Antioxidant and Analgesic Activities of Lannea coromandelica Linn. Bark Extract

Alam, Badrul; Hossain, Sarowar; Habib, Razibul; Rea, Julia; Islam, Anwarul

doi:10.3923/ijp.2012.224.233

Cited by 17 publications

(7 citation statements)

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“…The extract significantly reduced mouse writhing at the highest dose only. The extracts probable effects on prostaglandin activity as reported from anti-inflammatory studies may have also partly resulted in the decrease in the number of writhes as prostaglandins play a role in the acetic acid induced writhing test [42]. Earlier reports by Dubois and his colleagues revealed that the stem bark of C. barteri possessed sedative activity and they attributed this sedative effect to the presence of saponins.…”

Section: Discussionmentioning

confidence: 96%

Preliminary assessment of the anti-inflammatory and analgesic effects of methanol leaf extract of Cussonia barteri (Araliaceae) in rodents

et al. 2019

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Introduction: Potato (Solanum tuberosum L.) is an important vegetable crop in Syria. Potato tuber moth Cussonia barteri is a small tree that grows in the sub-Saharan part of Africa. Various parts of the plant are used for the treatment of a variety of ailments in ethno-medicine.Objective: To evaluate the anti-inflammatory and analgesic effect of the methanol leaf extract of Cussonia barteri. Material and methods:The leaves were air-dried, powdered and repeatedly extracted with methanol using a Soxhlet apparatus. The resulting methanol extract (100, 200 and 400 mg/kg) was evaluated for antiinflammatory activity using carrageenan-induced paw oedema, xylene-induced ear oedema and formalininduced arthritis tests. Analgesic effect was evaluated using acetic acid-induced mouse writhing, hot plate and tail flick tests.Results: All doses of the extract significantly (p<0.05) reduced carrageenan-induced paw oedema, however the 400 mg/kg dose gave a sustained effect. The extract significantly inhibited xylene induced ear oedema at all doses. There were no significant (p>0.05) reductions in paw swellings due to formalin. In the acetic acid induced writhing test, the extract significantly (p<0.05) decreased writhing at 400 mg/kg only. Reaction times were not significantly different from the control in the hot plate and tail flick tests. Conclusion:This study has shown that the methanol extract possesses acute anti-inflammatory and peripherally mediated analgesic effects.Swiss albino mice (20-30 g) and Wistar rats (150-180 g) of either sexes were purchased at the Department of Pharmacology Animal House, University of Benin. They were housed in polypropylene cages, had free access to clean drinking water and pelletized feed.

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Section: Discussionmentioning

confidence: 96%

Preliminary assessment of the anti-inflammatory and analgesic effects of methanol leaf extract of Cussonia barteri (Araliaceae) in rodents

et al. 2019

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“…Masyarakat Suku Buton, Sulawesi telah memanfaatkan tanaman ini sebagai obat tradisional untuk hematemesis, diare, dan scabies (Indrayangingsih et al, 2015). Beberapa penelitian sebelumnya melaporkan bahwa bagian kulit kayu dan daun tanaman ini memiliki potensi sebagai antibakteri (Ismail et al, 2016), anti-jamur (Kaur et al, 2013), antioksidan, analgesik (Alam et al, 2012;2017), dan mempercepat penyembuhan luka pada tikus putih (Calsum et al, 2018). Hal tersebut disebabkan adanya berbagai kandungan bioaktif hasil metabolit sekunder tanaman Kayu Jawa seperti fenol, terpenoid, dan flavonoid (Fadliah et al, 2018;Kaur et al, 2012;Kumar & Jain, 2015).…”

Section: Pendahuluanunclassified

Aktivitas Antibakteri Kapang Endofit dari Tangkai Daun Tanaman Kayu Jawa (Lannea coromandelica)

Bahri

Amelia

Ningrum

et al. 2022

Al-Kauniyah J. Biol.

