Antioxidant ameliorative effect of caffeic acid on the ectopic endometrial cells separated from patients with endometriosis

Jamali, Navid; Mostafavi‐Pour, Zohreh; Zal, Fatemeh; Kasraeian, Maryam; Poordast, Tahereh; Nejabat, Negar

doi:10.1016/j.tjog.2020.12.003

Cited by 15 publications

(13 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Although several options including vaccines, peptides, interferon therapies, and monoclonal antibodies could be developed to control or prevent emerging infections of COVID-19, it requires months to years for ultimate approval [5,10]. Interestingly, over 1800 years ago, traditional Chinese medicine was considered to be the mainstay of infectious diseases treatment [22], indeed, in addition to antiviral properties, this historical disease management strategy has been considered by researchers in recent years for managing and/or treating cancer, inflammatory and cardiovascular diseases, diabetes, infertility, and other pathological conditions [23][24][25]. Generally, phytochemicals, particularly polyphenols, possess antiviral activities against several viral components and actions [26].…”

Section: Discussionmentioning

confidence: 99%

Medicinal plant compounds as promising inhibitors of coronavirus (COVID-19) main protease: anin silicostudy

Jamali

Soureshjani

Mobini

et al. 2021

Journal of Biomolecular Structure and Dynamics

Self Cite

View full text Add to dashboard Cite

Background:The novel Coronavirus (COVID-19) has spread rapidly across the globe and has involved more than 213 countries and territories. Due to a lack of effective therapy or vaccine, urgent and concerted efforts are needed to identify therapeutic targets and medications. COVID-19 main protease represents a major target for drug treatment to inhibit viral function.Objectives: The present study sought to evaluate medicinal plant compounds as potential inhibitors of the COVID-19 main protease using molecular docking and molecular dynamic analysis. Methods:The PDB files of COVID-19 main protease and some medicinal plant compounds were retrieved from the Protein Data Bank (http://www.rcsb.org) and Pubchem server, respectively. The Gromacs software was used for simulation studies, and molecular docking analysis was done using Autodock 4.2. The COVID-19 main protease simulation, compared with some phytochemicals docked to the COVID-19 main protease, were analyzed.Results: Glabridin, catechin, and fisetin had the greatest tendency to interact with the COVID-19 main protease by hydrogen and hydrophobic bonds. Docking of these phytochemicals to COVID-19 main protease led to an increase in the radius of gyration (Rg), decrease in the Root mean square fluctuation (RMSF), and induced variation in COVID-19 main protease secondary structure. Conclusion:The high tendency interaction of glabridin, catechin, and fisetin to COVID-19 main protease induced conformational changes on this enzyme. These interactions can lead to enzyme inhibition. This simulated study indicates that these phytochemicals may be considered as potent inhibitors of the viral protease; however, more investigations are required to explore their potential medicinal use.

show abstract

Section: Discussionmentioning

confidence: 99%

Medicinal plant compounds as promising inhibitors of coronavirus (COVID-19) main protease: anin silicostudy

Jamali

Soureshjani

Mobini

et al. 2021

Journal of Biomolecular Structure and Dynamics

Self Cite

View full text Add to dashboard Cite

show abstract

“…EM implants in rat were significantly regressed 142,143 . Caffeic acid found in plants exerted similar antioxidant effects in EM and an enhanced nuclear translocation of nuclear factor erythroid 2–related factor 2 (Nrf2) regulated antioxidant enzymes in EM 141,261 …”

Section: Potential New Pharmaceuticals and Their Target‐signaling Pathwaysmentioning

confidence: 98%

Pharmaceuticals targeting signaling pathways of endometriosis as potential new medical treatment: A review

