Antioxidant activity of prenylated flavonoids from the West African medicinal plant Dorstenia mannii

Dufall, Kitiya; Ngadjui, Bonaventure T.; Simeon, K.F.; Abegaz, Berhanu M.; Croft, Kevin D.

doi:10.1016/s0378-8741(03)00108-9

Cited by 33 publications

(28 citation statements)

References 24 publications

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“…(Fabaceae) possessed good anti-inflammatory activity as well as antioxidant activity by detecting 2,2 0 -azino-bis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS), 1,1-diphenyl-2-picrylhydrazyl (DPPH), peroxynitrite (ONOO(À)) and total reactive oxygen species (ROS) (Jung et al, 2008). More emerging evidences also demonstrated that the prenylflavonoids had strong radical scavenging properties toward the DPPH radical (Dufall et al, 2003;Jayasinghe et al, 2008;Kumazawa et al, 2007;Lee et al, 2006;Park et al, 2006).…”

Section: Antioxidant Activitymentioning

confidence: 99%

A systematic review on biological activities of prenylated flavonoids

Chen

Mukwaya

Wong

et al. 2013

Pharmaceutical Biology

190

136

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Context: Prenylated flavonoids are a unique class of naturally occurring flavonoids that exist especially for the plant's self-defensive strategy. This special class of flavonoids increases the bioactivities of their backbone flavonoids with non-prenylation; therefore, prenylated flavonoids have more potential to be developed and utilized. Objective: The number, position and type of the prenyl group on the flavonoids backbone structure may have close relationships with the bioactivities of flavonoids. Methods: PubMed and WEB OF KNOWLEDGEÕ were used to search articles published in English between 1 January 2002 and 31 December 2012, which discuss the structure-activity relationship between prenylated flavonoids and their bioactivities. Results: It is proposed that the prenyl-moiety makes the backbone compound more lipophilic, which leads to its high affinity with cell membranes. The prenylation brings the flavonoids with enhancement of antibacterial, anti-inflammatory, antioxidant, cytotoxicity, larvicidal as well as estrogenic activities. However, it is reported that the prenyl-moiety decreases the bioavailability and plasma absorption of prenylated flavonoids. Conclusion: The prenyl group affects the bioactivities of flavonoids in certain ways, while the action mechanisms and the structure-activity relationship as well as more in vivo studies even clinical validation trials need to be further investigated.

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Section: Antioxidant Activitymentioning

confidence: 99%

A systematic review on biological activities of prenylated flavonoids

Chen

Mukwaya

Wong

et al. 2013

Pharmaceutical Biology

190

136

View full text Add to dashboard Cite

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“…Species of the genus Dorstenia (Moraceae) are perennial, herbaceous plants that are widely distributed in tropical Africa, Middle-East, Central and South America (Abegaz et al, 1997;Dufall et al, 2003). In many parts of Africa, Dorstenia species are commonly used for the treatment and/or management of an array of human disorders, including: arthritis, rheumatism, gout, stomach disorders, cough, headache, skin diseases, and so forth (Bonquet, 1969;Abegaz et al, 1997;Dufall et al, 2003;Abegaz and Ngadjui, 1999).…”

Section: Introductionmentioning

confidence: 99%

Antinociceptive and anti-inflammatory effects of Dorstenia barteri (Moraceae) leaf and twig extracts in mice

Omisore

Adewunmi

Iwalewa

et al. 2004

Journal of Ethnopharmacology

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“…2,3) Species of the genus Dorstenia (Moraceae) are perennial, herbaceous plants that are widely distributed in tropical Africa, Asia, Middle-East, Central and South America. 4,5) Moraceae comprises a large family of sixty genera and nearly 1400 species, including important groups such as Artocarpus, Morus, and Ficus. The species of Morus have been shown to exhibit anti-HIV, anti-oxidative, anti-hypotensive, and cytotoxic activities.…”

mentioning

confidence: 99%

Inhibitory Effects of Morus alba on Compound 48/80-Induced Anaphylactic Reactions and Anti-Chicken Gamma Globulin IgE- Mediated Mast Cell Activation

Chai

Lee

Han

et al. 2005

Biological & Pharmaceutical Bulletin

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Mast cells are widely distributed throughout vascularized tissues and certain epithelia.1) Mast cells are responsible for a variety of allergic disorders including allergic rhinitis, dermatitis, asthma, and food allergies, as well as catastrophic anaphylactic reactions to insect stings and some drugs. These cells respond to IgE-directed antigens via the high-affinity receptor for IgE, Fce RI, by releasing granules that contain preformed inflammatory mediators and generating inflammatory lipids and cytokines. 2,3) Species of the genus Dorstenia (Moraceae) are perennial, herbaceous plants that are widely distributed in tropical Africa, Asia, Middle-East, Central and South America. 4,5) Moraceae comprises a large family of sixty genera and nearly 1400 species, including important groups such as Artocarpus, Morus, and Ficus. The species of Morus have been shown to exhibit anti-HIV, anti-oxidative, anti-hypotensive, and cytotoxic activities. [6][7][8] Plants of this genus are known to be rich in flavonoids, 9,10) a group of chemicals shown to have potent antiviral activities against herpes simplex virus, rhinovirus, human immunodeficiency virus, and various respiratory viruses. [11][12][13] This herb has been long used as an antiphlogistic, diuretic, and expectorant, 14) and also applied for control of inflammation, diabetes, and bronchial asthma. 15,16) The phenolic constituents and flavonoids of mulberry tree inhibits cAMP phosphodiesterase activity and regulates arachidonate metabolism in rat platelet homogenates. 17) Although studies have demonstrated that various effects of M. alba on numerous disease, the anti-allergic activity of the root bark of M. alba is poorly understood. Since calcium and cAMP have been shown to play a pivotal role in the mast cell activations, we have assessed the effect of the root bark of M. alba on calcium uptake and change of intracellular cAMP in mast cells. In this paper, we show that the root bark of M. alba inhibits the compound 48/80-induced systemic anaphylactic shock and anti-CGG IgE-induced rat peritoneal mast cell activations and the increased vascular permeability while cAMP level is increased. In addition, its effects are compared with disodium cromoglycate (DSCG), a known cell stabilizer which inhibits the release of pre-formed and newly synthesized chemical mediators from a variety of cells involved in allergic and inflammatory responses. 18) MATERIALS AND METHODS MaterialsCompound 48/80, bovine serum albumin (BSA), disodium cromoglycate (DSCG) and HEPES, chicken gamma globulin (CGG) were purchased from Sigma Chemical Co. (MO, U.S.A.). DSCG, an antianaphylactic agent, was used as positive control in order to compare with HEMA activity. Percoll solution was purchased from Pharmacia (Uppsala, Sweden). Anti-CGG IgE antibodies were supplied by Hern-Ku Lee works for department of immunology, Chonbuk National University Medical School.Experimental Animals Male ICR mice and SpragueDawley rats aged 8-10 weeks were purchased from Dae Han Experimental Animal Center (Daejeon, Korea...

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Antioxidant activity of prenylated flavonoids from the West African medicinal plant Dorstenia mannii

Cited by 33 publications

References 24 publications

A systematic review on biological activities of prenylated flavonoids

A systematic review on biological activities of prenylated flavonoids

Antinociceptive and anti-inflammatory effects of Dorstenia barteri (Moraceae) leaf and twig extracts in mice

Inhibitory Effects of Morus alba on Compound 48/80-Induced Anaphylactic Reactions and Anti-Chicken Gamma Globulin IgE- Mediated Mast Cell Activation

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