Antioxidant activity of novel quinazolinones bearing sulfonamide: Potential radiomodulatory effects on liver tissues via NF-κB/ PON1 pathway

Radiomodulatory effect of a non-electrophilic NQO1 inducer identified in a screen of new 6, 8-diiodoquinazolin-4(3H)-ones carrying a sulfonamide moiety

“…Hence, compound 15 validated its radiomodulatory and antioxidant effect through its main structure; quinazolinone and sulfonamide that goes in line with Soliman et al. [ 52 ]. Also, this finding was reinforced by Cuadrado and his colleagues, who emphasized the importance of therapeutic targeting for Nrf2 because of its resourceful cytoprotective roles against a plethora of diseases that are associated with oxidative stress [ 53 ].…”

Synthesis of some quinazolinones inspired from the natural alkaloid L-norephedrine as EGFR inhibitors and radiosensitizers

“…IR spectra (KBr discs) were recorded using FT-IR spectrophotometer (Perkin Elmer, USA). 1 H, 13 C NMR and 2D NMR experiments were scanned on an NMR spectrophotometer (Bruker AXS Inc., Switzerland), operating at 500 MHz for 1 H and 125.76 MHz for 13 C. Chemical shifts are expressed in d-values (ppm) relative to TMS as an internal standard, using DMSO-d 6 and CDCl 3 as solvents. EIMS were measured using Shimadzu-GC/MS.…”

“…The NH proton appeared as two broad singlets at 4.15, 4.40 each integrated for half proton diagnostic for the suggested tautomerisation in the structure. All the assignments of 1 H and 13 C NMR signals were performed based on DEPT 135 as well as 2D NMR experiments including COSY, HSQC and HMBC (see Supplementary data 2). (Table 2).…”

“…Quinazolines are fused heterocyclic ring systems known for their variable biological activity [12][13][14][15] . They are well known for their inhibitory activity towards various protein kinase enzymes and their anticancer activity 16 .…”

Synthesis and antibacterial activity of novel myricetin derivatives containing sulfonylpiperazine

“…Piperazine and its series of compounds are important products connecting the chemical industry and the pharmaceutical industry (Suleman et al 2020), widely used in medicine (Alina et al 2020), pesticides (Peng and Wang 2018) and other fields. As a kind of pharmacophore group with extensive biological activities in antibacterial (Nadia and Mona 2020), weeding (Chen et al 2018), anticancer (Štěpánková et al 2020), antioxidant (Soliman et al 2020) etc., sulfonamide group has shown excellent activity and great value in the field of medicine and pesticides. Therefore, the structure of sulfonylpiperazine is often used in new drug design and development (Xu et al 2015).…”