Antioxidant and anti-cytolytic activity of parsnip (Pastinaca sativa L.) herb thick extract in conditions of catecholamine myocardiodystrophy in rats

Symonenko, N. A.; Shpychak, О. S.; Mishchenko, O. Ya.; Kyslychenko, V. S.; Shpychak, Tamara; Гращенкова, С. А.

doi:10.15587/2519-4852.2022.253546

Cited by 4 publications

(8 citation statements)

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“…Як об'єкт дослідження використано рослинну субстанцію пастернаку посівного трави екстракту густого (ППТЕГ) (Pastinacae sativae herbae extractum spissum). Згідно з вимогами (Методи контролю якості -МКЯ), це в'язка маса коричневого кольору з ароматним запахом, легкорозчинна в воді, розчинна в етанолі, майже нерозчинна в гліцерині, рослинних і мінеральних оліях, нерозчинна в хлороформі й етилацетаті [15,16]. Випробування здійснили, використавши дозволені до медичного застосування допоміжні речовини: целюлозу мікрокристалічну, крохмаль картопляний, кросповідон XL 10, кремнію діоксид колоїдний (аеросил) [17].…”

Section: матеріали і методи дослідженняunclassified

Development of industrial technology of tablets with cardioprotective action based on cultivated parsnip herb thick extract

Symonenko¹,

Shpychak²,

Bezrukavyi³

2023

АП

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The aim of the work is to develop the industrial technology of tablets with cardioprotective action based on the domestic raw material of cultivated parsnip herb thick extract (CPHTE). Materials and methods. Experimental samples of mixtures of the plant substance CPHTE (Pastinacae sativae herbae extracti spissi) with excipients approved for medical application were used as objects of the study. Results. The results of experimental studies were used during the development of a block diagram of the technological process to produce tablets with cardioprotective action based on the plant raw material CPHTE and an apparatus scheme was tested in the industrial conditions of LLC “Pharmaceutical Company “Zdorovye” (Kharkiv); the control technological parameters for each stage of the technological process of medicine preparation were established. Conclusions. The technology to produce cardioprotective tablets based on the domestic raw material CPHTE was theoretically substantiated and experimentally developed, as well as a block diagram of the technological process of their production and an apparatus scheme tested in industrial conditions by the LLC “Pharmaceutical Company “Zdorovye” (Kharkiv). The results of the experiment were used while development of projects of quality control methods and technological regulations for the developed medicine in the form of tablets under the conventional name “Pastinocard”.

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Section: матеріали і методи дослідженняunclassified

Development of industrial technology of tablets with cardioprotective action based on cultivated parsnip herb thick extract

Symonenko¹,

Shpychak²,

Bezrukavyi³

2023

АП

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“…Furthermore, furanocoumarins extracted from parsnips have the ability to dilate peripheral vessels and coronary vessels of the heart, eliminate spasms of the bronchi and smooth muscles of the abdominal cavity, and have a moderate sedative effect. In addition, P. sativa exhibits antioxidant and anticytolytic activities [108].…”

Section: Pastinaca Sativa L Seler Family -Apiaceaementioning

confidence: 99%

Medicinal Plants of the Flora of Kazakhstan Used in the Treatment of Skin Diseases

