Antioxidant and Anti-Stress Effects of Taurine Against Electric Foot-Shock-Induced Acute Stress in Rats

Lee, Dong-Sung; Jo, Hee-Geun; Kim, Min Ji; Lee, Hwan; Cheong, Sun Hee

doi:10.1007/978-981-13-8023-5_17

Cited by 6 publications

(4 citation statements)

References 32 publications

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“…Chronic stress has been described as a risk factor for cardiovascular diseases (Lagraauw, Kuiper et al 2015), liver diseases (Russ, Kivimaki et al 2015;Kang, Zhao et al 2020) and obesity (Stefanaki, Pervanidou et al 2018). In addition, redox imbalance upon stress exposure has been described in organs such as the liver (Zaidi, Al-Qirim et al 2005;Ohta, Chiba et al 2007;Cakir, Kasimay et al 2010;Kaida, Ohta et al 2010;Kour and Bani 2011;Kalaz, Evran et al 2012;Demirdas, Naziroglu et al 2016;Kim, Oh et al 2016;Samarghandian, Farkhondeh et al 2016;Samarghandian, Azimi-Nezhad et al 2017b;Yi and Kim 2017;Lee, Jo et al 2019), the gastrointestinal tract (Cakir, Kasimay et al 2010;Banji, Banji et al 2014), the kidneys (Demirdas, Naziroglu et al 2016;Samarghandian, Farkhondeh et al 2016;Samarghandian, Azimi-Nezhad et al 2017b;Chen, Feng et al 2018), the pancreas (Lopez-Lopez, Jaime et al 2016) and the muscles (Hasan, Bilal et al 2011;Hussien, El-Wakeel et al 2019). It has been suggested that the stress-induced redox imbalance in peripheral organs is mediated by glucocorticoids (Zafir and Banu 2009b) as well as catecholamines and adrenoceptors (Zhu, Gu et al 2014).…”

Section: Conclusion and Discussionmentioning

confidence: 99%

Therapeutic potential of glutathione-enhancers in stress-related psychopathologies

Zalachoras

Hollis

Ramos-Fernández

et al. 2020

Neuroscience & Biobehavioral Reviews

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Section: Conclusion and Discussionmentioning

confidence: 99%

Therapeutic potential of glutathione-enhancers in stress-related psychopathologies

Zalachoras

Hollis

Ramos-Fernández

et al. 2020

Neuroscience & Biobehavioral Reviews

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“…We found that T-X exhibited potent scavenger activities against DPPH and ABTS, as well as reducing power, in vitro. Similarly, taurine showed significant scavenging activities against DPPH and alkyl radicals 26 .…”

Section: Discussionmentioning

confidence: 89%

Antioxidant and laxative effects of taurine-xylose, a synthetic taurine-carbohydrate derivative, in loperamide-induced constipation in Sprague-Dawley rats

Kim

Moon

et al. 2019

JENB

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In this study, we examined the in vitro antioxidant activities and laxative effects of taurine-xylose (T-X), a synthetic taurine-carbohydrate derivative, in a rat model of constipation induced by loperamide.[Methods] The animals were divided into four treatment groups: normal untreated rats (NOR group), loperamide-treated control rats (CON group), loperamide and taurine-xylose (15 mg/kg)-treated rats (T-X group), and loperamide and commercial Dulcolax S (5.5 mg/ kg)-treated rats (DS group).[Results] In the present study, T-X exhibited potent reducing power and free radical scavenging activities for DPPH (1,1-diphenyl-2-picrylhydrazyl) and ABTS+ (2,2′-azino-bis (3-ethylbenzothiazoline 6-sulfonic acid ammonium salt) radicals. The laxative effects of T-X were dependent on food, body weight, fecal properties, gastrointestinal transit (GIT) ratio, and serum metabolic parameters. In the T-X group, the number, wet weight, and water content of fecal pellets were noticeably increased compared to those in the loperamide-induced group. T-X treatment significantly increased the activities of hepatic antioxidant enzymes, including those of glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), and catalase (CAT), relative to those in loperamide-induced constipated rats. Furthermore, the GIT ratio and loperamide-induced metabolic parameters in serum, including gastrin (GAS), motilin (MTL), and somatostatin (SS) levels, were significantly improved by T-X treatment.[Conclusion] These results suggest that taurine-xylose exerts antioxidant activities and laxative effects on loperamide-induced constipation by promoting gastrointestinal motility.

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“…Taurine supplementation markedly increases the hepatic glutathione (GSH) levels, compared to the levels in the stress group. In addition, activities of antioxidant enzymes such as catalase (CAT), glutathione peroxidase (GPx) and glutathione-S-transferase (GST) were improved in the taurine-treated group (Lee et al, 2019). This could mean that taurine plays a more important role in protection against oxidative stress than GSH.…”

Section: Resultsmentioning

confidence: 99%

Analysis Of The Influence Of Alcohol-Induced Stress On The Quantitative And Qualitative Composition Of Amino Acids Related To S-Adenosylmethionine And Glutathione Transformations

2021

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Studies of preparations that decrease oxidative stress and, as a consequence, that can prevent or reduce the development of alcoholic liver disease are relevant. A wide range of drugs, the bioprotective effect of which is studied, in its action is associated with natural antioxidant systems. Therefore, the study of the features of these systems is necessary for the effective development of bio protectors. The aim is to analyze changes in the quantitative and qualitative composition of amino acids involved in antioxidant mechanisms in the presence of alcohol-induced stress in rats. In the presence of alcohol-induced oxidative stress, there are changes in the quantitative and qualitative composition of amino acids (methionine, serine, taurine), which are involved in the mechanisms of antioxidant protection - cycles of S-adenosylmethionine and glutathione. A slight increase in methionine levels in the blood serum of animals of the experimental group and disruption of the recovery cycle of methionine under alcohol-induced oxidative stress are arguments for the ineffectiveness of S-adenosylmethionine as a bioprotective substance. The same decrease in the level of serine (by 15%) and taurine (by 13%), and analysis of literature data, may be indicate the "secondary" nature of glutathione as an antioxidant compared to taurine.

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Antioxidant and Anti-Stress Effects of Taurine Against Electric Foot-Shock-Induced Acute Stress in Rats

Cited by 6 publications

References 32 publications

Therapeutic potential of glutathione-enhancers in stress-related psychopathologies

Therapeutic potential of glutathione-enhancers in stress-related psychopathologies

Antioxidant and laxative effects of taurine-xylose, a synthetic taurine-carbohydrate derivative, in loperamide-induced constipation in Sprague-Dawley rats

Analysis Of The Influence Of Alcohol-Induced Stress On The Quantitative And Qualitative Composition Of Amino Acids Related To S-Adenosylmethionine And Glutathione Transformations

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