Antioxidant Activity of Coated Probiotic Lactobacillus casei on Chromium(VI) Induced Oxidative Stress in Rats

Lactobacillus rhamnosus ARJD as a Functional Food with Potential Antioxidant and Antibacterial Abilities

“…Simultaneously the feces of rats were collected from time to time on day 0, 3, 6, 9 and 12 in order to enumerate the total LAB count using MRS media and count of Enterobacteria in MacConkey agar. Haematological studies with other vital organ analysis were carried out to determine the aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP) [8,25]. The liver weight ratio and spleen weight index along with the percentage growth rate difference among both groups were evaluated and a significant difference among them was determined.…”

“…Many antioxidant scavenging assays by using Lactobacillus was demonstrated by a mechanism such as a hydroxyl radical and superoxide anions [7]. Lactobacillus is found with strong antioxidant abilities by neutralizing the free reactive oxygen radicals by various in-vitro studies [8]. It was also found that daily consumption of Lactobacillus yogurt improves the level of the plasma folate and vitamin B-12, with the enhancement of antioxidant properties which was demonstrated successfully in women with menopause conditions [9].…”

Chromium(VI) bioremediation by probiotics

“…The co‐administration of oral probiotic Lb. casei strain 17 reversed the changes introduced by Cr(VI) …”

“…casei strain 17 reversed the changes introduced by Cr(VI). 86 Oral intake of increasing doses of potassium dichromate over 90 days (0, 0.12, 0.24 and 0.36 g kg −1 diet) produced a decrease in performance and alteration in the lipidic, glycaemic, renal and hepatic profiles. The inclusion of 0.2% of probiotic (Lactobacillus acidophilus, 2.22 × 10 9 colony-forming units (CFU); Streptococcus faecium, 2.22 × 10 9 CFU; Bifidobacterium thermophilum, 2.22 × 10 9 CFU; Bifidobacterium longum, 2.22 × 10 9 CFU) in the diet significantly mitigated the toxic effect on the parameters mentioned above as well as the histopathological effects 87 (Younan S, unpublished; Parra MCG, unpublished).…”

“…Results obtained by Balakrishnan et al on Cr(VI) in the form of potassium dichromate that was administered subcutaneously showed that it caused significant changes in liver and kidney functional enzyme markers in the serum, namely total protein, alanine transaminase, urea and creatinine. Prominent histopathological changes were observed in the form of liver vascular congestion, degenerative changes, the dilation of the sinusoids and the infiltration of mononuclear cells to show the degeneration of kidney tubular epithelial cells, and the cystic dilation of tubules and hyaline.…”