Antioxidant and Antifatigue Activities of  Polygonatum Alte-lobatum Hayata Rhizomes in Rats

Horng, Chi‐Ting; Huang, Jian‐Pei; Wang, Huiyun; Huang, Chi‐Chang; Chen, Fu‐An

doi:10.3390/nu6115327

Cited by 52 publications

(46 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Additionally, excessive quantities of MDA lead to free radical generation and lipid peroxidation, which may dysregulate cell function and induce fatigue (9). Antioxidant enzymes, including GSH-Px and SOD, serve important roles in preventing excessive exercise-induced oxidative injury in animals (10). Following 30 min swimming exercise, female mice treated with TM exhibited reduced serum MDA levels compared with the control.…”

Section: The Antioxidant Effects Of Tm In Mice Following 30 Min Exercmentioning

confidence: 99%

“…In the present study, TM treated female and male mice exhibited increased serum, hepatic and muscular SOD and GSH-Px, and decreased MDA and ROS levels to different degrees depending on the concentration of TM administered. Antrodia cinnamomea and Polygonatum alte-lobatum hayata reduce MDA levels and increase the activity of antioxidant enzymes including SOD and GSH-Px, thus protecting cellular structures by combating lipid peroxidation and fatigue (10,15). The antioxidant properties of TM may therefore be responsible for its anti-fatigue effects.…”

Section: Tm (G/kg) Tm (G/kg) ----------------------------------------mentioning

confidence: 99%

“…However, an imbalance between levels of reactive oxygen species (ROS) and antioxidants may induce oxidative stress (7), leading to lipid peroxidation (8). Malondialdehyde (MDA), superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) levels reflect antioxidant capacity (9,10). It has been demonstrated that reversing the depletion of energy resources and inhibiting the generation of free radicals induces positive effects on anti-fatigue and physical abilities, respectively (11).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The anti‑fatigue activities of Tuber melanosporum in a mouse model

Jiang

Chu

et al. 2018

Exp Ther Med

View full text Add to dashboard Cite

Abstract. Tuber melanosporum (TM) is an edible fungus that exhibits antioxidant and anti-tumor activity via its unique bioactive metabolites. The present study analyzed the anti-fatigue effects of TM using a BALB/c mouse model. The anti-fatigue properties of TM were evaluated by assessing the endurance of mice by performing forced swimming, rotary rod and running tests. Following 2 weeks TM treatment, hepatic and muscular ATP, and glycogen levels were increased in mice subjected to 30 min swimming, compared with controls. Similarly, levels of serum lactic acid and lactic dehydrogenase were decreased in the same group, compared with the control. Additionally, TM treatment reduced reactive oxygen species and malondialdehyde levels, and increased superoxide dismutase and glutathione peroxidase levels in the muscle, liver and/or serum. The effect of TM on hormone levels was also investigated in the present study, as different efficacies of TM were observed in male and female mice. TM treatment increased serum levels of progesterone, estradiol and testosterone in female and male mice, whereas a decrease in serum luteinizing hormone levels was only observed in females. A decrease in serum follicle-stimulating hormone levels was identified in females, whereas an increase was observed in males. The current study demonstrated that the anti-fatigue effects of TM occur via the regulation of oxidative stress, energy metabolism and hormone levels.

show abstract

Section: The Antioxidant Effects Of Tm In Mice Following 30 Min Exercmentioning

confidence: 99%

Section: Tm (G/kg) Tm (G/kg) ----------------------------------------mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The anti‑fatigue activities of Tuber melanosporum in a mouse model

Jiang

Chu

et al. 2018

Exp Ther Med

View full text Add to dashboard Cite

show abstract

“…Fatigue, a complex symptom, is accompanied by difficulty in initiating or sustaining activities, resulting from severe stress, mental work, and/or hard physical labour [1]. Liver serves as a reservoir for blood, glycogen, fats, carbohydrates, and even proteins, where protein synthesis and substance metabolism are performed.…”

Section: Introductionmentioning

confidence: 99%

Antifatigue Effects of Antrodia cinnamomea Cultured Mycelium via Modulation of Oxidative Stress Signaling in a Mouse Model

Liu

et al. 2017

BioMed Research International

View full text Add to dashboard Cite

Antrodia cinnamomea, a folk medicinal mushroom, has numerous biological effects. In this study, we aim to assess whether the antifatigue effects of A. cinnamomea mycelia (AC) and its underlying mechanisms are related to oxidative stress signaling using behavioral mouse models and biochemical indices detection. Mice were orally treated with AC at doses of 0.1, 0.3, and 0.9 g/kg for three weeks. AC had no effect on the spontaneous activities of mice indicating its safety on central nervous system. Furthermore, results obtained from weight-loaded forced swimming test, rotary rod test, and exhausted running test confirmed that AC significantly enhanced exercise tolerance of mice. Biochemical indices levels showed that these effects were closely correlated with inhibiting the depletion of glycogen and adenosine triphosphate stores, regulating oxidative stress-related parameters (superoxide dismutase, glutathione peroxidase, reactive oxygen species, and malondialdehyde) in serum, skeletal muscle, and liver of mice. Moreover, the effects of AC may be related with its regulation on the activations of AMP-activated protein kinase, protein kinase B, and mammalian target of rapamycin in liver and skeletal muscle of mice. Altogether, our data suggest that the antifatigue properties of AC may be one such modulation mechanism via oxidative stress-related signaling in mice.

show abstract

“…Delayed occurrence of fatigue and quick recovery are current foci of medical chemistry studies. Clinical drugs used to relieve fatigue are limited, and potential alternatives from natural substances are worth investigating (Horng et al, 2014). Recently, it has been reported that some heparinized tubes for BLA, SUN and SCK analysis.…”

Section: Introductionmentioning

confidence: 99%