Antioxidant and anti-inflammatory properties of alpha-lipoic acid protect against valproic acid–induced liver injury

Mohammed, Marwa; Gharib, Doaa M.; Reyad, Hoda Ramadan; Mohamed, Alaa Aboud; Elroby, Fadwa A.; Mahmoud, Hoda Sayed

doi:10.1139/cjpp-2019-0456

Cited by 8 publications

(4 citation statements)

References 67 publications

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“…Oxidative stress is also responsible for TNF‐α and JNK activation associated inflammation and necrosis 56,57 . SV was shown to mediate hepatotoxicity via TNF‐α, and NF‐κB activation and increased IL‐6 and COX‐2 expressions in experimental animals 26,58–60 . Consistent with the above studies, this study also reports increased pro‐inflammatory marker expression upon SV administration.…”

Section: Discussionsupporting

confidence: 88%

“…IL-6, interleukin-6; NF-κB, nuclear factor kappa B; JNK, c-Jun N-terminal Kinase; IKKB, Inhibitor of nuclear factor kappa-B kinase subunit beta; SIL-silymarin and JNK activation associated inflammation and necrosis 56,57. SV was shown to mediate hepatotoxicity via TNF-α, and NF-κB activation and increased IL-6 and COX-2 expressions in experimental animals 26,[58][59][60]. Consistent with the above studies, this study also reports increased pro-inflammatory marker expression upon SV administration.…”

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confidence: 99%

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Syringic acid and silymarin concurrent administration inhibits sodium valproate‐induced liver injury in rats

Gheena

Ezhilarasan

Harini

et al. 2022

Environmental Toxicology

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Sodium valproate (SV) is a well‐known anti‐epileptic drug, also used to control convulsions, bipolar disorders and migraines. SV has been shown to induce liver toxicity in clinical subjects. Syringic acid (SA), a natural polyphenolic compound has potential antioxidant, anti‐inflammatory and several beneficial effects. Therefore, in this study, we evaluated hepatoprotective effect of SA against SV‐induced liver injury in rats. Wistar rats were treated with SV orally at a dose of 500 mg/kg, once daily, for 14 days. Another three groups of rats were administered with SV and concurrently treated with SA (40 and 80 mg/kg) and silymarin (SIL) (100 mg/kg) for 14 days. SV administration for 14 days caused significant (p < .001) elevation of liver transaminases and ALP in serum. Liver MDA level was significantly (p < .001) increased with a concomitant decrease (p < .001) in enzymic antioxidants activities in SV administered rats. SV administration also caused the upregulation of proinflammatory markers such as tumor necrosis factor α, c‐Jun N‐terminal kinase, nuclear factor kappa B, cyclooxygenase‐2 and Interleukin 6 expressions in liver tissue. Histopathological studies also revealed the presence of inflammatory cell infiltration and hepatocellular necrosis upon SV administration. At both doses, concurrent administration of SA and SIL significantly (p < .001) inhibited the liver transaminase activities in serum, oxidative stress, and proinflammatory markers expression in liver tissue. Our current results suggest that SA can be a promising herbal drug that can inhibit SV‐induced hepatotoxicity when administered together due its potential anti‐inflammatory effects.

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Section: Discussionsupporting

confidence: 88%

mentioning

confidence: 99%

Syringic acid and silymarin concurrent administration inhibits sodium valproate‐induced liver injury in rats

Gheena

Ezhilarasan

Harini

et al. 2022

Environmental Toxicology

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“…In the model of mouse inflammatory bowel diseases (IBD), ALA was found to reduce the plasma levels of LPS and systemic inflammation in mice with colitis [ 54 ]. In human health-related studies, ALA was found to reduce the TNF-α and IL-6 levels in many organs and tissues through its anti-inflammatory properties [ 49 , 55 ]. Another study indicated a beneficial effect of ALA administration by reducing the serum and liver levels of TNF-α and IL-1β in rabbits fed oxidized nutrition oils [ 48 ].…”

Section: Discussionmentioning

confidence: 99%

R- Is Superior to S-Form of α-Lipoic Acid in Anti-Inflammatory and Antioxidant Effects in Laying Hens