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AbstrakKapang endofit telah banyak ditemukan pada berbagai jaringan tanaman. Pemanfaatan kapang endofit dapat menjadi solusi untuk mengurangi eksploitasi tumbuhan yang berpotensi sebagai sumber senyawa bioaktif. Penelitian ini bertujuan untuk mengetahui keberadaan kapang endofit pada tangkai daun tanaman Kayu Jawa Lannea coromandelica dan potensinya sebagai agen antibakteri. Isolasi dilakukan dari tangkai tanaman Kayu Jawa dan isolat yang berhasil diperoleh dikarakterisasi secara makroskopis dan mikroskopis. Uji penapisan pada semua isolat dengan bakteri Staphylococcus aureus dan Pseudomonas aeruginosa untuk mendapatkan isolat yang berpotensi sebagai agen antibakteri. Ekstraksi isolat terpilih dilakukan dengan pelarut metanol (MeOH) dan pelarut etil asetat (EtOAc). Pengujian antibakteri menggunakan tiga bakteri uji, yaitu Staphylococcus aureus, Pseudomonas aeruginosa, dan Salmonella typhi. Hasil penelitian terdapat enam isolat yang berada di jaringan tangkai daun tanaman Kayu Jawa, yaitu PLC.1.A, PLC.1.B, PLC.2, PLC.3, PLC.4, dan PLC.5. Hasil uji penapisan menunjukkan isolat PLC.4 yang menjadi kandidat antibakteri pada penelitian ini. Fraksi MeOH memiliki aktivitas antibakteri lebih tinggi dibanding fraksi EtOAc pada semua bakteri uji dan kontrol positif (kloramfenikol) pada bakteri P. aeruginosa. Ekstrak MeOH isolat PLC.4 memiliki aktivitas antibakteri yang berpotensi sebagai sumber antibiotik baru.Abstract Endophytic fungi have been found in various plant tissues. The utilization of endophytic fungi can be a solution to reduce the exploitation of plants that are potential sources of bioactive compounds. This study aims to determine the presence of endophytic fungi on the petiole tissue of Kayu Jawa plants (Lannea coromandelica) and their potential as an antibacterial agent. Isolation and characterization of isolates was conducted macro- and microscopically. Screening test is carried out on the isolates against Staphylococcus aureus and Pseudomonas aeruginosa bacteria to obtain isolate that has the potential as an antibacterial agent. The extraction of selected isolates was carried out using methanol (MeOH) and ethyl acetate (EtOAc) solvents. Antibacterial examination used three test bacteria: Staphylococcus aureus, Pseudomonas aeruginosa, Salmonella typhi. The results showed that six isolates were found in the petiole tissue of L. coromandelica, namely, PLC.1.A, PLC.1.B, PLC.2, PLC.3, PLC.4, and PLC.5. Screening result showed that PLC.4 isolate was a candidate for antibacterial agent in this study. The MeOH fraction had higher antibacterial activity than the EtOAc fraction in all tested bacteria and from positive control (chloramphenicol) on P. aeruginosa bacteria. In conclusion, the MeOH extract of PLC.4 isolate has antibacterial activity potential as a source of new antibiotics.

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“…Barks should have anti-inflammatory, hypotensive, antihyperglycaemic, antimicrobial, antimicrobial, analgesic and antioxidant effects. [24][25][26][27][28][29][30][31][32] The aqueous extract of L. coromandelica antagonizes the glucagon receptor and has the ability to minimize the output of glucagon-mediated liver glucose and antinociceptive activity. 33,34 Quarcetin, (2S,3S,4R,10E)-2-[2'R)-2'-hdroxytetracosanoyl amino]-10-octadecene-1,3,4-triol, aralia cerebroside, 5,5'-dibuthoxy-2,2'-bifuran, β-sitostryl-3β-glucopyranoside-6'-O-palmitate, β-sitosterol palmitate, myricadiol, protocatechuic acid, p-hydroxy benzoic acid ethyl ester, isovanillin, trans-cinnamic acid, palmitic acid and steric acid were isolated from the barks of Lannea coromandelica.…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Screening, HPTLC Finger Print and in vitro Antioxidant Activity of Bark Extracts of Lannea coromandelica (Houtt.) Merr.

R¹

2021

IJPER

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Background: Lannea coromandelica Merr (Houtt.) is used as a common medicinal plant among the tribal communities of Bangladesh has long been used in indigenous medicine for curing certain health disorders. Phytochemicals present in the bark are associated with their therapeutic capabilities. Objectives: The study was aimed to evaluate the HPTLC finger printing and in vitro antioxidant activity of methanol extract (MELC) and aqueous extract (AELC) of L. coromandelica bark extracts. Materials and Methods: The study consists of parameters which includes moisture content, ash values and ethanol and water soluble extractive values. Results: HPTLC finger print assessment will help to identify and monitor the drug effectiveness and ensure therapeutic efficacy. Antioxidant activity was measured using in vitro methods such as total phenolic content, total flavanoid content, 1,1 diphenyl 2 picryl hydrazyl (DPPH) radical scavenging potential, ferric ion reduction assay and phosphomolybdenum assay at different concentrations. MELC showed a high phenolic, flavanoid content, higher DPPH free radical scavenging, lower antioxidant ability of ferric ions and a phosphorous molybdenum assay compared to that of standard. Conclusion: The presence of natural phytoconstituents which are responsible for antioxidant activity in plant extracts. This may aid in further extensive studies for identifying and isolating compounds with potential therapeutic value in Lannea coromandelica (Houtt.) Merr.

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Antioxidant and Analgesic Activities of Lannea coromandelica Linn. Bark Extract

Cited by 17 publications

References 0 publications

Preliminary assessment of the anti-inflammatory and analgesic effects of methanol leaf extract of Cussonia barteri (Araliaceae) in rodents

Preliminary assessment of the anti-inflammatory and analgesic effects of methanol leaf extract of Cussonia barteri (Araliaceae) in rodents

Aktivitas Antibakteri Kapang Endofit dari Tangkai Daun Tanaman Kayu Jawa (Lannea coromandelica)

Phytochemical Screening, HPTLC Finger Print and in vitro Antioxidant Activity of Bark Extracts of Lannea coromandelica (Houtt.) Merr.

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