Berganayeva¹,

Kudaibergenova²,

Litvinenko³

et al. 2023

Preprint

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According to the eminent scholar, philosopher, and physician Avicenna, "the doctor has three tools: the word, the plant, the knife." The plant kingdom is recognized as humanity's earliest and most ancient healing source, employed for the management and prevention of illnesses. Tracing back through history, the most ancient documented proof of plants' utilization in medicine dates back to a Sumerian clay slab discovered in Nagpur roughly 5000 years ago. This artifact included a compilation of twelve medicinal recipes that involved over 250 diverse plant species. Sumerian healers extracted powders and infusions from plant roots and stems, while also crediting healing properties to pears and figs. Additionally, they utilized dried and ground young shoots of willow and plum trees, pine and fir needles as a component in compresses and poultices. Often, powders from animal and mineral sources were blended with those extracted from dried and crushed plants. Notably, in addition to water, wine and beer served as solvents. Thus, at least 80 centuries ago, people utilized the most uncomplicated medicinal plant-based preparations for treatment [1]. The "Pen T'Sao," an ancient Chinese text on roots and herbs, authored by Emperor Shen Nung approximately 2500 BC, contains descriptions of 900 medicaments (comprising dried components of medicinal plants). Several of these substances are still in use today, including Rhei rhisoma, camphor, Theae folium, Podophyllum, great yellow gentian, ginseng, datura, cinnamon bark, and ephedra [2]. Regarding Kazakh folk medicine, an area that has yet to be fully explicated and substantiated, it can be stated that the traditional medicinal knowledge of the Kazakh people transcends the mere treatment of ailments and rests on robust theoretical underpinnings. Oteiboydak Tleukabyluly (1388-1478), an astute healer and prominent figure in Kazakh folk medicine during the 15th century, comprehensively explicated the secrets of the healing art in his medical and ethnographic work "Medical Narrative," which he composed between 1466 and 1473 at the behest of az-Zhanibek Khan, who held him in high esteem as a great healer. This medical encyclopedia delineates the functions of various organs of the human body and provides a catalogue of the primary diseases associated with them. Furthermore, it includes a meticulous description of the methods used in traditional medicine at present, such as setting bones, listening to the pulse, and incantations. Through practical experimentation and experimentation conducted in the steppe laboratory, the healer formulated a total of 1,108 different medicinal compounds, of which 858 were derived from medicinal plants, 318 were extracted from animal organs, and roughly 60 were sourced from metals. The moniker "Teacher without a teacher" was bestowed on Oteiboydak Tleukabylov, who discovered methods for treating 1,050 different diseases [3]. At present, the employment of phytotherapy has gained widespread acceptance on a global scale. According to the World Health Organization's (WHO) global review of national policies concerning traditional, complementary, and alternative medicine, as well as the regulation of herbal medicines, there is an evident growth in the European and Asian market for herbal medicines [4]. Kazakhstan boasts a natural flora of over 6,000 plant species [5]. The exact number of medicinal plant species present in Kazakhstan remains uncertain, as the list continues to expand annually. More than 150 plant species have been employed in both official and folk medicine for various ailments. This review focuses on a selection of medicinal plants growing within the territory of the Republic of Kazakhstan that have traditionally been used to alleviate skin diseases. In conducting this study (2010-2023), emphasis was placed on the plants' phytochemical composition, with a particular focus on the principal components responsible for their therapeutic effects against inflammatory skin conditions such as dermatitis, atopic dermatitis, and eczema.

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“…Як об'єкт дослідження використали експериментальні зразки сумішей рослинної субстанції пастернаку посівного трави екстракту густого (ППТЕГ) -(Pastinacae sativae herbae extractum spissum) з дозволеними до медичного застосування групами допоміжних речовин [4]. Згідно з методиками контролю якості, ППТЕГ являє собою в'язку масу коричневого кольору з ароматним запахом, що легкорозчинна у воді, розчинна в етанолі, майже нерозчинна у гліцерині, рослинних і мінеральних оліях, не розчинна в хлороформі й етилацетаті [2,5].…”

Section: матеріали і методи дослідженняunclassified

“…Про це свідчать останні наукові публікації щодо інноваційних підходів до способів екстрагування лікарської рослинної сировини та одержання на її основі фітоекстрактів з різними видами апаратурного обладнання, що призначене для вилучення біологічно активних речовин (БАР) під час екстрагування. Крім того, бази даних цих речовин постійно оновлюють [1,2].…”

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Justification of the choice of excipients during the development of the composition of “Pastinocard” tablets

Symonenko,

Shpychak,

Kukhtenko

et al. 2023

CIPM

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The aim of the work is to justify the choice of excipients as components for the cardioprotective medicine “Pastinocard” tablets based on the domestic raw material of cultivated parsnip herb thick extract (CPHTE). Materials and methods. Experimental test samples of mixtures of the plant substance of domestic origin CPHTE with groups of excipients, approved for medical use, were used as the object of research. Results. We conducted experimental research by a mathematical planning method called the Greek–Latin square. In this study, we investigated how 16 different auxiliary substances affected the pharmacotechnological properties of tableting masses and tablets made from PPTEG with cardioprotective properties. Our goal was to determine the optimal composition and manufacturing process for a medication, specifically “Pastinocard” tablets. We also developed project plans for manufacturing regulations and quality control methods, which we successfully tested in the industrial production setting at Pharmaceutical Company “Zdorovye”, LTD in Kharkiv. Conclusions. The formulation for cardioprotective tablets, designated as “Pastinocard”, has been both theoretically justified and experimentally developed by domestic CPHTE raw materials. These research findings have been instrumental in crafting the regulatory documentation for quality control and the production processes of the resulting tablet medication.

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Antioxidant and anti-cytolytic activity of parsnip (Pastinaca sativa L.) herb thick extract in conditions of catecholamine myocardiodystrophy in rats

Cited by 4 publications

References 4 publications

Development of industrial technology of tablets with cardioprotective action based on cultivated parsnip herb thick extract

Development of industrial technology of tablets with cardioprotective action based on cultivated parsnip herb thick extract

Medicinal Plants of the Flora of Kazakhstan Used in the Treatment of Skin Diseases

Justification of the choice of excipients during the development of the composition of “Pastinocard” tablets

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