Antioxidant activity assays on-line with liquid chromatography

Niederländer, H.A.G.; Beek, T.A. van; Bartasiute, Aiste; Koleva, Irina

doi:10.1016/j.chroma.2008.09.061

Cited by 170 publications

(121 citation statements)

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“…A typical example developed in our group is online radical scavenging detection (Dapkevicius et al 1999;Koleva et al 2000;Koleva et al 2001;Dapkevicius et al 2001;Niederländer et al 2008). Phenolic antioxidants can terminate radical chain processes in lipid rich foods by reacting with reactive oxygen species (ROS) forming more stable resonance-stabilised radicals or quinone-like structures (Fig.…”

Section: High-resolution Screeningmentioning

confidence: 99%

Recent developments in the rapid analysis of plants and tracking their bioactive constituents

et al. 2009

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Section: High-resolution Screeningmentioning

confidence: 99%

Recent developments in the rapid analysis of plants and tracking their bioactive constituents

et al. 2009

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“…In this case, the sample undergoes separation only on one column; however, the separated compounds are derivatized postcolumn to check their possible antioxidant potential [14]. There are three main categories of antioxidant activity assays, namely, (1) tests that use true reactive oxygen species, (2) assays involving a relatively stable single oxidizing regents, and (3) methods applying electrochemical detection.…”

Section: Biological Fingerprinting By Means Of Hplcmentioning

confidence: 99%

Biological Fingerprinting of Herbal Samples by Means of Liquid Chromatography

Cieśla

2012

Chromatography Research International

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Biological chromatographic fingerprinting is a relatively new concept in the quality control of herbal samples. Originally it has been developed with the application of HPLC, and recently herbal samples' biological profiles have been obtained by means of thin-layer chromatography (TLC). This paper summarizes the application of liquid chromatographic techniques for the purpose of biological fingerprint analysis (BFA) of complex herbal samples. In case of biological TLC fingerprint, which is a relatively novel solution, perspectives of its further development are outlined in more detail. Apart from already published data, some novel results are also shown and briefly discussed. The paper aims at drawing scientists' attention to the unique solutions offered by biological fingerprint construction.

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“…Because the reactive oxygen species (ROS) were found as responsible for numerous human diseases (e.g., atherosclerosis, Alzheimer's disease, inflammation, asthma, rheumatoid arthritis, etc. ), antioxidants and free radical scavengers are currently the subject of an intensive research interest [10].…”

Section: Introductionmentioning

confidence: 99%

Specific mobility of selected phytochemicals in thin-layer chromatographic systems and its possible relevance to pharmacokinetics

Knaś

Szeremeta

Polański

et al. 2013

Acta Chromatographica

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Summary. In many publications on the thin-layer chromatographic analysis of the medicinal plant extracts, striking skewness of the separated chromatographic bands with many phytochemicals can be seen, although no attention has ever been paid to this odd mass transfer effect. In our earlier studies on the thin-layer chromatographic enantioseparation of certain low molecular weight carboxylic acids, lateral relocation thereof (i.e., the side-wise deviation of their migration route from linearity) was registered. Then we found out that lateral relocation was observed with these analytes only, which structurally resembled molecular rotors. In this study, we investigate the role played by the thin-layer chromatographic stationary phases in lateral relocation of botanically relevant molecular rotors. Thus, three carboxylic acids were selected as the test analytes, all of them resembling molecular rotors and abundantly present in the medicinal plant extracts. We selected two most popular thin-layer chromatographic stationary phases also, i.e., silica gel (characterizing with microcrystalline chirality) and alumina (achiral). Lateral relocation of the test analytes was observed on the silica gel stationary phase only. A conclusion was drawn that the chiral stationary phase makes a complementary contribution to lateral relocation (along with the propeller-like molecular structure of the analytes). In our view, specially devised thin-layer chromatographic systems can prove a convenient nano-platform for future investigation of the drug transport patterns, advantageous in the pharmacokinetic studies.

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Antioxidant activity assays on-line with liquid chromatography

Cited by 170 publications

References 100 publications

Recent developments in the rapid analysis of plants and tracking their bioactive constituents

Recent developments in the rapid analysis of plants and tracking their bioactive constituents

Biological Fingerprinting of Herbal Samples by Means of Liquid Chromatography

Specific mobility of selected phytochemicals in thin-layer chromatographic systems and its possible relevance to pharmacokinetics

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