Antioxidant activity of the extracts from fruiting bodies of culturedCordyceps sinensis

Yamaguchi, Yu; Kagota, Satomi; Nakamura, Kazuki; Shinozuka, Kazumasa; Kunitomo, Masaru

doi:10.1002/1099-1573(200012)14:8<647::aid-ptr670>3.0.co;2-w

Cited by 125 publications

(77 citation statements)

References 9 publications

(7 reference statements)

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“…21,22,30,31 The ROS scavenging effect of CS extracts may be related to the effect on M1 mAChR because M1 mAChR is reported to determine cellular vulnerability to oxidative stress. 44 It is, however, also reported that ROS is involved in the regulation of M1 mAChR function as a second messenger.…”

Section: Discussionmentioning

confidence: 99%

“…In many studies it has been shown that CS possesses various biological activities that support human homeostasis such as antitumor, 19,20 antioxidant, 21,22 immunomodulatory, [23][24][25] hypoglycemic, 26,27 vasorelaxant activities, 28 and antidepressant activity. 29 A methanol extract from Cordyceps ophioglossoides, a similar parasitic mushroom, was reported to scavenge the reactive oxygen species (ROS) generated by Aβ peptides.…”

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confidence: 99%

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Effects of extracts from Cordyceps sinensis on M1 muscarinic acetylcholine receptor in vitro and in vivo

Chiba

Yamada²,

Torii³

et al. 2010

JRLCR

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Cholinergic dysfunction is implicated in the pathogenesis of memory impairment related to Alzheimer's disease (AD). Accordingly, regulation of M1 muscarinic acetylcholine receptor (M1 mAChR) has been one of the major targets in the development of novel drugs for AD. Utilizing an in vitro system for evaluation of the M1 mAChR, we have recently identified that extracts from Cordyceps sinensis (CS) promote M1 mAChR function. In this study, we examined the effect of pretreatment with several types of CS extracts in F11 neurohybrid cells on ERK phosphorylation induced by a muscarinic agonist, carbachol (CCh). A mixed extract of a hot water extract and an ethanol extract from CS augmented ERK phosphorylation by CCh presumably through upregulation of M1 mAChR function. We further examined the effect of oral administration of CS extracts on memory impairment induced by a muscarinic antagonist scopolamine in mice, finding that CS extracts ameliorated scopolamine-induced amnesia in vivo, consistent with the in vitro data. Thus CS extracts may contribute to the prevention of memory impairment related to AD.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Effects of extracts from Cordyceps sinensis on M1 muscarinic acetylcholine receptor in vitro and in vivo

Chiba

Yamada²,

Torii³

et al. 2010

JRLCR

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“…[7,8,12,14,15,24,39,48,52,66,67,83,92,98,107,121,136,140,161,162,167,173,177,178,180,188,194,200,207,208,[210][211][212]. [164].…”

Section: 배지 균사체 및 자실체 생산mentioning

confidence: 99%

Properties of the Silkworm (Bombyx mori) Dongchunghacho, a Newly Developed Korean Medicinal Insect-borne Mushroom: Mass-production and Pharmacological Actions

