Antioxidant activity and protective role on protein glycation of synthetic aminocoumarins

Aminjafari, Akram; Miroliaei, Mehran; Angelova, Violina T.; Emamzadeh, Rahman; Djukić, Mirjana; Djurić, Ana; Saso, Luciano

doi:10.1016/j.ejbt.2016.08.004

Cited by 27 publications

(15 citation statements)

References 27 publications

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“…that the antioxidant activity of the colorant was lower than that for the standard (Table 3). This result was relevant to the studies of Aminjafari et al (2016) and Fernandes et al (2016). They addressed that the antioxidant activity of samples detected by DPPH assay was less than the standard because of a stronger radical scavenging property for ascorbic acid compared to the extract.…”

Section: Heavy Metal Contaminationsupporting

confidence: 71%

Production of colorant powder from dragon fruit ( Hylocerecus polyrhizus ) peel: Bioactivity, heavy metal contamination, antimutagenicity, and antioxidation aspects

Thaiudom

Oonsivilai

Thaiwong

2020

J Food Process Preserv

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This study explores the bioactivity, heavy metal contamination, antimutagenicity, and antioxidation aspects of a colorant powder (CP) derived from dragon fruit peels (DGFP) following a two‐step process: extraction and creation of colorant powder. Extraction with deionized water at pH 5.5, 40°C for 20 min provided betacyanin content in the crude extract at 15.21 ± 0.04 mg/g dry weight with betanin and phyllocactin as the main bioactive components. The extract antimutagenicity was found to be 0.522 mg GAE/mL. The extract was mixed with 6% maltodextrin and dried to produce CP using a spray dryer with a feed rate of 6 ml/min and a 160°C inlet temperature. The powder was red and no heavy metal was detected using ICP‐OES. The CP was proven to possess antioxidant activity as confirmed by DPPH, ABTS+, and FRAP assay. Thus, DGFPs should be recognized as a valuable by‐product with added value as a food colorant. Practical applications The crude extract from the dragon fruit peels contained betacyanin at 15.21 ± 0.04 mg/g dry weight. The extract possessing betanin and phyllocactin as the main bioactive compounds was found to be mutagenic safe. After the extract was spray‐dried with 6% maltodextrin to produce the colorant powder, the betacyanin content was reduced around twofold from the original content. However, the antioxidant activity still existed in the powder with no heavy metal contamination. Thus, the dragon fruit peels have a high potential for practical application as a safe food colorant.

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Section: Heavy Metal Contaminationsupporting

confidence: 71%

Production of colorant powder from dragon fruit ( Hylocerecus polyrhizus ) peel: Bioactivity, heavy metal contamination, antimutagenicity, and antioxidation aspects

Thaiudom

Oonsivilai

Thaiwong

2020

J Food Process Preserv

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“…One of the main reasons for this result is the fact that these methods are based on different reaction mechanisms. The DPPH assay is based on a hydrogen radical donating to a certain substance, the TRP assay is based on electron transfer between the substrate and tested sample, while the β-carotene bleaching assay is based on spearing the already present antioxidant [ 26 ]. These results clearly demonstrate the significance of applying more than one analytical method when assessing the antioxidant activity of some new extracts.…”

Section: Discussionmentioning

confidence: 99%

Extracts Characterization and In Vitro Evaluation of Potential Immunomodulatory Activities of the Moss Hypnum cupressiforme Hedw.

