Antioxidant and anti-apoptotic effects of selenium nanoparticles against murine eimeriosis

Abstract

Eimeriosis is caused by a protozoan parasite of the genus Eimeria and infection affecting most domestic animal species. The aim of this research was to comprehend the impact of selenium nanoparticles (SeNPs) on eimeriosis induced by Eimeria papillata in mouse jejunum, and how they work as antioxidants and antiapoptotic agents against eimeriosis. The numbers of meronts, gamonts, and developing oocysts of E. papillata reduced after the infected mice were treated with the SeNPs. The levels of malondialdehyde (MDA), nitric oxide (NO), and other oxidative stress-related molecules, such as glutathione (GSH), catalase (CAT), and superoxide dismutase (SOD), were assayed. E. papillata was able to change the redox status of the jejunal cells; this was confi rmed by the elevation of the MDA and NO levels, and the decrease of the GSH levels and the activities of the antioxidant enzymes CAT and SOD. SeNP treatment signifi cantly reversed this disturbance of the redox status. The expression levels of the apoptotic markers Bax and caspase-3 in the jejunal samples were evaluated using qRT-PCR. The SeNPs decreased the Bax and caspase-3 expression after being administered to the E. papillata-infected mice. Collectively, the SeNPs demonstrated antioxidant and anti-apoptotic activities against murine eimeriosis.

Selenium Nanoparticles by Moderating Oxidative Stress Promote Differentiation of Mesenchymal Stem Cells to Osteoblasts

“…The FTIR spectrum, which represented symmetric and asymmetric vibration bands of the SeNPs, showed a broad peak at 3200-3500 cm -1 , indicating the presence of the amide (-NH) group, while a strong peak at 1637 cm -1 corresponded to the C=O group. 23 The peak at 767.5 cm -1 was related to the stretching mode of the metal peaks of Se ( Figure 1C).…”

The Advancing of Selenium Nanoparticles Against Infectious Diseases

“…Se NPs are found to be more effective than sodium selenite with regard to their anti-coccidial, anti-oxidant, anti-apoptotic and anti-inflammatory role against Eimeria parasite in the jejunum of mice (Alkhudhayri et al, 2018;Alkhudhayri et al, 2020). Furthermore, Dkhil et al demonstrated the protective roles of Se NPs in mice infected with Schistosoma mansoni, indicating that Se NPs could possess therapeutic anti-schistosomal activity in the treatment of intestinal schistosomiasis (Dkhil et al, 2019).…”

Assessment of the oxidative status and goblet cell response during eimeriosis and after treatment of mice with magnesium oxide nanoparticles

“…Recently, specific forms of nanomaterials have been produced including metals such as silver, gold, copper, zinc and magnesium, creating various degrees of antimicrobial activity ( Hussein et al, 2018 ). Moreover, Alkhudhayri et al (2020) reported the antioxidant and the antiparasitic effect of nanoselenium.…”