Antioxidant activity and DNA damage protection of mung beans processed by solid state fermentation with Cordyceps militaris SN-18

Xiao, Yu; Zhang, Qiuqin; Miao, Junqing; Rui, Xin; Li, Teng; Dong, Mingsheng

doi:10.1016/j.ifset.2015.06.006

Cited by 24 publications

(19 citation statements)

References 52 publications

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“…(40% level) shows the presence of maximum DDPA as compared to the extracts prepared from control and other rusk samples. Xiao et al () demonstrated that the presence of phenolic compounds in the extracts contributes to their effectiveness against DNA scission, which is mediated by hydroxyl radicals generated during Fenton's reaction with model DNA.…”

Section: Resultsmentioning

confidence: 99%

Effect of incorporation of flaxseed to wheat rusks: Antioxidant, nutritional, sensory characteristics, and in vitro DNA damage protection activity

Kaur

Purewal

2018

J Food Process Preserv

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The objective of this study was to evaluate the nutritional value and acceptance of rusks prepared from three flaxseed cultivars (LC‐2023, Jawahar‐27, Jeevan) containing four different concentrations of flaxseed powder (FP) as partial replacement for wheat flour. The rusks were also evaluated for their total phenolic content and various antioxidant properties. The results revealed that there was a positive increase in ash, fat, protein, and fiber content of rusks with the increase in flaxseed level. The scavenging activity toward 2,2‐diphenyl‐1′‐picrylhydrazyl, 2,2′‐azinobis(3‐ethylbenzothiazoline‐6‐sulfonic acid), and hydroxyl radicals was observed to be higher for flaxseed‐incorporated rusks in comparison to wheat rusks only. All flaxseed‐containing extracts protected DNA from damaging effect produced during Fenton' reaction as confirmed by the presence of DNA bands. The results for sensory parameters showed that color of rusks became darker with the increase in level of FP addition. Practical applications In this study, the antioxidant potential of flaxseed incorporated rusks was studied in relation to their total phenolic content and their DNA damage protection activity (DDPA). The addition of flaxseed powder (FP) caused an increment of phenolics and antioxidant activity of rusks. The standardized rusk was acceptable up to 10% of flaxseed level based on the sensory attributes of rusk. Among all the cultivars studied, “LC‐2023” cv. exhibited the best nutritional and antioxidant characteristics and DDPA in comparison to other cultivars. Considering the results obtained in this study, rusks enriched with 10% of FP were suggested to be nutritionally superior with an acceptable sensory score and enhanced phytochemicals profile.

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Section: Resultsmentioning

confidence: 99%

Effect of incorporation of flaxseed to wheat rusks: Antioxidant, nutritional, sensory characteristics, and in vitro DNA damage protection activity

Kaur

Purewal

2018

J Food Process Preserv

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“…The formation of ROS and FRs is a continuous phenomenon that occurs during normal respiration process. These byproducts are accepted as sole factors for OS-mediated injuries in living organisms Xiao et al 2015;Salar et al 2017b). The formation of bioactive antioxidants within living organisms in response to ROS and FRs is one of the defense mechanisms.…”

Section: Oxidative Stress (Os) and Hydroxyl-mediated Dna Damagementioning

confidence: 99%

“…Experimental studies are being carried out on various resources to identify the relationship among organelles, DNA damaging factors and repair systems. Significant DNA damage protection activity in extracts such as [Barley (Salar et al 2017a); pearl millet (Salar et al 2017b); Mung beans (Xiao et al 2015); Grape seeds (Aybastier et al 2018); Ashtvarga (Giri et al 2017); Amazon moss (Fernandes et al 2018);Sugarcane (Abbas et al 2014); Eulophia nuda Lindl. (Kumar et al 2013); Honey (Habib et al 2014); Carissa carandas leaves (Verma et al 2015); Bael flower (Chandrasekara et al 2018); Teucrium polium and Stachys iberica (Tepe et al 2011); Sphallerocarpus gracilis seeds (Gao et al 2014); Garcinia gracilis leaves (Supasuteekul et al 2016) was reported.…”

Section: Use Of Natural Resources For Dna Damage Protection Activitymentioning

confidence: 99%

DNA damage protection: an excellent application of bioactive compounds

Kaur

Purewal

Sandhu

et al. 2019

Bioresour. Bioprocess.

