Antioxidant Activity of Glycosylated Vitamin P and Its Suppressive Effect on Oxidative Stress in Hyperlipidemic Mice

Glucosyl Hesperidin Lowers Serum Triglyceride Level in Hypertriglyceridemic Subjects through the Improvement of Very Low-Density Lipoprotein Metabolic Abnormality

“…In fact, Chiba et al, have reported that hesperetin conjugated with glucuronic acid is detected in the serum of mice fed G-hesperidin (50). Further more, we have observed that serum concentrations of hesperetin glucuronides in rats administered G-hesperi din are markedly higher than those in rats administered hesperidin (6). This observation implies that G-hesperi din is absorbed more efficiently than hesperidin due to its high water solubility.…”

“…Furthermore, we have found that the supplementa tion of G-hesperidin markedly lowers serum triglyceride (TG) in mice with hyperlipidemia induced by a high-fat diet (6). Such a TG-lowering effect has been also observed in humans; it has been confirmed that 6-wk administration of G-hesperidin preferentially lowers serum TG level in hypertriglyceridemic subjects and that this effect is dependent on the dose level and term of G-hesperidin administration (10).…”

“…Our recent studies have shown that G-hesperidin as well as hesperidin exhibits such physiological activities as decrease of serum lipid peroxide level in hyperlipidemic mice (6), antihypertensive effect on spontaneously hypertensive rats ( 7,8) and suppression of passive cuta neous anaphylaxis in rats (9). These findings indicate that G-hesperidin behaves as hesperidin in the body and results in the exhibition of physiological activities.…”

Effects of Glucosyl Hesperidin on Serum Lipids in Hyperlipidemic Subjects: Preferential Reduction in Elevated Serum Triglyceride Level

“…Moreover, it has been verified that this deriva tive releases hesperidin through hydrolysis by brush border a-glucosidases and results in the exhibition of physiological activities (17,18). We have also found that the supplementation of G-hesperidin significantly lowered serum TG in hyperlipidemic mice and that the lowering effect was probably due to hesperidin released in vivo (19). From these findings, G-hesperidin is con sidered to be available effectively as a hesperidin source.…”

Bioavailability of Glucosyl Hesperidin in Rats

“…G-Hesperidin has been reported to possess almost the same antioxidant properties as hesperidin in vitro. 6) Moreover, it has been confirmed that the biological activities of G-hesperidin are the same or more than those of hesperidin. [7][8][9] Nishizaki et al reported that G-hesperidin and hesperidin dose-dependently inhibited passive cutaneous anaphylaxis in rats, and that the effect of G-hesperidin was more continuous than that of hesperidin.…”