Antioxidant activities of polysaccharides from Lentinus edodes and their significance for disease prevention

Chen, Huoliang; Jin, Ying; Li, Junjie; Yu, Min

doi:10.1016/j.ijbiomac.2011.10.027

Cited by 106 publications

(43 citation statements)

References 29 publications

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“…Previous publications indicate that some mushroom polysaccharides, isolated from Lentinus edodes, Agaricus nevoi, Coprinus comatus and Daedalea quercina, are found to have strong antioxidant activity (Asatiani et al, 2008;Chen et al, 2012). In addition, most of mushroom polysaccharides are relatively nontoxic and do not cause significant side effects (Wasser & Weis, 1999;Zhang et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Extraction optimization of antioxidant polysaccharides from Auricularia auricula fruiting bodies

2015

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The extraction conditions (liquid-solid ratio, temperature and time) of antioxidant polysaccharides from Auricularia auricula fruiting bodies (AAFB) were optimized using response surface methodology (RSM). The Box-Behnken experimental results showed the optimum extraction conditions as follows: a liquid-solid ratio of 38.77 mL/g, a temperature of 93.98 °C and a time of 3.41 h. Under these conditions, the maximal polysaccharide yield was 10.46 g/100 g. In addition, AAFB polysaccharides exhibited stronger antioxidant activities by evaluating of Fe 2+ -chelating ability and hydroxyl radical scavenging activity with IC 50 values of 0.43 and 0.38 mg/mL, respectively. These results indicated that AAFB polysaccharides might be potentially used as a natural antioxidant.

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Section: Introductionmentioning

confidence: 99%

Extraction optimization of antioxidant polysaccharides from Auricularia auricula fruiting bodies

2015

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“…In the synthesis of melanin pigments, tyrosinases are responsible for coloring hairs, skin, and eyes and also for the treatments of some dermatological hyper pigmentation illness connected with overproductions of melanin (Chen, Ying, Li, & Yua, 2012). Skin hyper pigmentation can be depended on either an increased number of melanocytes or activity of melanogenic enzymes.…”

Section: Resultsmentioning

confidence: 99%

Anticancer, antithrombotic, antityrosinase, and anti‐α‐glucosidase activities of selected wild and commercial mushrooms from Pakistan

Sharif

Atta

Huma

et al. 2018

Food Science & Nutrition

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Mushrooms have been accepted as nutraceutical foods because of their high nutritional and functional values. They have also gained interest due to their medicinal properties, economic importance, and organoleptic merit. In this study, wild Ganoderma lucidum and four commercial mushrooms, that is, Pleurotus ostreatus, Volvariella volvacea, Hericium erinaceus, and Lentinus edodes from Pakistan were screened for their biological activities such as anticancer, antityrosinase, anti‐α‐glucosidase, and antithrombotic activities from their methanol, ethanol, and water extracts. Enzyme inhibition assay showed that selected mushrooms are potent inhibitors with %age inhibition ranging from 19.00% to 80.91%, and 32.85% to 83.38% for tyrosinase and α‐glucosidase, respectively. The best tyrosinase inhibition was shown by P. ostreatus whereas L. edodes was found best as α‐glucosidase inhibitor. These mushrooms were tested against cancer cell lines including HT‐29 colon and H‐1299 lungs carcinoma cell lines. G. lucidum showed 29% and 24% viability of cells against HT‐29 and H‐1299 cell lines, respectively. This antiproliferative effect was in dose‐dependent manner, and the maximum inhibition was observed at 200 μg/ml. Mushrooms extracts were also found effective against clot lysis. The percentage of clot lysis was in the range of 27%–29%. The research would provide knowledge to the people of Pakistan about the importance of locally available commercial mushrooms and wild mushrooms for health improvement and prevention against different kinds of diseases.

