Antioxidant activity coefficient, mechanism, and kinetics of different derivatives of flavones and flavanones towards superoxide radical

Ahmed, Safeer; Shakeel, Faria

doi:10.17221/447/2010-cjfs

Cited by 43 publications

(42 citation statements)

References 31 publications

(29 reference statements)

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“…Such changes suggested that phenolic sulfur-containing compounds, in reaction to the superoxide anion radical, acted as proton donors (that is, Brønsted acids), which was in good agreement with the literature data [26,27].…”

Section: As Shown Insupporting

confidence: 90%

In silico and in vitro evaluation of the biological activity of some organicsulfur-containing compounds

Осипова¹,

Половинкина²,

Osipova³

et al. 2019

Turk J Chem

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generation rate decreased in the presence of the studied compounds, evidencing for their antiradical activity.Increase of superoxide dismutation activity of the biopreparation in the presence of compounds 1-10 was also shown, and this fact could indicate their ability to increase the antioxidant status and decrease the probability of oxidative stress development. It was found that compounds 1-10 did not inhibit enzyme lipoxygenase, which indicated the absence of antiinflammatory activity. The results of the forecast were consistent with the data of the experimental studies.

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Section: As Shown Insupporting

confidence: 90%

In silico and in vitro evaluation of the biological activity of some organicsulfur-containing compounds

Осипова¹,

Половинкина²,

Osipova³

et al. 2019

Turk J Chem

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show abstract

“…as well as singlet oxygen ( 1 O 2 − ) . Over produced ROS generates oxidative stress which can be reduced through antioxidant . Antioxidants can not only scavenge the ROS in body but can also regulate ROS related enzymes such as radical generating NAD(P)H oxidase and xanthine oxidase (XO) or radical reducing superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX) .…”

Section: Introductionmentioning

confidence: 99%

Antioxidant Activity and Hepatotoxicity of Flavonoids and Their Metal Complexes Through Co‐Administration of β‐Cyclodextrin

et al. 2019

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The in vivo determination of radical scavenging activity of flavonoids (Fls) and their metal complexes (M‐Fls) through co‐administration of 2‐hydroxypropyl beta‐cyclodextrin (HP‐βCD) was determined. The flavonoids morin (mo), quercetin (quer), primuletin (prim), their Cu (II) and Fe (III) complexes were selected to explore their radical scavenging potential. Metal complexes of flavonoids (M‐Fls) showed better radical scavenging activity RSA when injected to rats than corresponding flavonoids. The RSA is improved in the presence of HP‐βCD. This increase in RSA was assisted by enhanced enzymatic activity of catalase (CAT) and superoxide dismutase (SOD) activity. The compounds displayed hepatoprotection against alloxan induced liver damage as flavonoid injected group displayed lower levels of enzymes and intermediates aspartate/alanine transaminase (AST), alanine aminotransferase (ALT), Lipid peroxidation (MDA), Hydroxyproline (HYP), Sailic acid (SA) and higher albumin and total proteins level compared with alloxan treated group. It was evaluated by histopathological investigations that M‐Fls restored the hepatic damage caused by alloxan. The binding constants values of the compounds with human plasma (n‐HP) revealed the order of 103‐104 L−1. The binding interactions of the compounds with human plasma in the presence of HP‐βCD is decreased which in turns increased the RSA as well as CAT and SOD activities. Based upon our results, it was concluded that radical scavenging activities and hepatoprotective activities of M‐Fls is increased when co‐administrated with HP‐βCD.

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“…This underestimation, comparing to the DPPH result, was probably due to the low ratio of phenolic acids and flavonoids detected at 750 mV in PP extract which is composed mainly of ellagitannins, macromolecules of tannins. These high molecular weight antioxidants (HMWA) are, possibly, not suitable to CV assay than the low molecular weight antioxidants (LMWA) because of high weight (Ahmed & Shakeel, ) (Chevion, Roberts, & Chevion, ). Moreover, Arteaga et al () reported that only antioxidant DPPH assay of LMWA could be correlated with antioxidant CV assay.…”

Section: Resultsmentioning

confidence: 99%

Improvement of microwave‐assisted Soxhlet extraction of bioactive compounds applied to pomegranate peels

Oualcadi

Sebban²,

Berrekhis

2020

J Food Process Preserv

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A novel Microwave‐Assisted Soxhlet Extraction (MASE) was performed to upgrade the classic Soxhlet extraction of polyphenols from pomegranate peels, one of the most studied by‐products. The response surface methodology (RSM) modeling was used for the estimation of predictive total polyphenols content (TPC), total flavonoid content (TFC), and total tannin content (TTC). Maximum compounds of the three output parameters: 376 mg gallic acid equivalents (GAE)/g dry weight (dw) TPC yield, 163 mg rutin equivalents/g dw TFC yield, and 323 mg GAE/g dw TTC yield, were obtained under optimum extraction conditions. In addition, the extract had a high antioxidant capacity of 533g ascorbic acid equivalent/g dw using 2,2‐diphenyl‐1‐picrylhydrazyl assay. The major phenolic compounds, especially punicalagin, were identified by ultra‐high‐performance liquid chromatography followed by the electrospray ionization coupled with mass spectrometry (UHPLC/ESI/MS). The proposed method (MASE) permitted to develop a fast solvent‐minimized extraction process and improve the quantity of extracts obtained from a natural resource. Practical applications The valorization of natural by‐products involves the optimization and improvement of extraction techniques. MASE is a coupling of two conventional extractions that could be used in industry to improve yields, while reducing the time and cost of extracting target bioactive compounds. With this coupling, it is possible to modify or add other factors to target a well‐defined molecule in order to obtain the richest extract in these target molecules.

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Antioxidant activity coefficient, mechanism, and kinetics of different derivatives of flavones and flavanones towards superoxide radical

Cited by 43 publications

References 31 publications

In silico and in vitro evaluation of the biological activity of some organicsulfur-containing compounds

In silico and in vitro evaluation of the biological activity of some organicsulfur-containing compounds

Antioxidant Activity and Hepatotoxicity of Flavonoids and Their Metal Complexes Through Co‐Administration of β‐Cyclodextrin

Improvement of microwave‐assisted Soxhlet extraction of bioactive compounds applied to pomegranate peels

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