Antioxidant Activity and Biological Evaluation of Hot-water Extract of Artemisia monosperma and Capparis spinosa Against Lead Contamination

Al-Soqeer, A.

doi:10.3923/rjb.2011.11.20

Cited by 15 publications

(11 citation statements)

References 11 publications

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“…But the extract of this plant reduced the elevated concentrations of urea to normal values. This protective effect may be due to high level of total antioxidant contents in this plant (Al-Soqeer, 2011 ▶). Ene-ojo et al (2013) ▶, reported that two and six rats out of 24 died respectively at concentrations of 50, 100 mg/kg of chloroformic extract of Artemisia maciverae , whereas, at a concentration of 200 mg/kg all the animals died.…”

Section: Discussionmentioning

confidence: 99%

The Antioxidant Effects of Artemisia deserti Ethanolic Extract and Diazinon on Male Rat Kidney

Noori

Amjad

Yazdani

2016

Zahedan J Res Med Sci

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Background: Artemisia is a diverse genus of Asteraceae family that has pharmacological effects such as antiinflammatory, anticancer, antidiabetic and is used for treatment of diseases, including antioxidant effects against oxidative stress. Objectives: This study investigated the antioxidant effects of Artemisia deserti Krasch extract and diazinon. Materials and Methods: In this experimental study, Artemisia deserti was collected from Isfahan, Iran then 20 g of flower powder was extracted with 150 mL 80% ethanol and the 100, 200 mg/kg concentrations of ethanolic extract were prepared. The 48 male rats were divided in to 6 groups include the 1. Control, 2. diazinon treated group, 3. Diazinon + extract (100 mg/kg), 4. Diazinon + extract (200 mg/kg), 5 and 6. extract treated groups (100 and 200 mg/kg) respectively. The blood samples were collected and the rate of urea, uric acid, creatinine, serum total antioxidant and MDA (malondialdehyde) were assayed in serum. Also, the kidney tissue was isolated for histopathological examination. Finally, the statistical comparisons were done with one-way ANOVA test. Results: The rate of creatinine and MDA were changed significantly in the group that had received the extract (200 mg/kg) alone. Moreover, results indicate tissue disorders in all groups compared to controls, including the degeneration of proximal and distal tubules, atrophied glomeruli and accumulation of inflammatory cells. These abnormalities were associated with oxidative stress in some groups. Conclusions: Diazinon cause oxidative stress and kidney disorders, similar to the effect of artemisinin on kidney; therefore, simultaneous use of these compounds could enhance the toxic effects.

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Section: Discussionmentioning

confidence: 99%

The Antioxidant Effects of Artemisia deserti Ethanolic Extract and Diazinon on Male Rat Kidney

Noori

Amjad

Yazdani

2016

Zahedan J Res Med Sci

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“…In another in vivo study, the protective effects of a hot‐water extract of C . spinosa were evaluated on lipid peroxidation induced by lead acetate in rats (Al‐Soqeer, ). In particular, biochemical alterations such as glutathione‐S‐transferase activity reduction, and increases in serum triglycerides, urea, aspartate transaminase (AST) and alanine transaminase (ALT) were found to return to normal values after an administration of C .…”

Section: Pharmacological Effects Of C Spinosamentioning

confidence: 97%

“…spinosa hot‐water extract. This activity is assumed to be driven by flavonoids such as quercetin and kaempferol derivatives (Al‐Soqeer, ).…”

Section: Pharmacological Effects Of C Spinosamentioning

confidence: 99%

Pharmacological Effects of Capparis spinosa L.

Nabavi

Maggi

Daglia

et al. 2016

Phytotherapy Research

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Medicinal plants have been known as one of the most important therapeutic agents since ancient times. During the last two decades, much attention has been paid to the health-promoting effects of edible medicinal plants, because of multiple beneficial effects and negligible adverse effects. Capparis spinosa L. is one of the most common medicinal plants, used widely in different parts of the world to treat numerous human diseases. This paper aims to critically review the available scientific literature regarding the health-promoting effects of C. spinosa, its traditional uses, cultivation protocols and phytochemical constituents. Recently, a wide range of evidence has shown that this plant possesses different biological effects, including antioxidant, anticancer and antibacterial effects. Phytochemical analysis shows that C. spinosa has high quantities of bioactive constituents, including polyphenolic compounds, which are responsible for its health-promoting effects, although many of these substances are present in low concentrations and significant changes in their content occur during processing. In addition, there is negligible scientific evidence regarding any adverse effects. Different health promotion activities, as well as tremendous diversity of active constituents, make C. spinosa a good candidate for discovering new drugs. However these findings are still in its infancy and future experimental and clinical studies are needed.

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“…According to Sher and Alyemeni (2010), many parts of caper are still being used as drugs and traditional healers in Saudi Arabia describe oral administration of dried fruits of C. spinosa with water to treat hypertension and diabetic complications. Hot-water extract of C. spinosa prevents lead acetate-induced lipid oxidation in rats (Al-Soqeer, 2011).…”

Section: Introductionmentioning

confidence: 98%

Assessment of the antioxidant properties of the caper fruit (Capparis spinosa L.) from Bahrain

Allaith

2016

Journal of the Association of Arab Universities for Basic and A

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Capparis spinosa, a wild plant of the family Capparidaceae, is said to be native to the Mediterranean basin and found in many parts. This shrub can grow very well on dry heat and under intense sunlight and can tolerate low temperature. Caper berries from different locations of contrasting habitats were evaluated for their antioxidant capacities using several methods, including reduction of ferrictripiridyltriazine [Fe(III)-TPTZ] (FRAP assay), 1,1-diphenyl-2-picrylhydrazyl radical scavenging (DPPH assay), and [2,2 0-azinobis(3-ethylbenzothiazoline-6-sulfonic acid)] scavenging (ABTS assay). Total free phenolics, total flavonoids, and total carotenoids were also examined. The mean mmol Trolox equivalent/kg fresh weight for FRAP was 9.059 ± 1.450, DPPH 6.131 ± 0.607, and ABTS 8.127 ± 2,017. Mean % DPPH scavenging activity was 37.67% ± 7.19 and mean % ABTS scavenging activity was 31.29% ± 7.76. Partitioning studies revealed a higher antioxidant-antiradical capacity in the seed as compared to the flesh, and these capacities were associated more with hydrophobic and not lipophilic constituents. Antioxidant capacities strongly correlated with the total free phenolics, total flavonoids, and total carotenoids. Findings of this study contribute to the recent increase in scientific interest of a wild fruit which should be reconsidered for its antioxidant constituencies and characteristics.

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Antioxidant Activity and Biological Evaluation of Hot-water Extract of Artemisia monosperma and Capparis spinosa Against Lead Contamination

Cited by 15 publications

References 11 publications

The Antioxidant Effects of Artemisia deserti Ethanolic Extract and Diazinon on Male Rat Kidney

The Antioxidant Effects of Artemisia deserti Ethanolic Extract and Diazinon on Male Rat Kidney

Pharmacological Effects of Capparis spinosa L.

Assessment of the antioxidant properties of the caper fruit (Capparis spinosa L.) from Bahrain

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