Antioxidant activity and cytotoxic profile of Chuquiraga spinosa Lessing on human tumor cell lines: A promissory plant from Peruvian flora

Herrera-Calderon, Oscar; Tinco-Jayo, Johnny Aldo; Franco-Quino, César; Chumpitaz-Cerrate, Víctor; Castro-Pari, Wendy; Castillo-Romero, Patricia C.; Arroyo-Acevedo, Jorge Luis

doi:10.12980/apjtd.7.2017d6-436

Cited by 14 publications

(17 citation statements)

References 19 publications

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“…The lipid-lowering effect could directly influence the development of cancer. 23 It has been evidenced in preclinical studies that statins show promising results in pancreatic cancer, liver cancer, colorectal cancer, and GC. 24 …”

Section: Discussionmentioning

confidence: 99%

Preventive effect of <em>Oenothera rosea</em> on N-methyl-N-nitrosourea- (NMU) induced gastric cancer in rats

Almora-Pinedo

Arroyo-Acevedo²,

Herrera-Calderon³

et al. 2017

CEG

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BackgroundCurrently, gastric cancer (GC) is considered a public health problem worldwide. Using medicinal plants for the prevention of chronic diseases such as cancer constitutes new alternatives in traditional medicine. Oenothera rosea (OR) could be an option, but it needs to be evaluated.AimThe main objective of this study was to evaluate the protective effect of OR extract on N-methyl-N-nitrosourea (NMU)-induced GC in rats.MethodsIn total, 80 male Holtzman rats were randomized into five groups. Group A received the saline solution (5mL/kg), group B received NMU 500 μg/kg (cancer inductor) by oral administration for 16 weeks, and groups C, D, and E were treated with OR extract (100, 200, and 300 mg/kg, respectively) and NMU in order to evaluate the preventive effect on cancer induced by NMU for 16 weeks. Blood and histological samples of stomachs were collected to determine histopathological, biochemical, and hematological parameters between different experimental groups.ResultsGroups C, D, and E presented less histopathological changes such as anaplastic and hyperplastic cells, compared with group B. Hematological and biochemical parameters were recorded, and superoxide dismutase, malondialdehyde, and nitric oxide levels were statistically less than those of NMU group (P<0.05, P<0.01, and P<0.01).ConclusionConsidering the histopathological signs and the antioxidant activity in vivo as well as hematological and biochemical parameters of ethanolic extract of OR, we concluded that its administration in rats has a protective effect on GC, which is induced experimentally. This species could be studied in clinical trials for patients with GC in the future.

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Section: Discussionmentioning

confidence: 99%

Preventive effect of <em>Oenothera rosea</em> on N-methyl-N-nitrosourea- (NMU) induced gastric cancer in rats

Almora-Pinedo

Arroyo-Acevedo²,

Herrera-Calderon³

et al. 2017

CEG

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“…It was performed according to the procedure described by Herrera et al 17 The standard solution includes 300 mM acetate buffer pH 3.6; 10 mM 2,4,6 -tripyridyl-triazine (TPTZ) dissolved in a solution of HCl 40 mM Y 20 mM FeCl3.6H 2 O solution. The working solution (WS) was obtained by mixing and heating to 37°C, 25 mL of acetate buffer with 2.5 mL TPTZ solution and 2.5 ml of FeCl 3 solution.…”

Section: Determination Of Antioxidant Activity By the Methods Of Reducmentioning

confidence: 99%

Antioxidant Activity of the Germinated Seed of Four Varieties of Amaranthus Caudatus L. from Peru

Aguilar-Felices

Romero-Viacava

Enciso-Roca

et al. 2019

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Introduction: The objective of this study was to determine the antioxidant activity of four varieties of germinated seeds of Centenario, Cristalino, Oscar Blanco and Taray of Amaranthus caudatus L. compared to non-germinated seeds. Material and Methods: The determination of total phenols was carried out by using Folin-Ciocalteu, total flavonoids by the method of aluminum chloride and the antioxidant activity by the methods of DPPH, ABTS and FRAP. Results: Cristalino variety had the highest germination (3.0 cm of height) and all varieties had a 50% germination rate. Cristalino and Taray varieties had the highest content of total phenolics (GAE 32.92 and 35.00 mg/g sample), Cristalino variety had higher content of flavonoids (580.95 mg QE/g) (P < 0.05); Cristalino and Taray varieties showed greater scavenging activity of DPPH radical (151.85 and 151.38 mg TE/g sample), ABTS (178.09 and 180.18 mg TE/g sample); and reducing capacity of the ferric ion (FRAP) (132.75 and 136.42 mg TE/g of sample). Conclusion: Sprouts of Cristalino and Taray varieties had higher antioxidant activity than non-germinated seeds and they are directly related to higher content of total phenols and flavonoids.