Lee¹,

Kim²,

Park³

et al. 2017

Journal of Life Science

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Cordyceps is a traditional Chinese medicinal herb well-known in China, Korea and Japan since B.C. 2,000. The original entomopathogenic fungus, Cordyceps sinensis belonging to the genus Cordyceps could not be found inside Korean peninsula due to the absence of the host insect for the corresponding entomogenous fungus. The development of artificial production methods of Korean type Cordyceps using the silkworm Bombyx mori as in vivo culture medium for the the entomopathogenic fungus Paecilomyces tenuipes is the first, and wonderful occasion in the research history of insect industry of this global world. The aim of this article is to review the historical research background, mass-production methods, and pharmacological effects of the silkworm-dongchunghacho (Paecilomyces tenuipes) which is a newly developed Korean medicinal insect-borne mushroom, and another non-insect-borne medicinal mushroom (Cordyceps militaris and Cordyceps pruinosa). Their biological actions include anti-tumor, immunostimulating, anti-fatigue, anti-stress, anti-oxidant, anti-aging, anti-diabetic, anti-inflammatory, anti-thrombosis, hypolipidaemic and insecticidal effects. The bioactive principles are protein-bound polysaccharides (hexose, hexosamin), cordycepin, D-manitol, acidic polysaccharide etc. Protein-bound polysaccharides and n-butanol fractions were demonstrated to show a significant anti-tumor activities but did not show a cytotoxicities. D-mannitol exhibited a significant prolongation of the life span in tumor bearing mice. Ergosterol did not show an efficient anti-tumor activity, but showed a significant phagocytosis enhancing activity. Anti-tumor activity of silkworm-dongchunghacho might be attributed to immuno-stimulating activities rather than cytotoxic effects [164]. Also this review comprises the breeding of Dongchunghacho varieties, optimization of culture conditions, improvement of learning and memory by Dongchunghacho, application of them as foods and chemical constituents.

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“…For the purpose of this study, we prepared a hot water extract of the fruiting bodies of cultured C. sinensis (WECS). WECS has demonstrated the ability to activate Kupffer cells in rats [1], anti-oxidant activity [2], and inhibitory effects on raised serum lipid peroxide levels and aortic cholesterol deposition in atherosclerotic mice [3]. WECS also produces an anti-tumor effect by stimulating adenosine A 3 receptors, followed by activation of glycogen synthase kinase (GSK)-3β in the Wnt signaling pathway [4].…”

Section: Introductionmentioning

confidence: 99%

Effect of Cordyceps sinensis on TIMP-1 secretion from mouse melanoma cell

et al. 2011

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Cordyceps sinensis is a Chinese medicinal fungus traditionally used in cancer treatments. In a previous study, we investigated the antimetastatic activity of Cordyceps sinensis (WECS) extract using liver metastatic model mice injected with B16-F0 mouse melanoma cells into the spleen. WECS reduced the number of metastatic nodules of B16-F0 cells in the liver of C57BL/6 mice, and significantly prolonged survival of the mice. Furthermore, we examined the effects of WECS on hepatocyte growth factor (HGF)-accelerated invasion of B16-F0 cells using a chemo-invasion assay in vitro. WECS was shown to significantly reduce HGF-accelerated B16-F0 cell invasion. In the present study, we investigated the effect of WECS on Tissue Inhibitor of Metalloproteinase (TIMP)-1 secretion from B16-F0 cells in order to identify clues to the mechanism underlying the anti-invasive action of WECS. As a result, WECS significantly increased the secretion of TIMP-1 from B16-F0 cells. Moreover, we investigated the effect of cordycepin (3′-deoxyadenosine), a component of WECS, on TIMP-1 secretion from B16-F0 cells to potentially identify the pharmacologically active ingredient in WECS extract. Cordycepin was shown to significantly accelerate the release of TIMP-1 from cells. These findings suggest that WECS exerts anti-invasive activity, in part by increasing TIMP-1 secretion from melanoma cells, and that cordycepin potentially functions as the effective component.

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Antioxidant activity of the extracts from fruiting bodies of culturedCordyceps sinensis

Cited by 125 publications

References 9 publications

Effects of extracts from Cordyceps sinensis on M1 muscarinic acetylcholine receptor in vitro and in vivo

Effects of extracts from Cordyceps sinensis on M1 muscarinic acetylcholine receptor in vitro and in vivo

Properties of the Silkworm (Bombyx mori) Dongchunghacho, a Newly Developed Korean Medicinal Insect-borne Mushroom: Mass-production and Pharmacological Actions

Effect of Cordyceps sinensis on TIMP-1 secretion from mouse melanoma cell

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