Antioxidant and anticoagulant activities of mycelia polysaccharides from Catathelasma ventricosum after sulfated modification

Liu, Yuntao; Tang, Qianqian; Duan, Xiaoyu; Tang, Tingting; Yu, Ke; Zhang, Lan; Cheng, Li; Liu, Aiping; Zhao, Shunsheng; Hu, Bin

doi:10.1016/j.indcrop.2017.10.064

Cited by 65 publications

(28 citation statements)

References 40 publications

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“…This result is consistent with the relation of triple helical structure and anticoagulant activity for sulfated Catathelasma ventricosum polysaccharide as reported by Liu et al. (2018). Perhaps this was due to the difference of the sequence of their sulfated saccharide residues.…”

Section: Resultssupporting

confidence: 93%

“…The negative and positive controls were physiological saline and sodium heparin, respectively. The anticoagulant ability of the polysaccharides was determined as previously described using APTT, PT, and TT as indicators (Liu et al., 2018). All assays were performed in triplicate to calculate the mean value; the anticoagulant activity was expressed as the clotting time.…”

Section: Methodsmentioning

confidence: 99%

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Sulfation, structural analysis, and anticoagulant bioactivity of ginger polysaccharides

Wang

Tang

et al. 2020

Journal of Food Science

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In this study, ginger polysaccharide (GP), ginger polysaccharide 1 (GP1), and ginger polysaccharide 2 (GP2) from ginger were firstly modified by sulfation. Fourier transform infrared, and nuclear magnetic resonance spectra investigation of sulfated ginger polysaccharide (SGP), sulfated ginger polysaccharide 1 (SGP1), and sulfated ginger polysaccharide 2 (SGP2) revealed that the sulfation successfully occurred with the characteristic absorption peak of polysaccharide. Congo red experiment showed that triple helical structure existed in SGP and SGP1, but random coils existed in SGP2. SGP, SGP1, and SGP2 all showed a rough and rugged surface with plenty of small pores. The blood clotting time of SGP2 or SGP at 2 mg/mL in activated partial thromboplastin time (APTT) assay was 41.42 or 38.01 s, respectively, which were approximately 1.33‐ and 1.22‐fold longer than that of the physiological saline. Compared to the saline control group, prothrombin time (PT) was increased by 1.22‐fold with the addition of GP at 2 mg/mL. However, no clotting inhibition phenomenon was observed in thrombin time test even at the concentrations that APTT and PT were obviously prolonged. It indicated that GP2, SGP2, and SGP inhibited the intrinsic pathway of coagulation, but GP inhibited both the intrinsic and extrinsic pathways of coagulation. Hence, ginger polysaccharides might be used as anticoagulants and therapeutic reagents for thrombosis.

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Section: Resultssupporting

confidence: 93%

Section: Methodsmentioning

confidence: 99%

Sulfation, structural analysis, and anticoagulant bioactivity of ginger polysaccharides

Wang

Tang

et al. 2020

Journal of Food Science

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“…Of note, Xiao et al [152] studied the effect of sulfated modification of polysaccharides SPP from Sargassum pallidum on their antioxidant activities, and found that the DPPH scavenging capacity of the modified polysaccharide S-SPP1-4 (sulphate 10.96%) was higher than unmodified SPP (sulphate 3.31%), however, an even higher sulfated modification of polysaccharide S-SPP1-8 (sulphate 13.46%) has lower DPPH scavenging capacity than that of S-SPP1-4. Liu et al [153] also reported a consistent phenomenon. This may be because the further increase of the degree of sulfation breaks the triple-helical structure of the polysaccharide, thus affecting the ability of the polysaccharide to supply hydrogen for the antioxidant activity [153,154].…”

Section: Sulfation Degree and Positionmentioning

confidence: 61%

“…Liu et al [153] also reported a consistent phenomenon. This may be because the further increase of the degree of sulfation breaks the triple-helical structure of the polysaccharide, thus affecting the ability of the polysaccharide to supply hydrogen for the antioxidant activity [153,154]. These findings indicate that polysaccharides with a higher degree of sulfation have greater antioxidant activity with the precondition that the triple-helical structures of polysaccharides are not destroyed.…”

