Antioxidant Activity of Essential Oils from Wedelia chinensis (Osbeck) in vitro and in vivo Lung Cancer Bearing C57BL/6 Mice

Manjamalai, A.; Grace, V. M. Berlin

doi:10.7314/apjcp.2012.13.7.3065

Cited by 49 publications

(37 citation statements)

References 14 publications

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“…Wedelia chinensis EO has high antioxidant potential which was evaluated in lung cancer cell line implanted in C57BL/6 mice [85]. Increase in the activity of antioxidant enzymes like CAT, SOD, and GPx along with increased level of glutathione was observed in the mice model, showing the preventive effect of these EOs even in the in vivo models [85]. A proposed overall mechanism by which EOs display anticancer activity is presented in Figure 2.…”

Section: Mechanism Of Action Of Eosmentioning

confidence: 99%

Essential Oils and Their Constituents as Anticancer Agents: A Mechanistic View

Gautam

Mantha

Mittal

2014

BioMed Research International

220

160

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Exploring natural plant products as an option to find new chemical entities as anticancer agents is one of the fastest growing areas of research. Recently, in the last decade, essential oils (EOs) have been under study for their use in cancer therapy and the present review is an attempt to collect and document the available studies indicating EOs and their constituents as anticancer agents. This review enlists nearly 130 studies of EOs from various plant species and their constituents that have been studied so far for their anticancer potential and these studies have been classified as in vitro and in vivo studies for EOs and their constituents. This review also highlights in-depth various mechanisms of action of different EOs and their constituents reported in the treatment strategies for different types of cancer. The current review indicates that EOs and their constituents act by multiple pathways and mechanisms involving apoptosis, cell cycle arrest, antimetastatic and antiangiogenic, increased levels of reactive oxygen and nitrogen species (ROS/RNS), DNA repair modulation, and others to demonstrate their antiproliferative activity in the cancer cell. The effect of EOs and their constituents on tumour suppressor proteins (p53 and Akt), transcription factors (NF-κB and AP-1), MAPK-pathway, and detoxification enzymes like SOD, catalase, glutathione peroxidase, and glutathione reductase has also been discussed.

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Section: Mechanism Of Action Of Eosmentioning

confidence: 99%

Essential Oils and Their Constituents as Anticancer Agents: A Mechanistic View

Gautam

Mantha

Mittal

2014

BioMed Research International

220

160

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“…Besides, several other compounds including common saponins and phytosterol derivatives were also reported in the species, but they appear to have a more limited distribution. Recently, several studies have demonstrated the exploration of pharmacological potential, such as analgesic [10], androgen-suppressing [11], anticancer [12, 13], antibacterial, anticonvulsant, antifungal [14], antioxidant [13], anti-inflammatory [10, 15], antiosteoprotic [16], antiulcerogenic, antistress [17], hepatoprotective [18], and sedative activities [19]. However, the investigation about the chemical constituents of W. chinensis is not sufficient compared to the other plants in the genus Wedelia .…”

Section: Introductionmentioning

confidence: 99%

α-Amylase and α-Glucosidase Inhibitory Activities of Chemical Constituents from Wedelia chinensis (Osbeck.) Merr. Leaves

Thao

Binh

Luyen

et al. 2018

Journal of Analytical Methods in Chemistry

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As part of an ongoing search for new natural products from medicinal plants to treat type 2 diabetes, two new compounds, a megastigmane sesquiterpenoid sulfonic acid (1) and a new cyclohexylethanoid derivative (2), and seven related known compounds (3–9) were isolated from the leaves of Wedelia chinensis (Osbeck.) Merr. The structures of the compounds were conducted via interpretation of their spectroscopic data (1D and 2D NMR, IR, and MS), and the absolute configurations of compound 1 were determined by the modified Mosher's method. The MeOH extract of W. chinensis was found to inhibit α-amylase and α-glucosidase inhibitory activities as well as by the compounds isolated from this extract. Furthermore, compound 7 showed the strongest effect with IC50 values of 112.8 ± 15.1 μg/mL (against α-amylase) and 785.9 ± 12.7 μg/mL (against α-glucosidase). Compounds 1, 8, and 9 showed moderate α-amylase and α-glucosidase inhibitory effects. Other compounds showed weak or did not show any effect on both enzymes. The results suggested that the antidiabetic properties from the leaves of W. chinensis are not simply a result of each isolated compound but are due to other components such as the accessibility of polyphenolic groups to α-amylase and α-glucosidase activities.

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“…21 SOD activity was determined indirectly by the method of NBT. 29 CAT activity was measured by colorimetric assay.…”

Section: Oxidative Stress Markersmentioning

confidence: 99%

“…EPR spectroscopy can be used to directly study free radicals in the blood and tissues 19,20 or in vitro antioxidant study of natural antioxidants. 21,22 Previously, we reported that the liver and kidneys appear to be the major organs of QD deposition after intravenous administration and that QDs can undergo degradation in vivo. 23,24 The liver and kidneys are the most important organs for obtaining an overall assessment of the immune response and antioxidant activity.…”

Section: Introductionmentioning

confidence: 99%

Dose and time effect of CdTe quantum dots on antioxidant capacities of the liver and kidneys in mice

Wang

Sun

Meng

et al. 2017

IJN

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Although quantum dot (QD)-induced toxicity occurs due to free radicals, generation of oxidative stress mediated by reactive oxygen species (ROS) formation is considered an important mechanism. However, free radical mechanisms are essentially difficult to elucidate at the molecular level because most biologically relevant free radicals are highly reactive and short-lived, making them difficult to directly detect, especially in vivo. Antioxidants play an important role in preventing or, in most cases, limiting the damage caused by ROS. Healthy people and animals possess many endogenous antioxidative substances that scavenge free radicals in vivo to maintain the redox balance and genome integrity. The antioxidant capacity of an organism is highly important but seldom studied. In this study, the dose and time effects of CdTe QDs on the antioxidant capacities of the liver and kidneys were investigated in mice using the electron paramagnetic resonance (EPR) spin-trapping technique. We found that the liver and kidneys of healthy mice contain specific antioxidant capacities that scavenge ·OH and ·O 2 − . Furthermore, oxidative stress markers (superoxide dismutase [SOD], catalase [CAT], glutathione peroxidase [GPx], glutathione [GSH] and malondialdehyde [MDA]) were examined. In dose course studies, the free radical scavenging efficiencies of the liver and kidneys were found to gradually decrease with increasing concentration of CdTe QD exposure. The activities and levels of SOD, CAT, GPx and MDA were observed to increase in treated groups, whereas those of GSH were reduced. The time course studies revealed that the QD-induced antioxidant efficiency reduction was time dependent with GSH decrease and could recover after a period of time. These experimental results offer new information on QD toxicity in vivo. Specifically, CdTe QDs can deplete GSH to reduce the elimination ability of the liver and kidneys for ·OH and ·O 2 − , thus inducing oxidative damage to tissues.

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Antioxidant Activity of Essential Oils from Wedelia chinensis (Osbeck) in vitro and in vivo Lung Cancer Bearing C57BL/6 Mice

Cited by 49 publications

References 14 publications

Essential Oils and Their Constituents as Anticancer Agents: A Mechanistic View

Essential Oils and Their Constituents as Anticancer Agents: A Mechanistic View

α-Amylase and α-Glucosidase Inhibitory Activities of Chemical Constituents from Wedelia chinensis (Osbeck.) Merr. Leaves

Dose and time effect of CdTe quantum dots on antioxidant capacities of the liver and kidneys in mice

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