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“…Óñòàíîâëåíî, ÷òî ðåàëèçàöèÿ àíòè-îêñèäàíòíîé àêòèâíîñòè êàðäåêàèìà ñâÿçàíà òàêaeå ñ åãî ñïîñîáíîñòüþ ñâÿçûâàòü èîíû ìåòàëëîâ ïåðåìåí-íîé âàëåíòíîñòè è òåì ñàìûì ïðåäîòâðàùàòü ðàçâèòèå ñâîáîäíîðàäèêàëüíûõ ðåàêöèé. Ïðè ýòîì Fe 2+ -õåëàòè-ðóþùàÿ àêòèâíîñòü êàðäåêàèìà è åãî êîìïîíåíòîâ êîððåëèðîâàëà ñ ñîäåðaeàíèåì ïîëèñàõàðèäîâ è îáó-ñëîâëåíà, î÷åâèäíî, ïðèñóòñòâèåì â åãî ñîñòàâå Z. officinalis è E. Cardamonum, îáëàäàþùèõ äàííûì âèäîì àêòèâíîñòè [10]. Êðîìå òîãî, áèîëîãè÷åñêè àê-òèâíûå ñîåäèíåíèÿ, âõîäÿùèå â ñîñòàâ èñïûòóåìîãî ñðåäñòâà, îêàçûâàþò îïîñðåäîâàííîå àíòèîêèñëèòåëü-íîå äåéñòâèå, âûðàaeàþùååñÿ â ñïîñîáíîñòè çàùè-ùàòü îò îêèñëèòåëüíîé äåñòðóêöèè âàaeíåéøèå ýíäî-ãåííûå ñîåäèíåíèÿ, ó÷àñòâóþùèå â àíòèîêñèäàíòíîé çàùèòå: ÑÎÄ, êàòàëàçó è òèîëîâûå ñîåäèíåíèÿ, ñïî-ñîáñòâóÿ òåì ñàìûì ïîâûøåíèþ àíòèîêèñëèòåëüíîé çàùèòû îðãàíèçìà.…”

Section: ðåçóëüòàòû è èõ îáñóAeäåíèåunclassified

Стресс-Протекторная Активность Комплексного Растительного Средства «кардекаим» На Модели Иммобилизационного Стресса

Шантанова¹,

Алексеева²,

Торопова³

et al. 2015

Эксп. и клин. фармакол.

