Antioxidant activity of anthraquinones and anthrone

Yen, Gow‐Chin; Duh, Pin-Der; Chuang, Da-Yon

doi:10.1016/s0308-8146(00)00108-4

Cited by 347 publications

(245 citation statements)

References 18 publications

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“…This result is consistent with the distribution of anthraquinones in the different extracts (r 2 = 0.888). This correlation is supported by the existence of some anthraquinone compounds, possibly alizarin and emodin, which have an inhibitory activity on lipid peroxidation and reduce H 2 O 2 in cells [32,33]. In contrast to reference antioxidants used, hexane and dichloromethane extracts exhibited far higher activity than Trolox and BHT, at an average of 8-fold more active.…”

Section: In Vitro Antioxidant Activitymentioning

confidence: 88%

Free radical-scavenging activity of sequential leaf extracts of Embothrium coccineum

et al. 2015

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The aim of this study was to evaluate the influence of phenolic, flavonoid, and anthraquinones from sequential extracts (n-hexane, dichloromethane, ethyl acetate, and ethanol) of Embothrium coccineum leaves on the antioxidant capacity, cell viability, and toxicity of the same, in order to find possible sources for novel antioxidants for food and pharmaceutical formulations. Antioxidant potential of sequential extracts was analyzed by five different assays: 2,2-diphenyl-1- picrylhydrazyl radical scavenging activity assay (DPPH), hydrogen peroxide scavenging activity (H2O2), oxygen radical absorbance capacity (ORAC), ferric reducing antioxidant power (FRAP), and total reactive antioxidant potential (TRAP). An in vitro growth inhibition assay was performed using sulphorhodamine dye to quantify cell viability, while an in vivo brine shrimp lethality test was used to quantify toxicity. The dichloromethane extract has a greater efficiency in scavenging free radicals, combined with low toxicity, and no effect exhibited on healthy cells, compared to observations for the other extracts tested. Further research is in progress to identify and separate the active compounds of active extracts and investigate the protective effect of extracts on human dermal fibroblast injury induced by hydrogen peroxide.

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Section: In Vitro Antioxidant Activitymentioning

confidence: 88%

Free radical-scavenging activity of sequential leaf extracts of Embothrium coccineum

et al. 2015

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“…Reducing power is an indicator of electron donating activity, which is an important mechanism for testing antioxidant activity of plant extracts. Good correlation has been established between antioxidant capacity and reducing power (Yildirim et al 2001, Yen et al 2000 In-vivo studies Three doses i.e., 50, 100, and 200 mg (Tannic acid equivalent)/kg body weight were selected for the studies and the cell-free supernatant of liver (as described in materials and methods section), was used for the estimation of lipid peroxidation, peroxidase, catalase, and superoxide dismutase (SOD) activities.…”

Section: Reducing Power Assaymentioning

confidence: 99%

Antioxidant activities of tamarind (Tamarindus Indica) seed coat extracts using in vitro and in vivo models

2014

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Tamarindus indica seed coat was extracted with methanol, acetone and water and screened for DPPH radical scavenging activities. Methanol extract showed higher activity than other extracts. Treatment of albino rats (Wistar strain) with CCl 4 at 1.25 mL/kg of body weight decreased superoxide dismutase (55 %), catalase (73 %) and peroxidase (78 %), while lipid peroxidation increased nearly 2.5 fold in liver. Pretreatment of rats with methanol extract of T. Indica seed coat (TSCE) at 50 mg/kg (as tannic acid equivalents) followed by CCl 4 treatment, caused restoration of superoxide dismutase, catalase and lipid peroxidation to values close to control while peroxidase was restored to 67 % of the control. Histopathological studies of liver of different groups supported the protective effects of TSCE by restoring the hepatic architecture. These studies could be further extended to exploit its possible application for the preservation of food products as well as a health supplement and neutraceutical.

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“…Rhein and chrysophanol are known to be present in the roots [2], in addition to two other quinone pigments [18]. These anthraquinone derivatives are well known to exhibit a variety of biological activities [19], such as antimicrobial [2], antifungal [20], antitumor [21], antioxidant [22], cytotoxic [23], and hypoglycemic [24] activities. The flavonoid kaempferol has been reported to have anticancer properties [25,26].…”

Section: Published In Final Edited Form Asmentioning

confidence: 99%

Determination of pharmacologically active compounds in root extracts of Cassia alata L. by use of high performance liquid chromatography

Fernand

Dinh

Washington

et al. 2008

Talanta

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A simple high performance liquid chromatography (HPLC) method was developed and validated for the determination of six phenolic compounds, five anthraquinones (rhein, aloe-emodin, emodin, chrysophanol and physcion) and a flavonoid (kaempferol), in root extracts from Cassia alata L. Solid-phase extraction, using C 18 cartridges, was used to remove interfering substances from the root extracts. The extracts were analyzed on a C 18 column using an isocratic mobile phase which consisted of acetonitrile, methanol, and 10 mM aqueous ammonium acetate (25: 55: 20, v/v). Identification of the analytes was performed by use of standards and on-line mass spectrometric detection using atmospheric pressure chemical ionization. The concentration of the phenolic compounds in the root extracts was determined using HPLC with ultraviolet detection at 260 nm. The limits of detection obtained for the anlytes were in the range of 0.23 -4.61 ppm. The overall R.S.D. precision values (intra and inter-day) for the retention times and peak-areas were lower than 0.16% and 2.10%, respectively. In addition, the recovery of the developed method for the analysis of these phenolic compounds was determined, and ranged from 81.2 ± 4.3% to 106 ± 2%.

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Antioxidant activity of anthraquinones and anthrone

Cited by 347 publications

References 18 publications

Free radical-scavenging activity of sequential leaf extracts of Embothrium coccineum

Free radical-scavenging activity of sequential leaf extracts of Embothrium coccineum

Antioxidant activities of tamarind (Tamarindus Indica) seed coat extracts using in vitro and in vivo models

Determination of pharmacologically active compounds in root extracts of Cassia alata L. by use of high performance liquid chromatography

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