Antioxidant Activity and Nutritional Status in Anorexia Nervosa: Effects of Weight Recovery

Abstract

Few studies are focused on the antioxidant status and its changes in anorexia nervosa (AN). Based on the hypothesis that renutrition improves that status, the aim was to determine the plasma antioxidant status and the antioxidant enzymes activity at the beginning of a personalized nutritional program (T0) and after recovering normal body mass index (BMI) (T1). The relationship between changes in BMI and biochemical parameters was determined. Nutritional intake, body composition, anthropometric, hematological and biochemical parameters were studied in 25 women with AN (19.20 ± 6.07 years). Plasma antioxidant capacity and antioxidant enzymes activity were measured. Mean time to recover normal weight was 4.1 ± 2.44 months. Energy, macronutrients and micronutrients intake improved. Catalase activity was significantly modified after dietary intake improvement and weight recovery (T0 = 25.04 ± 1.97 vs. T1 = 35.54 ± 2.60μmol/min/mL; p < 0.01). Total antioxidant capacity increased significantly after gaining weight (T0 = 1033.03 ± 34.38 vs. T1 = 1504.61 ± 99.73 μmol/L; p < 0.01). Superoxide dismutase activity decreased (p < 0.05) and glutathione peroxidase did not change. Our results support an association between nutrition improvement and weight gain in patients with AN, followed by an enhancement of antioxidant capacity and catalase antioxidant system.

Oxidative Stress and Antioxidant Levels in Patients with Anorexia Nervosa after Oral Re‐alimentation: A Systematic Review and Exploratory Meta‐analysis

“…In a recent study, Oliveras-López reported in 25 participants with AN a significant increase in catalase activity (baseline: 25.04 ± 1.97 vs follow-up: 35.54 ± 2.60 μmol/min/mL; p < 0.01) as well as in total antioxidant capacity (from 1033.03 ± 34.38 to 1504.61 ± 99.73 μmol/L; p < 0.01). In this study, superoxide dismutase activity decreased significantly (baseline: 532.5 ± 93.4 vs follow-up: 281.4 ± 52.0 μmol/min/mL; p < 0.05), while glutathione peroxidase did not change significantly (Oliveras-López et al, 2015).…”

“…Six studies (Dostálová et al, 2010;Feillet et al, 2000;Haluzík et al, 1999;Oliveras-López et al, 2015;Russell et al, 1983;Umeki, 1988) involving 99 subjects demonstrated that weight gain was associated with a significant increase in the serum levels of the antioxidant albumin (SMD = 0.50, 95%CI = 0.18; 0.82, p = 0.002, I 2 = 16%; Fig. 1).…”

Study of salivary and serum vaspin and total antioxidants in anorexia nervosa

“…A distinct TAS reduction in serum of AN patients was already reported [23,24]. This is also reflected in measurements of single antioxidant markers such as albumin, apolipoprotein B, and uric acid [23,[25][26][27][28].…”

“…This is also reflected in measurements of single antioxidant markers such as albumin, apolipoprotein B, and uric acid [23,[25][26][27][28]. Diminished uric acid level was also observed in extended period of time after realimentation [29].…”

The Effects of Starvation and Refeeding on Oxidative Stress Parameters (MDA, SOD, GPx), Lipid Profile, Thyroid Hormones and Thyroid Histopathology in Male Wistar Rats

“…In the refeeding status, the body shifts back instantaneously to carbohydrate metabolism [2][3][4]. Studies on anorexia nervosa patients and fish species showed that the starvation period has prooxidant effects due to both increased lipid peroxidation levels and the reduced level of antioxidant defenses [5][6][7][8]. Capability of refeeding in anorexia nervosa patients for reducing the oxidative stress or increasing the levels of antioxidant markers is unknown.…”