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Â îïûòàõ íà ýêñïåðèìåíòàëüíûõ aeèâîòíûõ èçó÷åíî âëèÿíèå ïðåâåíòèâíîãî êóðñî-âîãî ââåäåíèÿ ïðåïàðàòà ðàñòèòåëüíîãî ïðîèñõîaeäåíèÿ "êàðäåêàèì" íà îñíîâíûå ïðî-ÿâëåíèÿ ñòðåññà. Â îïûòàõ in vitro èçó÷åíû ìåõàíèçìû àíòèñòðåññîðíîãî ýôôåêòà òåñ-òèðóåìîãî ïðåïàðàòà. Êóðñîâîå ïðåâåíòèâíîå ââåäåíèå êàðäåêàèìà â äîçå 100 ìã/êã 7 äíåé ïåðåä îñòðûì èììîáèëèçàöèîííûì ñòðåññîì îêàçûâàåò âûðàaeåííîå ñòðåññ-ïðî-òåêòîðíîå äåéñòâèå, ïðåïÿòñòâóÿ ðàçâèòèþ ïðèçíàêîâ "òðèàäû Ñåëüå" íà 15 -63 % (ð < 0,05). Ïðåîáëàäàþùèì ìîëåêóëÿðíî-êëåòî÷íûì ìåõàíèçìîì ñòðåññ-ïðîòåêòîðíî-ãî äåéñòâèÿ êàðäåêàèìà ÿâëÿåòñÿ èíãèáèðîâàíèå ïðîöåññîâ ïåðåêèñíîãî îêèñëåíèÿ ëèïèäîâ, ÷òî îáóñëîâëåíî íàëè÷èåì ñîåäèíåíèé ôåíîëüíîé ïðèðîäû, îáëàäàþùèõ ïðÿìûì àíòèðàäèêàëüíûì äåéñòâèåì è ïîâûøàþùèõ ìîùíîñòü ýíäîãåííîé àíòèîê-ñèäàíòíîé ñèñòåìû.Êëþ÷åâûå ñëîâà: ôèòîïðåïàðàòû; êàðäåêàèì; àíòèñòðåñîðíîå äåéñòâèå; êðûñû; àíòè-îêñèäàíòû. ÂÂÅÄÅÍÈÅØèðîêîå ðàñïðîñòðàíåíèå ñòðåññ-èíäóöèðîâàííîé ïàòîëîãèè â ñîâðåìåííûõ óñëîâèÿõ äèêòóåò íåîáõîäè-ìîñòü ïîèñêà è ðàçðàáîòêè ýôôåêòèâíûõ è áåçîïàñíûõ ëåêàðñòâåííûõ ñðåäñòâ, ñïîñîáíûõ ïîâûøàòü àäàïòà-öèîííûå âîçìîaeíîñòè îðãàíèçìà è îáåñïå÷èòü àäåê-âàòíûé óðîâåíü ôèçè÷åñêîé, ýìîöèîíàëüíîé è êîãíè-òèâíîé àêòèâíîñòè â ýêñòðåìàëüíûõ óñëîâèÿõ áåç ïî-âðåaeäàþùèõ ïîñëåäñòâèé äëÿ îðãàíèçìà [3,8]. Íàè-áîëåå ïåðñïåêòèâíûì íàïðàâëåíèåì ðåøåíèÿ ýòîé ïðîáëåìû ÿâëÿåòñÿ ðàçðàáîòêà àäàïòîãåííûõ ñðåäñòâ íà îñíîâå ñûðüÿ ðàñòèòåëüíîãî ïðîèñõîaeäåíèÿ, îáëà-äàþùèõ ðÿäîì ïðåèìóùåñòâ ïåðåä ñèíòåòè÷åñêèìè ïðåïàðàòàìè. Ðàñòèòåëüíûå ñðåäñòâà ïðåäñòàâëÿþò êîìïëåêñû áèîëîãè÷åñêè àêòèâíûõ âåùåñòâ, êîòîðûå áëèçêè ïî ïðèðîäå ýíäîãåííûì ñîåäèíåíèÿì îðãàíèç-ìà, îêàçûâàþò àäåêâàòíîå êîððèãèðóþùåå äåéñòâèå íà ðàçíûõ óðîâíÿõ áèîëîãè÷åñêîé îðãàíèçàöèè; îáëàäà-þò øèðîêèì ñïåêòðîì ôàðìàêîëîãè÷åñêîé àêòèâíî-ñòè; õàðàêòåðèçóþòñÿ íèçêîé òîêñè÷íîñòüþ è îòñóòñò-âèåì íåáëàãîïðèÿòíûõ ïîáî÷íûõ ðåàêöèé ïðè äëè-òåëüíîì ïðèåìå. Â ñâÿçè ñ ýòèì íàìè ðàçðàáîòàí êîì-ïëåêñíûé ïðåïàðàò íà îñíîâå ñûðüÿ 4 âèäîâ ðàñòåíèé: Inula helenium L., Zingiber officinale Roscoe, Elletaria cardamomum (L.) Maton., Caragana spinosa, (L.) Wall. ex Hornem, óñëîâíî íàçâàííûé "êàðäåêàèì". Îñíîâà-íèåì äëÿ âûáîðà êîìïîíåíòîâ ïîñëóaeèëà ðåöåïòóðíàÿ ïðîïèñü, îïèñàííàÿ â òèáåòñêîì ñáîðíèêå "Êóí-ïàí-äóäçè" [7].Öåëüþ èññëåäîâàíèÿ ÿâèëîñü îïðåäåëåíèå ñòðåññ-ïðîòåêòîðíîé àêòèâíîñòè êàðäåêàèìà íà ìîäåëè èì-ìîáèëèçàöèîííîãî ñòðåññà è îöåíêà åãî àíòèîêñèäàíò-íîé àêòèâíîñòè. ÌÅÒÎÄÛ ÈÑÑËÅÄÎÂÀÍÈßÊàðäåêàèì ïðåäñòàâëÿåò ñîáîé ñóõîé ýêñòðàêò, ïî-ëó÷åííûé èç 4 âèäîâ ðàñòèòåëüíîãî ñûðüÿ: êîðíåâèù Inula helenium L., Zingiber officinale Roscoe, ïëîäîâ Elletaria cardamomum (L.) Maton. è ïîáåãîâ Caragana spinosa, (L.) Wall. ex Hornem. Òåõíîëîãèÿ ïîëó÷åíèÿ ñóõîãî ýêñòðàêòà âêëþ÷àåò òðåõêðàòíóþ ýêñòðàêöèþ ôèòîìèêñà ñ ïðåäâàðèòåëüíîé óëüòðàçâóêîâîé îáðà-áîòêîé ñìåñè, êîíöåíòðèðîâàíèå, âàêóóìíóþ ñóøêó è äîïîëíèòåëüíîå ââåäåíèå â ãîòîâûé ñóõîé ýêñòðàêò ýôèðíîãî ìàñëà.Èññëåäîâàíèå õèìè÷åñêîãî ñîñòàâà ñóõîãî ýêñòðàê-òà êàðäåêàèì ñ ïðèìåíåíèåì ÓÔ-ñïåêòðîñêîïèè, ÂÝÒÑÕ, ÂÝAEÕ è ÃÕ/ÌÑ âûÿâèëî ïðèñóòñòâèå îëè-ãîôðóêòàíîâ, ïîëèñàõàðèäîâ, ôëàâîíîèä...

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Antioxidant activities of polysaccharides from Lentinus edodes and their significance for disease prevention

Cited by 106 publications

References 29 publications

Extraction optimization of antioxidant polysaccharides from Auricularia auricula fruiting bodies

Extraction optimization of antioxidant polysaccharides from Auricularia auricula fruiting bodies

Anticancer, antithrombotic, antityrosinase, and anti‐α‐glucosidase activities of selected wild and commercial mushrooms from Pakistan

Стресс-Протекторная Активность Комплексного Растительного Средства «кардекаим» На Модели Иммобилизационного Стресса

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