Section: Sulfation Degree and Positionmentioning

confidence: 61%

The Antioxidant Activity of Polysaccharides Derived from Marine Organisms: An Overview

et al. 2019

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Marine-derived antioxidant polysaccharides have aroused extensive attention because of their potential nutritional and therapeutic benefits. However, the comprehensive comparison of identified marine-derived antioxidant polysaccharides is still inaccessible, which would facilitate the discovery of more efficient antioxidants from marine organisms. Thus, this review summarizes the sources, chemical composition, structural characteristics, and antioxidant capacity of marine antioxidant polysaccharides, as well as their protective in vivo effects mediated by antioxidative stress reported in the last few years (2013–2019), and especially highlights the dominant role of marine algae as antioxidant polysaccharide source. In addition, the relationships between the chemical composition and structural characteristics of marine antioxidant polysaccharides with their antioxidant capacity were also discussed. The antioxidant activity was found to be determined by multiple factors, including molecular weight, monosaccharide composition, sulfate position and its degree.

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“…Many studies have demonstrated that the sulfonation of natural polysaccharides is an important way of obtaining new antioxidants agents and the sulfonate groups take an important role in antioxidant activities [37]. The sulfonation of polysaccharides could not only enhance their water solubility, but also changes the chain conformation, thus resulting in the enhanced bioactivities [38]. According to Wang et al [39], the introduction of chemical groups onto polysaccharide molecules could lead to weaker dissociation energy of hydrogen bonding, increasing therefore, the hydrogen donating ability of the macromolecule.…”

Section: Biological Activities Of Native and Sulfonated Lasiodiplodanmentioning

confidence: 99%

Sulfonation of (1→6)-β-D-Glucan (Lasiodiplodan) and Its Antioxidant and Antimicrobial Potential

Calegari¹,

Santos²,

Teixeira³

et al. 2017

JPP

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Abstract:The objective of this study was to investigate the sulfonation of (1→6)-β-D-glucan (lasiodiplodan) as a potentiating mechanism for biological functionalities. Lasiodiplodan was sulfonated by the chlorosulfonic acid-pyridine method. The modified exopolysaccharide was characterized by FT-IR and 13 C NMR spectroscopy, X-ray diffraction and SEM. Antioxidant activity was assessed by the methods of H 2 O 2 and OH radical removal and reducing power. Antimicrobial potential was evaluated by the broth-microdilution method. Sulfonation resulted in a derivative with DS of 0.24. FT-IR analysis indicated the introduction of sulfonyl groups in the macromolecule structure through specific bands in the regions of 1,240 cm -1 and 810 cm -1 . 13 C NMR analysis suggested that sulfonation occurred at carbon 2 of the glucose residue. Sulfonation led to morphological changes in the structure of the biopolymer resulting in a heterogeneous structure with the presence of fibrils. Derivatization promoted an increase in the antioxidant ability of the macromolecule, with a high OH removal potential (74.32%). Bacteriostatic activity against E. coli (Escherichia coli) and S. enterica (Salmonella enterica) typhimurium and fungicidal activity against C. albicans (Candida albicans) and C. tropicalis (Candida tropicalis) were found in the sulfonated sample. Sulfonation potentiated the antioxidant and antimicrobial activities of the biomacromolecule, suggesting that it is a potentiating mechanism of biological functions.

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Antioxidant and anticoagulant activities of mycelia polysaccharides from Catathelasma ventricosum after sulfated modification

Cited by 65 publications

References 40 publications

Sulfation, structural analysis, and anticoagulant bioactivity of ginger polysaccharides

Sulfation, structural analysis, and anticoagulant bioactivity of ginger polysaccharides

The Antioxidant Activity of Polysaccharides Derived from Marine Organisms: An Overview

Sulfonation of (1→6)-β-D-Glucan (Lasiodiplodan) and Its Antioxidant and Antimicrobial Potential

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