Antioxidant activity and acute toxicity of two Lagenaria siceraria (Molina) Standl. varieties from Sudan

Abstract

<p>The present study was conducted to evaluate the antioxidant capacity and acute toxicity of the methanol extract of two <em>Lagenaria siceraria</em> (<a href="https://en.wikipedia.org/wiki/Juan_Ignacio_Molina">Molina</a>) <a title="Paul Carpenter Standley" href="https://en.wikipedia.org/wiki/Paul_Carpenter_Standley">Standl.</a> varieties of dried seeds, Sweet gourd Water Jug (WJ) and bitter gourd Basket Ball (BB). The seed extracts were tested for their total phenolic contents (TPC), total flavonoid contents (TFC), ferric reducing antioxidant power (FRAP) and scavenging activity to the stable free radical 2,2-diphenyl-1-picrylhydrazyl (DPPH). Both dried seed extracts were then tested for acute toxicity at doses 2 and 5 g kg<sup>-1</sup> each. Sixty female and male rats were assigned into five groups per sex. Four groups were given low and high doses of each dried seed extract and the fifth group was given 10 % Tween 20 as a control. Kidneys and livers of all rats were assessed for biochemistry and histopathology. The seed extract of WJ revealed higher TPC, FRAP and DPPH activities compared to BB seeds, while TFC results were reversed. Toxicologically, no toxicity signs were recorded in animals. Biochemistry results were within the normal ranges with a slight increase in bilirubin and Alanine aminotransferase (ALT), and histology of kidneys and livers showed normal architecture. In conclusion, WJ and BB dried seed extracts exhibited high antioxidant activity suggesting promising therapeutic regimen against oxidative stress.</p>

Functional Low- Fat Soft Cheese Supplemented With Bottle Gourd (Lagenariasiceraria) Seeds

“…Results in Table (5) show the total phenolic content (TPC) and antioxidant activity of UF-soft cheese supplemented with different ratios of BGSP (3%, 6% and 9%) and control. It was obvious that, as the concentration of BGSP increased; the TPC and antioxidant activity of the resultant cheese considerably increased, which could be due to the fact that BGS contains a high percentage of antioxidants [46][47][48]. From the obtained results it could be noticed that, the highest amount of TPC was from functional low fat UF-soft cheese supplemented with 9% BGSP (P 3 ) followed by cheese made from 6% BGSP(P 2 ).…”

Changes in Lung Cancer Cell Line Affected by Cytotoxicity of Lagenaria Siceraria Plant Extract

“…Medicinal plants are still recognized as a cheap and safe natural resource as less toxic drugs worldwide. Many developing countries have relied more on traditional herbs than chemical drugs to treat their diseases (Mariod et al, 2020;Kubde et al, 2010). On the other hand, cell culture has been dramatically progressed to measure the cytotoxicity of chemicals, drugs, pesticides, and in vitro analysis of all-natural and synthetic compounds, etc.…”