Antioxidant and alpha‐amylase inhibitory potentials of Cocos nucifera husk

Abstract

Concoctions containing extract from Cocos nucifera husk fiber are used in Nigeria by traditional medicine practitioners for management of diabetes and its associated complications. Preliminary antidiabetic study was designed to validate the folkloric usage of the plant extract. Dried coconut husk fiber was pulverized and extracted with methanol, followed by partitioning of the methanolic extract in ethyl acetate. Phenolic content, radical scavenging activity and antioxidant capacity as well as inhibitory effects of C. nucifera methanolic (CN‐M) extract and its ethyl acetate (CN‐E) fraction on pancreatic α‐amylase and lipid peroxidation were determined. Total phenolic content and antioxidant capacity of CN‐E fraction were significantly higher than that of CN‐M extract, whereas there was no significant difference in their ability to scavenge free radicals. The CN‐E fraction also exhibited higher in vitro and in vivo inhibitory effects on α‐amylase activity and lipid peroxidation; reducing blood glucose level within 5 days following intraperitoneal administration of the C. nucifera extract to alloxan‐induced hyperglycemic rats. The phenolic‐rich extracts from coconut husk can be further explored as nutraceutical supplement in food formulation for diabetic patients.

Phytochemical composition and antioxidant activity of coconut cotyledon

“…The bioactivities viz., antiulcerogenic (Nneli and Woyike, 2008), wound healing (Srivastava andDurgaprasad, 2008), antimicrobial, anti-inflammatory, anti-diabetic, anti-neoplastic, anti-parasitic, insecticidal, leishmanicidal (Roopan, 2016), antioxidant (Muritala et al, 2018) and cell proliferation (Dhanyakrishnan et al, 2018) of one or more parts, such as coconut water, husk fiber, oil, flowers, spadix and mesocarp of coconut fruit are documented. However, the bioactivity of C. nucifera cotyledon has not been studied so far.…”

Up-to-Date Overview of the Use of Natural Ingredients in Sunscreens

“…Quercetin ( Figure 6 ), (+)-catechin, vanillic and caffeic acids, and (−)-epicatechin were detected and quantified by HPLC-MS analysis of the extract. All of the phenolic compounds were previously reported to exhibit antioxidant activity [ 111 , 112 ]. Regarding the photoprotective activity of the cream containing the C. nucifera extract and the cream containing quercetin, the SPF values varied between 5.0–14.09 and 1.44–15.04, respectively.…”

Inhibitory Effects against Alpha-Amylase of an Enriched Polyphenol Extract from Pericarp of Mangosteen (Garcinia mangostana)

“…Until now, modification of dietary habits and the use of drugs that prevent the digestion of starch seem to be the simplest modifiable and cost-effective methods. There is growing evidence showing that people with diets rich in foods containing a high content of polyphenols and high antioxidant capacity compounds may have a lower risk of T2DM [ 4 , 10 , 11 ]. Polyphenols have been demonstrated to be a considerable postprandial glycemic control in many experiments ro .…”

“…Many epidemiological studies have reported total antioxidant capacity may play an important role in reducing the risk of T2DM [ 7 , 8 ]. Recent studies have established that, as α-amylase inhibitors with excellent antioxidant activity, natural polyphenols could prevent or delay the onset of T2DM [ 9 , 10 , 11 , 12 , 13 ]. Therefore, dietary intervention with polyphenols may be a good strategy for improving diabetes or its complications.…”