Antioxidant Activity and Protecting Health Effects of Common Medicinal Plants

Škrovánková, Soňa; Mišurcová, Ladislava; Machů, Ludmila

doi:10.1016/b978-0-12-394598-3.00003-4

Cited by 144 publications

(94 citation statements)

References 235 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Especially EOs, the aromatic oily liquid, are responsible for antimicrobial activities of medicinal plants, which is effective against microbial deterioration. Supercritical fluid extracts, methanol, and ethanol extracts, and water extracts are also utilized, but generally less effective (Skrovánková et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Essential oil ofPsidium cattleianumleaves: Antioxidant and antifungal activity

Castro

Victoria

Hartwig

et al. 2014

Pharmaceutical Biology

View full text Add to dashboard Cite

Context: Psidium cattleianum Sabine (Myrtacea) is rich in vitamin C and phenolic compounds, including epicatechin and gallic acid as the main components. Objective: To evaluate the antifungal and antioxidant capacity in vitro of the essential oil of araçá (EOA). The acute toxicity of the EOA also was evaluated in mice. Materials and methods: The leaves of the P. cattleianum were extracted by steam distillation. The antioxidant capacity was evaluated by in vitro tests [1,1-diphenyl-2-picryl-hydrazyl (DPPH), 2,2-azinobis(3-ethylbenzothiazoline-6-sulfonate) (ABTS), ferric ion reducing antioxidant power (FRAP), linoleic acid oxidation, thiobarbituric acid reactive species (TBARS)], and ex vivo analysis [TBARS, d-aminulevunilate dehydratase (d-Ala-D) and catalase activity, non-protein thiols (NPSH), and ascorbic acid levels]. The toxicity was studied in mice by a single oral administration of EOA; and the antifungal activity was performed with five strains of fungi. Results: The EOA exhibited antioxidant activity in the FRAP assay and reduced lipid peroxidation in the cortex (I max ¼ 32.90 ± 2.62%), hippocampus (IC 50 ¼ 48.00 ± 3.00 mg/ml and I max ¼ 32.90 ± 2.62%), and cerebellum (I max ¼ 45.40 ± 14.04%) of mice. Acute administration of the EOA by the oral route did not cause toxicological effects in mice (LD 50 4500 mg/ml). The EOA also showed antifungal activity through of the determination minimum inhibitory concentration (MIC) values ranging from 41.67 ± 18.04 to 166.70 ± 72.17 mg/ml for tested strains. Conclusion:The results of present study indicate that EOA possess antioxidant properties, antifungal and not cause toxicity at tested doses.

show abstract

Section: Discussionmentioning

confidence: 99%

Essential oil ofPsidium cattleianumleaves: Antioxidant and antifungal activity

Castro

Victoria

Hartwig

et al. 2014

Pharmaceutical Biology

View full text Add to dashboard Cite

show abstract

“…1,2 In recent years, a large number of secondary metabolites, including essential oils (EOs) are considered as valuable sources for ingredients in food and pharmaceutical industries, cosmetics and medicinal applications for prevention and/or treatment of many diseases including neurodegenerative diseases, rheumatoid arthritis, diabetes, respiratory diseases, cardiovascular diseases, cancers and inflammatory and oxidative diseases. 2,3 EOs extracted from MAPs, contain 300 compounds such as limonene, -pinene, -myrcene, -elemene, caryophyllene, humulene, -farnesene, cembrene, kaurene, eucalyptol, camphorene, camphor, carveol, limonene oxide, caryophyllene oxide, farnesol, humulene epoxide, -bisabolene oxide, carvacrol, catechol, eugenol, isopropyl alcohol, butyl alcohol, perillyl alcohol, geraniol, nerol, safrole, sesquiterpenes, rosmarinic acid, nerolidol, benzophenone, bornyl acetate, ethyl acetate, vernolide, cinnamaldehyde, acetophenone, helenin, fumarin, benzofuran etc., that exhibit many biological properties including antibacterial, antifungal, antioxidant, antiulcer, antispasmodic, antiproliferative, antitumor, antihepatotoxic, and others. EOs have thus become a focal point to improve and maintain human health needs and treatment of the diseases with less side effects.…”

Section: Introductionmentioning

confidence: 99%

“…EOs have thus become a focal point to improve and maintain human health needs and treatment of the diseases with less side effects. [3][4][5] Previous researches both in vivo and in vitro showed that EOs possess major bioactive components and molecules, which have chemoprevention and cancer suppression activities. EOs have also been demonstrated to have potentials to fight against cancer cells by multiple pathways and mechanisms, including of apoptosis and cell cycle arrest, angiogenesis and cell proliferation, of DNA damage and to repair signaling and activation of detoxification enzymes such as glutathione reductase, catalase glutathione, superoxide dismutase, peroxidase, etc.…”

Section: Introductionmentioning

confidence: 99%

In vitro Anticancer Activity and Antioxidant Properties of Essential Oils from Populus alba L. and Rosmarinus officinalis L. from South Eastern Anatolia of Turkey

