Antioxidant activity and hepatoprotective effect of pomegranate peel and whey powders in rats

Ashoush, I. S.; El-Batawy, O. I.; El-Shourbagy, Gehan A.

doi:10.1016/j.aoas.2013.01.005

Cited by 59 publications

(45 citation statements)

References 22 publications

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“…This finding was in agreement with other researchers 17,18 . Again, mean serum AST and ALT levels were significantly lower in SC in comparison to that of CC.…”

Section: Discussionsupporting

confidence: 83%

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Effect of Punica Granatum (Pomegranate) on serum ALT and AST in Carbon tetrachloride induced liver damage in Wistar Albino Rats

Sadia

Akter

Afroz³

et al. 2016

J Bangladesh Soc Physiol

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Background: Liver diseases are associated with significant morbidity and mortality. Punica granatum may have free radical scavenging activity and it can be used for the prevention and treatment of liver damage. Objective: To observe the hepatoprotective effects of Punica granatum on CCl 4 induced liver damage in rats. Methods: The experimental study was carried out in the Dept of Physiology, Dhaka Medical Ccollege, Dhaka from July 2013 to June 2014. For this purpose, 36 wistar albino rats were studied. After acclimatization for 7 days, they were divided into two groups-control and experimental group. Control group were subdivided into BC (Baseline control), CC (CCl 4 treated control) and SC (Silymarin treated control). Experimental group were subdivided into CP-APT (CCl 4 pretreated and aqueous extract of pomegranate treated), CP-EPT (CCl 4 pretreated and ethanolic extract of pomegranate treated) and APP-CT (Aqueous extract of pomegranate pretreated and CCl 4 treated). Each sub group consisted of 6 rats. All rats received basal diet for 8 days. In addition to basal diet on 8 th day, BC received single dose olive oil and CC received CCl 4 . Rats of SC received silymarin for 8consecutive days . In experimental groups, CP-APT received aqueous extract of Pomegranate and CP-EPT received ethanolic extract of Pomegranate for 8consecutive days. Moreover, APP-CT received aqueous extract of Pomegranate for 8 consecutive days and CCl 4 only on 8 th day. All rats were sacrificed on 9 th day and then blood samples were collected. Serum ALT and AST levels were estimated by using standard laboratory kits. Statistical analysis was done one way ANOVA and Bonferroni test. Results: The mean serum AST and ALT levels were significantly (p<0.001) higher in CC in comparison to those of BC. Serum AST and ALT levels of all experimental groups were significantly (P<0.001) lower than CC. Silymarin used as a standard reference also exhibited significant hepatoprotective activity against CCl 4 induced hepatotoxicity Conclusion: From the result of present study it can be concluded that, Pomegranate may have hepatoprotective effect by lowering ALT and AST levels.

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“…This finding was in agreement with other researchers 17,18 . Again, mean serum AST and ALT levels were significantly lower in SC in comparison to that of CC.…”

Section: Discussionsupporting

confidence: 83%

“…Again this level was significantly higher in experimental groups in comparison to that of CC. These findings are in consistent with those of some other researchers 17 .…”

Section: Discussionsupporting

confidence: 83%

Effect of Punica Granatum (Pomegranate) on serum ALT and AST in Carbon tetrachloride induced liver damage in Wistar Albino Rats

Sadia

Akter

Afroz³

et al. 2016

J Bangladesh Soc Physiol

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“…28 The antioxidant activity of pomegranate peel powder and whey powder was evaluated and results showed that peel powder and whey powder exhibited antioxidant activity. 29 Other previous report demonstrated that leaf and peel exhibited very strong antioxidant activity 30 and extracts obtained from seeds exhibited various degrees of antioxidant activity and sour white peel had the highest potent antioxidant activity. 31 …”

Section: Anti-microbial Activitymentioning

confidence: 99%

Active Constituents of Pomegranates (Punica granatum) as Potential Candidates in the Management of Health through Modulation of Biological Activities

Rahmani¹,

Alsahli²,

Almatroodi³

2017

186

183

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Pomegranates fruits have innumerable health benefits and its implication in diseases cure have been widely recognized since ancient time. Moreover, pomegranate fruits, seeds and peels are intensively used in traditional medicine as a natural therapy. It contains numerous valuable ingredients such as flavonoids, ellagitannin, punicalagin, ellagic acid, vitamins and minerals. The principal constituents including punicalagins and ellagitannin are responsible for immeasurable health benefits due to its strong antioxidant activity. Additionally, constituents of pomegranate show health promoting effect through the modulation of physiological and biochemical pathways. Recent evidences suggested that pomegranates fruits, peels and seeds illustrate therapeutics implications in health management via inhibition of free radical effect and modulation of enzymes activity linked with diseases development and progression. In this review, we summarize the therapeutic role of pomegranate fruits, seeds and peels in the health managements based on in vitro and in vivo studies.

