Antioxidant activity and α-glucosidase inhibitability of Distichochlamys citrea M.F. Newman rhizome fractionated extracts: in vitro and in silico screenings

Abstract

Distichochlamys citrea M.F. Newman (commonly known as “Black Ginger”) is an endemic plant to Vietnam and has been extensively exploited by folk medication for treatments of infection-related diseases and diabetes. In this work, its rhizomes were subjected to fractionated extraction, phytochemical examination, evaluation of antioxidant effect by DDPH free radical neutralization, and inhibitory activity toward α -glucosidase. The compositional components were subjected to in silico screening, including density functional theory calculation, molecular docking simulation, physicochemical analysis, and pharmacokinetic regression. In the trials, EtOAc fraction is found as the bioactive part of most effectiveness, regarding both antioxidant effect (IC 50 = 90.27 µg mL −1 ) and α -glucosidase inhibitory activity (IC 50 = 115.75 μg mL −1 ). Chemical determination reveals there are 13 components of its composition. DFT-based calculations find no abnormal constraints in their structures. Docking-based simulation provides order of inhibitory effectiveness: 3-P53341 > 12-P53341 > 7-P53341 > 4-P53341 > 11-P53341 > 10-P53341 . QSARIS-based investigations implicate their biocompatibility. ADMET-based regressions indicate that all candidates are generally safe for medicinal applications. The findings would contribute to the basis for further studies on the chemical compositions of Distichochlamys citrea and their biological activities. Supplementary Information The online version contains supplementary material available at 10.1007/s11696-022-02273-2.

Phytochemical Constituents Isolated From Distichochlamys citrea M.F. Newman Rhizomes and Their Antioxidant and α-glucosidase Inhibitory Activities

“…A voucher specimen (DC-10.19) has been stored at the Laboratory of the Traditional Medicine, University of Medicine and Pharmacy at Ho Chi Minh City, Vietnam. 5,53…”

“…Newman rhizomes was carried out. 5 The plant D. citrea is native to the central region of Vietnam, where it was discovered in Thua Thien Hue, Quang Binh, Quang Tri, Quang Nam, and Nghe An Provinces. [6][7][8] Up to now, the investigations of chemical profiles and the biological activities of D. citrea have been limited.…”

“…In addition, recent studies on this plant are scarcely available despite raising scientific interest in the genus Distichochlamys , except for reports on compositions and biological activities of the essential oils such as anti-inflammation and anticancer, 9,10 and our previous study on the corresponding subject which reported that the ethyl acetate (EtOAc) fraction apparently exhibited both α -glucosidase inhibitory effect (IC 50 = 115.75 µg/mL) and antioxidant potential via 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging capacity (IC 50 = 90.27 µg/mL). 5 This study was carried out to isolate and determine the corresponding bioactivities of phyto-constituents from potential fractions of D. citrea . The present study reports the isolation, α -glucosidase inhibitory activities, and DPPH scavenging capacities of 7 compounds from D. citrea rhizomes.…”

Morphological characters, pharmacognostical parameters, and preliminary phytochemical screening of Curcuma sahuynhensis Škorni?k. & N.S.Lý in Quang Ngai Province, Vietnam

“…Furthermore, the highlight of this work is the first time that the phytochemical and experimental criteria of C. sahuynhensis have been reported in the literature. In extended studies, the majority of compounds (flavonoids, coumarins, tannins, alkaloids, and essential oils) were reported to display potent biological importance, as well as have positive effects on disease treatments such as antibacterial, antioxidant, anti-inflammatory, anti-allergic, anti-diabetic, anti-tumor, anti-cancer and other biological activities (Bouchelaghem et al 2022;Xiao 2022;Gulcin et al 2022;Van Chen et al 2022b)…”

Essential Oils ofDistichochlamys benenica: Chemical Constituents, Mosquito Larvicidal and Antimicrobial Activities

“…25 Several recent studies have focused on the phytochemical composition and bioactive properties of Distichochlamys species. [28][29][30][31] Additionally, investigations have been conducted into the chemical composition and biological activity of EOs derived from the leaves and rhizomes of D. citrea, D. orlowii, and D. benenica. [32][33][34][35][36][37] Notably, a study by Hoang et al 32 demonstrated the acetylcholinesterase activity of D. benenica rhizome EO collected from Quang Nam, Vietnam.…”