60.66-4.29, P =<0.0001. I 2 for heterogeneity=92%, P =0.09) was observed. While the effect on HbA1 c was neutral, odd ratio, -.20, 95% CI=-.46 -.06, P=0.13.…”

mentioning

confidence: 99%

“…While the effect on HbA1 c was neutral, odd ratio, -.20, 95% CI=-.46 -.06, P=0.13. I 2 for heterogeneity=0. %, P=0.55.…”

mentioning

confidence: 99%

Dates fruits effects on blood glucose among patients with diabetes mellitus: A review and meta-analysis

Mirghani

2021

Pak J Med Sci

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Background & Objective: Dates fruit is known for its great nutritional value and two to three servings of dates fruit/day are beneficial for patients with diabetes. However, some may advice against this cheap and widely available fruit consumption. Besides, 12% of the population Worldwide are either suffering or are at risk of developing diabetes, but no previous meta-analysis has assessed this important issue. Thus, the study aimed to investigate the effects of date’s fruit on glycemia among patients with diabetes. Methods: A systematic literature search was conducted in PubMed, Medline, EBSCO, Cochrane, and Google Scholar databases for trials published in English from the first published article up to December 2020. The following keywords were used: “dates fruit and glycemic control”, “dates fruit and blood glucose”, “dates fruit and HbA1c” without limitations regarding the date of publication. Results: Out of the 942 references identified, only 10 cohorts from five full texts were included, a reduction of Fasting plasma glucose (FPG), odd ratio, -24.79, 95% CI=-34.75, -14.83 P =0.002. I2 for heterogeneity=79%, P <0.00001 and postprandial plasma glucose (PPPG), odd ratio -28.19, 95% CI=-60.66-4.29, P =<0.0001. I2 for heterogeneity=92%, P=0.09) was observed. While the effect on HbA1c was neutral, odd ratio, -.20, 95% CI=-.46 -.06, P=0.13. I2 for heterogeneity=0. %, P=0.55. Conclusion: Dates fruit was beneficial regarding glycemic control among patients with diabetes, physician may not need to restrict its use among patients with diabetes. The small number of the included studies and the heterogeneity observed in PPPG and FPG sub-analysis limited the current results. Further trials assessing the glycemic indices of various types of dates fruit are needed. doi: https://doi.org/10.12669/pjms.37.4.4112 How to cite this:Mirghani HO. Dates fruits effects on blood glucose among patients with diabetes mellitus: A review and meta-analysis. Pak J Med Sci. 2021;37(4):---------. doi: https://doi.org/10.12669/pjms.37.4.4112 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Antioxidant and antihyperlipidemic effects of Ajwa date (Phoenix dactyliferaL.) extracts in rats fed a cholesterol‐rich diet

Cited by 27 publications

References 31 publications

Screening Pilot Study of Fruit Seed Compositions by GC-MS and Their Potential Scenario Anti ACE2 and 2rh1 Receptors as a Recycling Possibility in the Coronavirus Pandemic

Screening Pilot Study of Fruit Seed Compositions by GC-MS and Their Potential Scenario Anti ACE2 and 2rh1 Receptors as a Recycling Possibility in the Coronavirus Pandemic

Towards the Utilization of Date Palm (<i>Phoenix dactylifera</i>) Leaves as a Rich Source of Antioxidants

Dates fruits effects on blood glucose among patients with diabetes mellitus: A review and meta-analysis

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