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“…Se han identificado varios compuestos químicos a partir de extractos alcohólicos e hidroalcohólicos de las partes aéreas de C. spinosa (Tabla 3). Las principales clases de compuestos que se han descrito incluyen flavonoides, compuestos fenólicos, saponinas, alcaloides, taninos, terpenos y esteroides (Arroyo-Acevedo et al 2017, Arroyo-Acevedo et al 2018, Herrera-Calderon et al 2017. Casado et al (2011) realizaron un estudio fitoquímico de tres extractos (metanólico, metanólico 50% y acuoso) de las partes aéreas de C. spinosa.…”

Section: Composición Fitoquímicaunclassified

Etnobotánica, farmacología, fitoquímica y usos medicinales de Huamanpinta en el Perú – Chuquiraga spinosa Less. (Asteraceae)

Perez-Chauca

Saldaña-Bobadilla²,

Minchan-Herrera³

2020

Ethnobot. Res. App.

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Antecedentes: Chuquiraga spinosa Less., conocida como "Huamanpinta", es una planta medicinal importante en medicina convencional para el tratamiento de diversas enfermedades tales como trastornos del sistema urinario, vaginitis e infección vaginal, inflamación renal y prostática, cáncer de próstata, diurético e impotencia sexual. Este artículo de revisión documenta información actualizada sobre C. spinosa, incluyendo estudios etnobotánicos, usos medicinales, composición fitoquímica, actividades farmacológicas, toxicidad y comercialización.Métodos: Toda la información proporcionada sobre C. spinosa se recopiló utilizando bases de datos electrónicas GoogleScholar, Scopus, PubMed y ScienceDirect.Resultados y discusión: Se registraron un total de 338 documentos de los cuales 49 cumplieron con los criterios de elegibilidad. Los estudios fitoquímicos sobre C. spinosa revelaron la presencia de compuestos químicos tales como: flavonoides, compuestos fenólicos, saponinas, alcaloides, taninos, terpenos y esteroides. Los extractos alcohólicos de las partes aéreas de C. spinosa mostraron diversas actividades in vitro e in vivo como actividad antioxidante, antiinflamatoria, antifúngica, inmunomoduladora y protectora frente al síndrome metabólico e hipercolesterolemia. C. spinosa reveló poseer un potencial terapéutico como agente citotóxico frente a diversas líneas celulares de cáncer. Conclusiónes:A pesar del potencial terapéutico que se reporta en la literatura sobre esta especie, las actividades biológicas fueron estudiadas a partir de los extractos alcohólicos, desconociéndose los mecanismos completos en los que se basan estos efectos. No se realizaron estudios que permitan aislar moléculas activas involucradas en los efectos farmacológicos.Se deben realizar más investigaciones que evalúen esta actividad y estudios clínicos para demostrar su papel como agente anticancerígeno en el futuro.

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Antioxidant activity and cytotoxic profile of Chuquiraga spinosa Lessing on human tumor cell lines: A promissory plant from Peruvian flora

Cited by 14 publications

References 19 publications

Preventive effect of <em>Oenothera rosea</em> on N-methyl-N-nitrosourea- (NMU) induced gastric cancer in rats

Preventive effect of <em>Oenothera rosea</em> on N-methyl-N-nitrosourea- (NMU) induced gastric cancer in rats

Antioxidant Activity of the Germinated Seed of Four Varieties of Amaranthus Caudatus L. from Peru

Etnobotánica, farmacología, fitoquímica y usos medicinales de Huamanpinta en el Perú – Chuquiraga spinosa Less. (Asteraceae)

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