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Discovery of deoxyribonucleic acid (DNA) solved out the mystery of cellular functioning and abnormality in cellular metabolism. Understanding the coding of DNA resulted in enormous medical growth and helps the researchers in finding the genes which trigger major chronic diseases in humans. Further, the structural and sequential analysis brought humans into a new era of medical industry. The advancement in understanding of DNA could be a boon for agricultural sector as it allowed the farmers/breeders to choose better varieties with disease resistant features. In developing nations where the staple foods suffers with micronutrient deficiencies and stress conditions, DNA modifications and repair mechanism could solve out their problems. The role of DNA damaging factors and repair mechanism plays a crucial role in occurrence of certain disorders. Extracts prepared from various natural resources could either stop or slow down the process of DNA damage. This will help to eradicate major disorders related to DNA from human race. Further on the basis of type and dose of natural extracts, it would ease the planning of diets for patients suffering from chronic disorders. which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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“…In recent years, the identification of free radical scavengers that inhibit both DNA damage and inflammation production has received extensive attention. Phenolics are present in various plants and fungi, which are an important group of secondary metabolites [ 8 ]. Phenolics possess significant free radical scavenging properties and may protect against cellular damage caused by free radicals, thereby taking precautions against various diseases.…”

Section: Introductionmentioning

confidence: 99%

Metal Chelating, Inhibitory DNA Damage, and Anti-Inflammatory Activities of Phenolics from Rambutan (Nephelium lappaceum) Peel and the Quantifications of Geraniin and Corilagin

Li²,

Hou

et al. 2018

Molecules

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Whereas the preparation and biological properties of rambutan peel phenolics (RPP) were explored in our previous studies, the metal chelating, inhibitory DNA damage, and anti-inflammatory activities of RPP were evaluated and the important phenolics of RPP quantified in this study. Results showed that RPP had high Fe2+ and Cu2+-chelating activities with EC50 of 0.80 mg/mL and 0.13 mg/mL, respectively. RPP effectively decreased the production of hydroxyl radical with IC50 of 62.4 μg/mL. The protective effects of RPP against AAPH-induced DNA damage were also explored. RPP efficiently inhibited peroxyl radical-induced plasmid DNA strand breakage. The anti-inflammatory effects of RPP were determined using a lipopolysaccharide (LPS)-induced RAW 264.7 cell model. RPP significantly inhibited the production of nitric oxide (NO) and controlled the levels of inducible NO synthase mRNA in LPS-induced RAW 264.7 cells. The inhibitory activity increased in a dose-dependent manner. The above bioactivity of RPP was associated with its phenolic content and phenolic profiles. Furthermore, the contents of geraniin and corilagin in RPP were determined by an ultra-high performance liquid chromatography coupled with triple quadruple mass spectrometry (UPLC-QQQ-MS), showing 140.02 and 7.87 mg/g extract dry weight. Thus, RPP has potential applications as a novel nutraceutical and functional food in health promotion.

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Antioxidant activity and DNA damage protection of mung beans processed by solid state fermentation with Cordyceps militaris SN-18

Cited by 24 publications

References 52 publications

Effect of incorporation of flaxseed to wheat rusks: Antioxidant, nutritional, sensory characteristics, and in vitro DNA damage protection activity

Effect of incorporation of flaxseed to wheat rusks: Antioxidant, nutritional, sensory characteristics, and in vitro DNA damage protection activity

DNA damage protection: an excellent application of bioactive compounds

Metal Chelating, Inhibitory DNA Damage, and Anti-Inflammatory Activities of Phenolics from Rambutan (Nephelium lappaceum) Peel and the Quantifications of Geraniin and Corilagin

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