Inhibitory Effects against Alpha-Amylase of an Enriched Polyphenol Extract from Pericarp of Mangosteen (Garcinia mangostana)

Li, Xiaofang; Chen, Haoze; Jia, Yan; Peng, Jinming; Li, Chunmei

doi:10.3390/foods11071001

Cited by 7 publications

(2 citation statements)

References 79 publications

(103 reference statements)

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“…Te study by Li et al in 2022 showed 20 and 40 mg/kg of oral pericarp extracts of G. mangostana to HFD-induced Sprague-Dawley (SD) rats an inhibitory efect on α-amylase activity and signifcantly reduced post-prandial blood glucose [48].…”

Section: Protective Efects Of Mangosteenmentioning

confidence: 99%

Mechanistic Insights into the Xanthones Present in Mangosteen Fruit (Garcinia mangostana) and Their Applications in Diabetes and Related Complications

Safaei,

Sakhaee,

Saberifar

et al. 2023

Journal of Food Biochemistry

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Diabetes mellitus is one of the leading public health problems, affecting about 10% of the population. Chronic complications of diabetes cause several human sufferings, including kidney failure, blindness, amputations, stroke, and myocardial infarction. Xanthones from mangosteen fruit (Garcinia mangostana) and their physiological effects, such as antiobesity, antihyperglycemic, antidyslipidemia, antidiabetic, and anti-inflammatory effects have been demonstrated in experimental studies to have beneficial effects on obesity, diabetes, hyperglycemic, dyslipidemia, and inflammatory states. It is worthwhile to mention that, in this context, the PubMed, Scopus, and Google Scholar databases have been searched for articles containing the keywords of “Garcinia mangostana,” “Mangosteen,” “α-mangostin,” “diabetes mellitus,” “diabetes complication,” “hypoglycemic,” “antihyperglycemic,” “antidiabetic,” and “without publication time limitation”. This study aims to review the in silico, in vitro, in vivo, and clinical pharmacological effects of mangosteen fruit and its xanthones on diabetes mellitus and its complications as well as their molecular pathways related to them. Taking into account the findings of these studies, we can say that mangosteen fruit and its xanthones hold significant potential for designing human studies for controlling and even modifying diabetes mellitus and its related diseases.

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Section: Protective Efects Of Mangosteenmentioning

confidence: 99%

Mechanistic Insights into the Xanthones Present in Mangosteen Fruit (Garcinia mangostana) and Their Applications in Diabetes and Related Complications

Safaei,

Sakhaee,

Saberifar

et al. 2023

Journal of Food Biochemistry

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“…Tropical trees of the Garcinia genus are mainly distributed in Southeast Asia, India, Africa, and Brazil, and many of them have medicinal and culinary uses Garcinia plants are an important source of polyphenols, including flavonoids, xanthones, and phloroglucinols. − In particular, caged xanthones with a partially dearomatized prenylated polyphenol core have attracted considerable attention owing to their complex carbon skeleton and potential antitumor activity . The most representative caged xanthone, gambogic acid, entered clinical trials to treat colon, non-small cell lung, and renal cancers in China .…”

mentioning

confidence: 99%

Structurally Diverse Cytotoxic Polyphenols from Garcinia gracilis

Ye,

Duan,

Zhou

et al. 2023

J. Nat. Prod.

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Thirty-five diverse polyphenols, belonging to seven structure classes, were isolated from Garcinia gracilis, a medicinal and edible plant sampled from Laos. The structures of nine new compounds, gargarcilones A−I (1−3, 5−7, 10, 12, and 17), were established using spectroscopic, X-ray diffraction, and experimental and calculated ECD methods. Additionally, we revised the stereochemical assignment of cochinchinoxanthone and cochinchinoxanthone C. The compounds were evaluated for antiproliferative activity against five human tumor cell lines (HL-60, A549, SMMC-7721, MDA-MB-231, and SW480). Compounds 1−4, 7, and 8 exhibited cytotoxic activity with IC 50 values of 0.5−8.9 μM. Compound 3 significantly induced apoptosis in SMMC-7721 cells.

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Optimization of Extraction Conditions for Biological Attributes of Newly Developed NARC‐G1 Garlic Using Response Surface Methodology and Its GC‐MS Characterization

Ullah,

Fayyaz ur Rehman

2024

Chemistry & Biodiversity

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The present paper is a comprehensive study on the optimization of ultrasonic assisted extraction and characterization of valued components from the newly developed garlic cultivar NARC‐G1. The response surface methodology was employed to optimize the extraction time, solvent‐to‐solid ratio and extraction temperature, for optimal total phenolic contents (TPC), DPPH radical scavenging activity, α‐amylase inhibition, and α‐glucosidase inhibition. Under the optimized conditions (23 min extraction time, 60 °C temperature, and 39 : 1 solvent‐to‐solute ratio) the optimal TPC (13.76 mg GAE/g), DPPH radical scavenging activity (62.76 %), α‐amylase inhibition (71.43 %), and α‐glucosidase inhibition (79.43 %) were obtained. Significant correlations were observed between actual values and predicted values for the selected responses. Gas chromatography‐mass spectrometry (GC‐MS), revealed 26 high‐value bioactives, with diallyl disulphide being the most abundant (16.22 %), followed by 2,3‐dihydro‐3,5‐dihydroxy‐6‐methyl, 4H‐pyran‐4‐one and 5‐Hydroxymethylfurfural. Additionally, in silico investigation indicated that stigmasterol, arbutin, squalene, α‐tocopherol and linoleic acid were responsible for antihyperglycemic potential. Moreover, antimicrobial activity revealed that S. mutans (19.25±1.98 mm) and L. monocytogenes (19.34±2.04 mm) were the most sensitive, while P. aeruginosa was the least sensitive bacterial strains against the optimized NARC‐G1 garlic extract. This research effectively explains the optimal recovery of high‐valued components from NARC‐G1 and may contribute to nutra‐pharmaceutical and functional food developments.

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Inhibitory Effects against Alpha-Amylase of an Enriched Polyphenol Extract from Pericarp of Mangosteen (Garcinia mangostana)

Cited by 7 publications

References 79 publications

Mechanistic Insights into the Xanthones Present in Mangosteen Fruit (Garcinia mangostana) and Their Applications in Diabetes and Related Complications

Mechanistic Insights into the Xanthones Present in Mangosteen Fruit (Garcinia mangostana) and Their Applications in Diabetes and Related Complications

Structurally Diverse Cytotoxic Polyphenols from Garcinia gracilis

Optimization of Extraction Conditions for Biological Attributes of Newly Developed NARC‐G1 Garlic Using Response Surface Methodology and Its GC‐MS Characterization

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