Antioxidant and anticancer activities of chamomile (Matricaria recutita L.)

Abstract

ObjectivesThe present study aimed at determining the antioxidant activity, total phenols and flavonoids and to evaluate the antiproliferative activity of ethanolic extract of Matricaria recutita L. (chamomile). The antioxidant activities were measured using the 2, 2-diphenyl-1-picrylhydrazyl (DPPH) assay. The total phenolic content was measured by the Folin–Ciocalteu assay. The flavonoid content was determined using the aluminum chloride method. The MTT assay was used to estimate the antiproliferative activities against human hepatoma (HepG2) cancer cell line. We assessed the mode of action of the extract as a cancer preventive agent and reported its ability to regulate tumor angiogenesis by down regulating in a dose dependent manner the expression of some proteins involved in the process.ResultsThe percentage inhibition of DPPH scavenging activity was dose-dependent ranging between (94.8% ± 0.03) at 1.50 mg/mL and (84.2% ± 0.86) at 0.15 mg/mL. It showed high polyphenols (21.4 ± 0.327 mg GAE/g) and high flavonoids content (157.9 ± 2.22 mg QE/g). Effect of extract was investigated against HepG2 cells. A dose-dependent reduction in cell viability was recorded in cells treated with the extract. The IC50 was ~ 300 µg/mL. It significantly inhibited the level of important prerequisite angiogenesis markers both in HepG2 cells and ex vivo.Electronic supplementary materialThe online version of this article (10.1186/s13104-018-3960-y) contains supplementary material, which is available to authorized users.

Tratamento alternativo da síndrome de tensão pré-menstrual com camomila, maçã e maracujá

“…Estas observações de melhora dos sintomas citados anteriormente são descritas por meio de estudos clínicos realizados com a camomila na forma de chá em períodos prolongados, onde são descritas suas ações antioxidantes, por reduzirem a produção de espécies reativas de oxigênio e o fator de crescimento endotelial vascular (FCEV) que é responsável pela angiogênese, pois a camomila através de seus constituintes químicos é capaz de impedir a ativação dos receptores de FECV e desta forma a vascularização é reduzida (Al-Dabbagh et al, 2019;Ebrahimi et al, 2019).…”

“…Essa tendência pode ser explicada por diferentes fatores, como o alto custo dos medicamentos industrializados, os efeitos indesejáveis dos medicamentos sintéticos e o próprio modismo.Uma revisão sistemática realizada com o objetivo de investigar o uso das terapias alternativas para o tratamento da STPM incluiu 27 estudos que avaliaram uso de ervas (7 estudos), homeopatia (1 estudo), suplementos dietéticos (13 estudos), relaxamento (1 estudo), massagem (1 estudo), reflexologia (1 estudo), quiroprática (1 estudo) e biofeedback (2 estudos) que mostram a importância desta pratica integrativa. (Ministério da Saúde 2018;Brilhante et al, 2010).A camomila (Matricaria recutita), na sua composição tem óleos essenciais (alfabisabolol; camazuleno), matricina (flavonoidesapigenina e quercitina), aminoácidos, cumarinas (doxicumarina, herniarina e umbeliferona), ácidos orgânicos e vitamina C. Esta constituição química lhe confere ações antiespasmódica, antiflogística, calmante, cicatrizante, refrescante, anti-séptica e anti-inflamatória(Al-Dabbagh et al, 2019). A atividade terapêutica é determinada tanto pelos princípios ativos lipofílicos (solúveis em lipídios ou em álcoois)…”

Effect of Solvents on Phytochemical Composition and Antioxidant Activity of Cardiospermum halicacabum (L.) Extracts

“…Recently, interest has increased substantially in finding natural antioxidants for medicinal values and to substitute synthetic antioxidants, which has its limitations of reported carcinogenic effects. [2][3][4][5] Oxidative stress and generation of reactive oxygen species (ROS) damages the cell and has been identified to cause extensive damage in tissues leading to various chronic diseases, various degenerative disorders, ageing, cardiovascular diseases, diabetes, Alzheimer's disease, cancer etc. [6][7][8][9][10][11] Oxidative stress also has the ability to cause undesirable effects on food, making it unfit for consumption.…”

Comparison of in vitro antioxidative activities of crude methanolic extracts of three species of Passiflora from greenhouse using DPPH, ABTS and FRAP methods

“…Some popular plant substances such as chemical compounds and extracts, i.e. from Camelia sinensis [1], Crataegus oxyacantha [2], Echinacea purpurea [3], Matricaria recutita [4], Rosa sp. [5], Oryza sativa [6], Rosmarinus officinalis [2,7], Vitis vinifera [8] are still being investigated.…”