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“…Our research was finalized at the end of the 12 th hour. Ashoush et al (2013) investigated liver protective efficiency of three different extracts of pomegranate used for 28 days in liver injury by CCI4 and reported that all three extracts lowered MDA concentration. In the presented study no statistical variation was detected in MDA concentrations of Group 2.…”

Section: Discussionmentioning

confidence: 99%

Effects of Pomegranate (Punica granatum L.) on Paracetamol Induced Acute Hepatic Damage in Mice

Erfidan¹,

Akkol²,

Sevımlı³

et al. 2016

Kocatepe Vet J

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The most common cause of acute liver failure has been reported as paracetamol toxicity. There are some drugs that can be used as an antidote for acetaminophen toxicity, but in some cases these drugs are ineffective. The purpose of this study is to identify protective and side effects of lyophilized extract's from Punica granatum L. in acute liver injury model. In our study, 80 Swiss Albino mice were used. The research was conducted on two main groups. The mice in the side effect group were given pomegranate extracts at 100, 200 and 400 mg/kg doses. The trial group were administered mentioned doses of extracts and a single dose of paracetamol simultaneously. The results gained from biochemistry analysis demonstrated that lyophilized extract given along with paracetamol caused a significant decrease in serum AST, ALT, TP and TG levels. The pomegranate extract given to the experiment group led to a decrease in RBC, HB, HCT and LYMP levels. Histopathological evaluation demonstrated that the extract alone may cause liver injury ranging from mild to moderate. Yet the extract given simultaneously with paracetamol particularly may have a protective effect on liver in a certain dose of 200 mg/kg according to biochemistry results and in a certain dose of 400 mg/kg according to histopathological analysis. Measured AoA levels emphasize the antioxidant activity of the extract for trial group. The results obtained from the side effect group have emphasized possible reducing effect of antioxidant activity of lyophilized extract in mice.Key Words: Acetaminophen, Antioxidant activity, Hepatotoxicity, Hepatoprotective activity, Lythraceae. Farelerde Parasetamol ile İndüklenen Akut Karaciğer Hasarı Üzerine Narın(Punica granatum L.) Etkileri ÖZ Parasetamol toksisitesinin akut karaciğer hasarının en önemli nedeni olduğu rapor edilmiştir. Asetaminofen toksikasyonunda antidot olarak kullanılabilen müstahzarlar bulunmakla birlikte, bazı olgularda bu ilaçlar etkisiz kalabilmektedir. Bu çalışmanın amacı, akut karaciğer hasarı modelinde tam meyve liyofilize Punica granatum L. ekstresinin koruyucu etkinliğini ve yan etkilerini ortaya koymaktır. Çalışmada 80 Swiss Albino fare kullanıldı. Araştırma iki ana grup üzerinde yürütüldü. Yan etki grubundaki farelere 100, 200 ve 400 mg/kg dozunda nar ekstresi verildi. Deneme grubuna ise tek doz parasetamol ile birlikte, eş zamanlı olarak, bahsedilen dozlarda nar ekstresi uygulandı. Biyokimya analiz sonuçları parasetamol ile birlikte verilen liyofilize ekstrenin serum AST, ALT, TP ve TG düzeylerinde önemli oranda bir azalmaya neden olduğunu ortaya koydu. Deneme grubunda verilen nar ekstresi ise RBC, HB, HCT ve LENF konsantrasyonlarında bir düşüşe yol açtı. Histopatoloji analiz sonuçları tek başına verilen ekstrenin hafif-orta derecede karaciğer hasarına yol açabileceğini ortaya koydu. Parasetamol ile birlikte eş zamanlı verilen nar ekstresinin, biyokimya sonuçlarına göre, 200 mg/kg ve histopatoloji sonuçlarına göre ise 400 mg/kg dozlarında karaciğer üzerinde koruyucu etkinliği olabileceği bel...

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Antioxidant activity and hepatoprotective effect of pomegranate peel and whey powders in rats

Cited by 59 publications

References 22 publications

Effect of Punica Granatum (Pomegranate) on serum ALT and AST in Carbon tetrachloride induced liver damage in Wistar Albino Rats

Effect of Punica Granatum (Pomegranate) on serum ALT and AST in Carbon tetrachloride induced liver damage in Wistar Albino Rats

Active Constituents of Pomegranates (Punica granatum) as Potential Candidates in the Management of Health through Modulation of Biological Activities

Effects of Pomegranate (Punica granatum L.) on Paracetamol Induced Acute Hepatic Damage in Mice

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