Gezici¹,

Şekeroğlu²,

Kijjoa³

2017

IJPER

View full text Add to dashboard Cite

Background and Purpose:In recent years, essential oils (EOs) have been reported to possess interesting anti-tumor, anti-mutagenic and anti-carcinogenic activities against various cancer cells. Therefore, we aimed to investigate potential biological activities of EOs from white poplar (Populus alba L., Salicaceae) and rosemary (Rosmarinus officinalis L., Lamiaceae). Material and Methods: EOs from P. alba L. and R. officinalis L. were extracted by hydrodistillation. MTT assay was carried out to determine the potential antiproliferative and cytotoxic properties of the essential oils as well as their corresponding IC 50 , and the inhibition (%) calculated. Antioxidant activity was determined using 2,2-diphenyl-2-picrylhydrazyl (DPPH) assay, and lipid peroxidation capacity was evaluated using thiobarbituric acid-reactive substances (TBARS) method, and the values were calculated using the standards. Results: The EOs were evaluated for their in vitro cytotoxic, antioxidant and lipid oxidation activities. Regarding cytotoxic activity rosemary essential oil possessed strong inhibition (IC 50 = 3.06-7.38 µg/mL) of cell proliferation in comparison to that of P. alba L. (IC 50 = 10.53-28.16 µg/mL). Additionally, EO from R. officinalis L. was found to have higher antioxidant and lipid peroxidation capacities with IC 50 of 10.08 ± 0.15 and 1.76 ± 0.01, respectively. Conclusion: The results suggest that the EOs of both sources exhibited strong antiproliferative, cytotoxic and potent antioxidant properties and therefore they can have potential applications in the cancer treatment.

show abstract

“…Among the active constituents of rosemary, phenolic diterpenes and triterpenes have been the subject of intense research due to their potential benefits for human health [14,15]. In addition to their strong antioxidant properties, rosemary extracts rich in phenolic diterpenes and triterpenes have been also of interest for their anti-inflammatory and anticancer activities [15].…”

Section: Introductionmentioning

confidence: 99%

Comparative Proteomics to Investigate the In Vitro Antiproliferative Effect of Dietary Polyphenols Against K562 Leukemia Cells

Çelebi̇er¹,

Simó²,

Altınöz³

et al. 2015

Turk J Bioch

View full text Add to dashboard Cite

Comparative proteomics to investigate the in vitro antiproliferative effect of dietary polyphenols against K562 leukemia cells [Gıda kaynaklı polifenollerin K562 lösemi hücreleri üzerine in vitro çoğalmayı önleyici etkisinin karşılaştırmalı proteomik çalışmalarla incelenmesi] ABSTRACT Objective: The lack of success with classical targeted therapies in cancer treatment has forced researchers to employ either combined therapies or agents that interfere with multiple pathways.In this study, a proteomic evaluation was performed to understand the in vitro antiproliferative effect of dietary compounds against leukemia cells in proteome level. Typical human cell models of leukemia (i.e., wild K562 cells and multi-drug resistant leukemia cells K562/R) were treated with rosemary (Rosmarinus officinalis L.) extracts rich in polyphenols and a comparative proteomic study was performed to identify up-or down-regulated proteins by in vitro antiproliferative effect of polyphenols. Methods: The protein fraction from the polyphenol-treated and control K562 and K562/R cells were separated through two dimensional polyacrylamide gel electrophoresis (2DE) and their proteomic profiles compared by image analysis. The proteins identified to be overexpressed or underexpressed in K562 and K562/R cells after the polyphenol treatment were identified by MALDI-TOF/TOF MS. Results:The results in this study were evaluated to understand the mode of action of these dietary constituents against leukemia cell proliferation. Dietary polyphenols extracted from rosemary bring about the up regulation or down regulation of different proteins on leukemia cells. These proteins are related to tumorigenesis, cancer proliferation and antioxidant activity. Conclusion: Our results revealed that the studied rosemary extract rich in polyphenols induced the down regulation of adenine phosphoribosyl transferase and annexin A1 in K562/R cell lines and tubulin alpha-1C chain in K562 cell lines. According to the expression proteomics results in this study, it could be concluded that the rosemary polyphenols shows in vitro antiproliferative activity in K562 and K562/R leukemia cell lines. Key Words: Foodomics, Proteomics, 2-DE Electrophoresis, Leukemia, Rosemary polyphenols, MALDI-TOF Conflict of Interest: The authors have no conflict of interest. ÖZETAmaç: Kansere karşı bugüne kadar bilinen tedavi yöntemlerinin eksiklikleri araştırmacıları kombine tedavi yöntemlerine veya birden fazla metabolik yolağı etkileyen ajanlarla tedaviye yönlen-dirmiştir. Bu çalışmada, proteomik bir yaklaşım sergilenerek gıda kaynaklı bileşiklerin lösemi hücrelerine karşı in vitro çoğalmayı önleyici etkisi proteom düzeyinde açıklanmaya çalışılmıştır. Lösemi hücre hatları (wild tip (K562) ve çoklu ilaç dirençli (K562/R) lösemi hücre hattı) biberiyeden (Rosmarinus officinalis L.) elde edilen polifenollerce zengin ekstrelerle muamele edilmiştir. Karşılaştırmalı proteomik çalışmalar yapılarak polifenollerin in vitro çoğalmayı önleyici etkisiyle düşük veya yüksek miktarda ifade edilen proteinler...

show abstract

Antioxidant Activity and Protecting Health Effects of Common Medicinal Plants

Cited by 144 publications

References 235 publications

Essential oil ofPsidium cattleianumleaves: Antioxidant and antifungal activity

Essential oil ofPsidium cattleianumleaves: Antioxidant and antifungal activity

In vitro Anticancer Activity and Antioxidant Properties of Essential Oils from Populus alba L. and Rosmarinus officinalis L. from South Eastern Anatolia of Turkey

Comparative Proteomics to Investigate the In Vitro Antiproliferative Effect of Dietary Polyphenols Against K562 Leukemia Cells

Contact Info

Product

Resources

About