et al. 2020

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Recently, there has been an increasing interest in the chemistry and biological potential of mosses, since a large number of biologically active compounds have been found within these species. This study aimed at examining the chemical composition and immunomodulatory potential (antioxidant, antidiabetic, anti-neuroinflammatory/antineurodegenerative, and antitumor activities) of moss Hypnum cupressiforme Hedw. extracts. Corresponding extracts have been obtained applying Soxhlet extractor. The chemical characterization was performed using spectrophotometric assays and liquid chromatography–mass spectrometry (LC-MS). The extracts were analyzed for antioxidant activity and for inhibitory activities on α-glucosidase, α-amylase, acetylcholinesterase, and tyrosinase. Additionally, extracts were tested against four cell lines—MRC-5, BV2, HCT-116, and MDA-MB-231—for antitumor and anti-inflammatory activities. Chemical analysis of extracts revealed the presence of flavonoids, phenolic acids, and triterpenoids. Major compounds identified by LC-MS in H. cupressiforme were kaempferol and five phenolic acids: p-hydroxybenzoic, protocatechuic, p-coumaric, gallic, and caffeic acid. According to biochemical assays the investigated extracts exhibited significant immunomodulatory potential. Significant antiproliferative potential against MDA-MB-231 cells has been observed together with the promising anti-neuroinflammatory application. The obtained data suggest that moss H. cupressiforme is a valuable natural source of biologically active compounds with potential application in the pharmaceutical industry.

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“…Quantitative phytochemical analysis of extract was performed to estimate the primary and secondary metabolites [14]. In vitro antioxidant potential of extract was evaluated by 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging and reducing power assay following methods described previously [15]. The identification of metabolites was carried out by the means of a high-performance liquid chromatography (HPLC) system LC-10A (Shimadzu, Nagoya, Japan) using Shim-Pack CLC-ODS C—18 column (25 cm × 4.6 mm, 5 µm) [16].…”

Section: Methodsmentioning

confidence: 99%

Experimental and Computational Studies to Characterize and Evaluate the Therapeutic Effect of Albizia lebbeck (L.) Seeds in Alzheimer’s Disease

et al. 2019

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Background and Objectives: Alzheimer’s disease (AD) is a neurodegenerative disorder that deteriorates daily life due to loss of memory and cognitive impairment. It is believed that oxidative stress and cholinergic deficit are the leading causes of AD. Disease-modifying therapies for the treatment of AD are a challenging task for this century. The search for natural and synthetic agents has attracted the attention of researchers. The objective of this study was a scientific approach to search for most suitable remedy for AD by exploiting the potential of Albizia lebbeck (L.) seeds. Materials and Methods: Hydromethanolic extract of Albizia lebbeck seeds (ALE) was prepared by maceration. The plant was characterized by physico-chemical, phyto-chemical, and high-performance liquid chromatography (HPLC). Thirty-six Wistar albino rats were used in this study and divided into six groups (n = 6). Group I: normal control; Group II: disease control (AlCl3; 100 mg/kg); Group III: standard control (galantamine; 0.5 mg/kg); Groups IV–VI were treated ALE at 100, 200 and 300 mg/kg dose levels, respectively. All the treatments were given orally for 21 consecutive days. Y-maze, T-maze, Morris water maze, hole board, and open field behavioral tests were performed to analyze the cognitive impairment. Biochemical, histological, and computational studies were performed to support the results of behavioral tests. Results: HPLC analysis indicated the presence of quercetin, gallic acid, m-coumaric acid, and sinapic acid. ALE significantly improved the memory and cognitive impairments. Endogenous antioxidant stress biomarker levels and histopathological outcomes supported the therapeutic potential of A. lebbeck in AD. Cholinergic deficits were also ameliorated by ALE co-administration, possibly by the inhibition of hyperactive acetylcholinesterase (AChE). Docking studies supported the potential of ALE against AD. Conclusions: The data suggested that ALE has neuroprotective potential that can be exploited for beneficial effects to treat AD.

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Antioxidant activity and protective role on protein glycation of synthetic aminocoumarins

Cited by 27 publications

References 27 publications

Production of colorant powder from dragon fruit ( Hylocerecus polyrhizus ) peel: Bioactivity, heavy metal contamination, antimutagenicity, and antioxidation aspects

Production of colorant powder from dragon fruit ( Hylocerecus polyrhizus ) peel: Bioactivity, heavy metal contamination, antimutagenicity, and antioxidation aspects

Extracts Characterization and In Vitro Evaluation of Potential Immunomodulatory Activities of the Moss Hypnum cupressiforme Hedw.

Experimental and Computational Studies to Characterize and Evaluate the Therapeutic Effect of Albizia lebbeck (L.) Seeds in Alzheimer’s Disease

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