Antioxidant activity and flavonoid composition of the new pancreoprotective preparation Pancreophyt

Николаев, С. М.; Николаева, И. Г.; Razuvaeva, Ya. G.; Dorzhiev, A. M.

doi:10.1007/s11094-011-0616-9

Cited by 8 publications

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References 2 publications

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“…Pyrolae herba functions by expelling wind and removing dampness, and promoting blood circulation for the regulation of menstruation and the relief of pain (14,15). In modern pharmacological studies, the active components of Pyrolae herba such as chimaphilin, ursolic acid and hyperoside had previously been shown to possess anti-inflammatory, antioxidant and antibacterial properties (16)(17)(18)(19)(20)(21). Recent studies have suggested that ursolic acid inhibits cell proliferation and downregulates the expression of anti-apoptotic and metastatic gene products, potentiating antitumor activity (22)(23)(24)(25).…”

Section: Introductionmentioning

confidence: 99%

Chemical constituents of volatile oil from Pyrolae herba and antiproliferative activity against SW1353 human chondrosarcoma cells

Cai

et al. 2013

International Journal of Oncology

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Abstract. The objective of the present study was to identify chemical constituents of volatile oil from Pyrolae herba (PHVO) and evaluate the antiproliferative activity of PHVO against SW1353 human chondrosarcoma cells. The volatile oil from Pyrolae herba was prepared by hydrodistillation and characterized by gas chromatography-mass spectroscopy (GC-MS). A total of 12 components in PHVO were identified representing 81.62% of the total integrated chromatographic peaks. The major compounds were found to be n-hexadecanoic acid (29.29%), cedrol (17.08%), 6,10,14-trimethyl-2-pentadecanone (9.59%) and cis-9-octadecadienoic acid (8.23%). The antiproliferative activity of PHVO against SW1353 cells was investigated using MTT assay, flow cytometry and western blot analysis. Our results demonstrated that PHVO inhibited SW1353 cell viability in a dose-and time-dependent manner. Furthermore, PHVO treatment decreased the number of cells entering the S phase and caused a reduction in the expression of cyclin D1, cyclin-dependent kinase (CDK)4 and CDK6, whereas it caused an increase in the expression of p21. PHVO demonstrated potent antitumor activity against SW1353 cells, suggesting its potential use as a therapeutic agent in the treatment of chondrosarcoma. IntroductionChondrosarcoma is the most common primary malignant bone tumor in children and adolescents, comprising almost 60% of all bone sarcomas (1,2). To date, the main treatments for patients with osteosarcoma are surgical resection and chemotherapy (3). However, despite advances in chemotherapy and surgery, the survival rate for osteosarcoma has reached a plateau and 40% of osteosarcoma patients eventually succumb to the disease; thus, there is an urgent need for the development of novel therapeutic agents (4).Over the past few years, natural products have attracted extensive attention due to their relatively few side-effects and have been used in clinical practice for thousands of years as important alternative remedies for a variety of diseases (5-7). Moreover, natural products are an attractive source of new therapeutic candidate compounds, which make an enormous contribution to drug discovery today (8). An analysis of the number of chemotherapeutic agents and their sources indicates that over 60% of approved drugs are derived from natural compounds (9). Several plant-derived compounds are currently successfully employed in disease treatment. For instance, arteannuin, which was isolated from Artemisia annua, has been used for the treatment of malaria and the vinca alkaloid isolated from the periwinkle Catharanthus roseus has been used for the treatment of cancer (10,11). Volatile oils are a type of secondary plant metabolite, and have been shown to exhibit antioxidant and antibacterial activities (12,13).Pyrolae herba listed in Chinese Pharmacopoeia is commonly used in traditional Chinese medicine for the treatment of cancer, hypertension, coronary heart disease and various inflammatory diseases, including rheumatoid arthritis and arthralgia. Pyrolae herba function...

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Section: Introductionmentioning

confidence: 99%

Chemical constituents of volatile oil from Pyrolae herba and antiproliferative activity against SW1353 human chondrosarcoma cells

Cai

et al. 2013

International Journal of Oncology

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Metabolomic Profile of the Genus Inula

Seca

Pinto

Silva

2015

Chemistry & Biodiversity

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Plants have a long history as therapeutics in the treatment of human diseases and have been used as source of medicines for ages. Searching for new biologically active natural products, many plants and herbs are screened for natural products with pharmacological activities. In this field, the genus Inula, which comprises more than 100 species, several of them being used in traditional medicine, is very important, especially due to the finding that several of the isolated pure secondary metabolites proved to possess important biological activities. Inula species have been reported as rich sources of sesquiterpene lactones, including eudesmanes, germacranes, guaianes, and dimeric structures, and since 2006 ca. 400 secondary metabolites, including more than 100 new natural products, some of them with relevant pharmacological activities, have been identified. Herein, we critically compile and update the information regarding the types of secondary metabolites found in the genus Inula and the progress in their isolation.

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Antitumor Essential Oils

Magalhães

Sousa

2015

Bioactive Essential Oils and Cancer

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Antioxidant activity and flavonoid composition of the new pancreoprotective preparation Pancreophyt

Cited by 8 publications

References 2 publications

Chemical constituents of volatile oil from Pyrolae herba and antiproliferative activity against SW1353 human chondrosarcoma cells

Chemical constituents of volatile oil from Pyrolae herba and antiproliferative activity against SW1353 human chondrosarcoma cells

Metabolomic Profile of the Genus Inula

Antitumor Essential Oils

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