Hung

Zhang

Tan

et al. 2021

Medicinal Research Reviews

View full text Add to dashboard Cite

Endometriosis (EM) is defined as endometrial tissues found outside the uterus. Growth and development of endometriotic cells in ectopic sites can be promoted via multiple pathways, including MAPK/MEK/ERK, PI3K/Akt/mTOR, NF‐κB, Rho/ROCK, reactive oxidative stress, tumor necrosis factor, transforming growth factor‐β, Wnt/β‐catenin, vascular endothelial growth factor, estrogen, and cytokines. The underlying pathophysiological mechanisms include proliferation, apoptosis, autophagy, migration, invasion, fibrosis, angiogenesis, oxidative stress, inflammation, and immune escape. Current medical treatments for EM are mainly hormonal and symptomatic, and thus the development of new, effective, and safe pharmaceuticals targeting specific molecular and signaling pathways is needed. Here, we systematically reviewed the literature focused on pharmaceuticals that specifically target the molecular and signaling pathways involved in the pathophysiology of EM. Potential drug targets, their upstream and downstream molecules with key aberrant signaling, and the regulatory mechanisms promoting the growth and development of endometriotic cells and tissues were discussed. Hormonal pharmaceuticals, including melatonin, exerts proapoptotic via regulating matrix metallopeptidase activity while nonhormonal pharmaceutical sorafenib exerts antiproliferative effect via MAPK/ERK pathway and antiangiogenesis activity via VEGF/VEGFR pathway. N‐acetyl cysteine, curcumin, and ginsenoside exert antioxidant and anti‐inflammatory effects via radical scavenging activity. Natural products have high efficacy with minimal side effects; for example, resveratrol and epigallocatechin gallate have multiple targets and provide synergistic efficacy to resolve the complexity of the pathophysiology of EM, showing promising efficacy in treating EM. Although new medical treatments are currently being developed, more detailed pharmacological studies and large sample size clinical trials are needed to confirm the efficacy and safety of these treatments in the near future.

show abstract

“…The vasorelaxant activity and antiangiogenic effects of CA contribute to protecting against atherosclerosis. Additionally, it possesses immunomodulatory properties, antimicrobial activity against human pathogenic bacteria, protection against endometriosis progression, and neuroprotective effects as it reduces the oxidative stress and microglial activation in the hippocampus, preventing neurodegeneration in mice [ 101 , 102 , 103 , 104 , 105 , 106 ]. CA has been recently proposed as a potential modulator of oncogenic molecular pathways since it can induce apoptosis in cancer cells, take part in cell mechanisms associated with cancer progression in cancer therapy, sensitize cancer cells to chemotherapy, and suppress the proliferation of HeLa cells [ 107 , 108 ].…”

Section: Hydroxycinnamic Acidsmentioning

confidence: 99%

Chitosan–Hydroxycinnamic Acids Conjugates: Emerging Biomaterials with Rising Applications in Biomedicine

Ojeda-Hernández

Canales-Aguirre²,

Matías‐Guiu

et al. 2022

IJMS

View full text Add to dashboard Cite

Over the past thirty years, research has shown the huge potential of chitosan in biomedical applications such as drug delivery, tissue engineering and regeneration, cancer therapy, and antimicrobial treatments, among others. One of the major advantages of this interesting polysaccharide is its modifiability, which facilitates its use in tailor-made applications. In this way, the molecular structure of chitosan has been conjugated with multiple molecules to modify its mechanical, biological, or chemical properties. Here, we review the conjugation of chitosan with some bioactive molecules: hydroxycinnamic acids (HCAs); since these derivatives have been probed to enhance some of the biological effects of chitosan and to fine-tune its characteristics for its application in the biomedical field. First, the main characteristics of chitosan and HCAs are presented; then, the currently employed conjugation strategies between chitosan and HCAs are described; and, finally, the studied biomedical applications of these derivatives are discussed to present their limitations and advantages, which could lead to proximal therapeutic uses.

show abstract

Antioxidant ameliorative effect of caffeic acid on the ectopic endometrial cells separated from patients with endometriosis

Cited by 15 publications

References 29 publications

Medicinal plant compounds as promising inhibitors of coronavirus (COVID-19) main protease: anin silicostudy

Medicinal plant compounds as promising inhibitors of coronavirus (COVID-19) main protease: anin silicostudy

Pharmaceuticals targeting signaling pathways of endometriosis as potential new medical treatment: A review

Chitosan–Hydroxycinnamic Acids Conjugates: Emerging Biomaterials with Rising Applications in Biomedicine

Contact Info

Product

Resources

About