Liu

Huang

et al. 2022

Antioxidants

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The development of single enantiomers with high efficiency and low toxic activity has become a hot spot for the development and application of drugs and active additives. The aim of the present study was to investigate the effectiveness of the application of α-lipoic acid with a different optical rotation to alleviate the inflammation response and oxidative stress induced by oxidized fish oil in laying hens. Sixty-four 124-week-old Peking Red laying hens were randomly allocated to four groups with eight replicates of two birds each. The normal group was fed basal diets supplemented with 1% fresh fish oil (FO), and the oxidative stress model group was constructed with diets supplemented with 1% oxidized fish oil (OFO). The two treatment groups were the S-form of the α-lipoic acid model with 1% oxidized fish oil (OFO + S-LA) and the R-form of the α-lipoic acid model with 1% oxidized fish oil (OFO + R-LA) added at 100 mg/kg, respectively. Herein, these results were evaluated by the breeding performance, immunoglobulin, immune response, estrogen secretion, antioxidant factors of the serum and oviduct, and pathological observation of the uterus part of the oviduct. From the results, diets supplemented with oxidized fish oil can be relatively successful in constructing a model of inflammation and oxidative stress. The OFO group significantly increased the levels of the serum inflammatory factor (TNF-α, IL-1β, IL-6, and IFN-γ) and the oxidative factor MDA and decreased the activity of the antioxidant enzyme (T-AOC, T-SOD, GSH-Px, GSH, and CAT) in the oviduct. The addition of both S-LA and R-LA significantly reduced the levels of serum inflammatory factors (TNF-α, IL-1β, IL-6, and IFN-γ), increased the activity of antioxidant indexes (T-AOC, T-SOD, GSH-Px, GSH, and CAT), and decreased the MDA contents in the serum and oviduct. Meanwhile, the supplementation of S-LA and R-LA also mitigated the negative effects of the OFO on the immunoglobulins (IgA and IgM) and serum hormone levels (P and E2). In addition, it was worth noting that the R-LA was significantly more effective than the S-LA in some inflammatory (IL-1β) and antioxidant indices (T-SOD, GSH, and CAT). Above all, both S-LA and R-LA can alleviate the inflammation and oxidative damage caused by oxidative stress in aged laying hens, and R-LA is more effective than S-LA. Thus, these findings will provide basic data for the potential development of α-lipoic acid as a chiral dietary additive for laying hens.

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“…25 Alpha-lipoic acid also protects against valproic acid-induced liver injury. 26 The combination of ALA, acetyl-L-carnitine (ALCAR), and coenzyme CoQ10 may provide an effective strategy in preventing anti-TB DILI. 27 ALA and silymarin treatment ameliorate thioacetamide (TAA)-induced oxidative damage,alterations in the liver function tests and liver histopathology in male albino rats.…”

Section: Introductionmentioning

confidence: 99%

The Potential of Alpha Lipoic Acid to Maintain Liver Function Tests in XenobioticInduced Liver Toxicity: A Narrative Review

2022

TJNPR

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benefits including a protect effect on the liver. The present review is an up-to-date paper of current thinking regarding ALA and its use in providing antioxidant drug therapy on the potential role of ALA on xenobiotic-induced liver injury. Chemistry of ALALA is also called thioctic acid and is chemically named 1,2-dithiolane-3-pentanoic acid (C8H14O2S2): with an oxidized (disulfide, LA) and a reduced (di-thiol: dihydro-lipoic acid, (Fig. 1) DHLA) form of LA. 6 Figure 1: Chemical structures of lipoic acid (LA), dihydrolipoic acid (DHLA), and lipoyllysine (LA attached to biologic lysine residues);*, the structure contains a chiral center.

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Antioxidant and anti-inflammatory properties of alpha-lipoic acid protect against valproic acid–induced liver injury

Cited by 8 publications

References 67 publications

Syringic acid and silymarin concurrent administration inhibits sodium valproate‐induced liver injury in rats

Syringic acid and silymarin concurrent administration inhibits sodium valproate‐induced liver injury in rats

R- Is Superior to S-Form of α-Lipoic Acid in Anti-Inflammatory and Antioxidant Effects in Laying Hens

The Potential of Alpha Lipoic Acid to Maintain Liver Function Tests in XenobioticInduced Liver Toxicity: A Narrative Review

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