The Potential of Alpha Lipoic Acid to Maintain Liver Function Tests in XenobioticInduced Liver Toxicity: A Narrative Review

Abstract

benefits including a protect effect on the liver. The present review is an up-to-date paper of current thinking regarding ALA and its use in providing antioxidant drug therapy on the potential role of ALA on xenobiotic-induced liver injury. Chemistry of ALALA is also called thioctic acid and is chemically named 1,2-dithiolane-3-pentanoic acid (C8H14O2S2): with an oxidized (disulfide, LA) and a reduced (di-thiol: dihydro-lipoic acid, (Fig. 1) DHLA) form of LA. 6 Figure 1: Chemical structures of lipoic acid (LA), dihydrolipoic acid (DHLA), and lipoyllysine (LA attached to biologic lysine residues);*, the structure contains a chiral center.

The Role of Alpha Lipoic Acid and Tempol Against Liver Injury after Acetaminophen Subacute Exposure in Mice

“…Overall, the evidence suggests that Tempol has the ability to restore normal liver function in mice with APAP-induced acute hepatotoxicity by activating the PI3K/Akt/Nrf2 pathway, thereby enhancing the antioxidant response and inhibiting hepatic apoptosis. Studies have provided evidence that lipoic acid exhibits a potential therapeutic benefit in treating the liver structural and chemical aberrations instigated by an overdose of the analgesic drug APAP in male albino mice (Tiiba et al, 2022). Besides, studies have revealed that lipoic acid possesses the ability to prevent APAP-induced liver damage by reducing necrosis, inflammation, and oxidative stress in the liver and promoting liver regeneration.…”