Analysis Of The Influence Of Alcohol-Induced Stress On The Quantitative And Qualitative Composition Of Amino Acids Related To S-Adenosylmethionine And Glutathione Transformations

Abstract

Studies of preparations that decrease oxidative stress and, as a consequence, that can prevent or reduce the development of alcoholic liver disease are relevant. A wide range of drugs, the bioprotective effect of which is studied, in its action is associated with natural antioxidant systems. Therefore, the study of the features of these systems is necessary for the effective development of bio protectors. The aim is to analyze changes in the quantitative and qualitative composition of amino acids involved in antioxidant mechanisms in the presence of alcohol-induced stress in rats. In the presence of alcohol-induced oxidative stress, there are changes in the quantitative and qualitative composition of amino acids (methionine, serine, taurine), which are involved in the mechanisms of antioxidant protection - cycles of S-adenosylmethionine and glutathione. A slight increase in methionine levels in the blood serum of animals of the experimental group and disruption of the recovery cycle of methionine under alcohol-induced oxidative stress are arguments for the ineffectiveness of S-adenosylmethionine as a bioprotective substance. The same decrease in the level of serine (by 15%) and taurine (by 13%), and analysis of literature data, may be indicate the "secondary" nature of glutathione as an antioxidant compared to taurine.