Antioxidant activities of Pistacia atlantica extracts modeled as a function of chromatographic fingerprints in order to identify antioxidant markers

Ahmed, Ziyad Ben; Yousfi, Mohamed; Viaene, Johan; Dejaegher, Bieke; Demeyer, Kristiaan; Mangelings, Debby; Heyden, Yvan Vander

doi:10.1016/j.microc.2016.04.023

Cited by 34 publications

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References 39 publications

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“…2008 ; Ben Ahmed et al. 2016 ). The widespread use of P. atlantica in traditional medicine can be partly attributed to the content of the phenolic compounds.…”

Section: Introductionmentioning

confidence: 99%

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Seasonal, gender and regional variations in total phenolic, flavonoid, and condensed tannins contents and in antioxidant properties fromPistacia atlanticassp. leaves

Ahmed

Yousfi

Viaene

et al. 2017

Pharmaceutical Biology

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Context: The widespread use of Pistacia atlantica Desf. ssp. (Anacardiaceae) in traditional medicine can be partly attributed to the content of its secondary metabolites, in particular, the phenolic compounds.Objective: The effects of harvest period, growing region and gender on the phenolic compounds, flavonoids and condensed tannins contents were studied, as well as on the antioxidant activities of P. atlantica leaves in order to provide a scientific basis for optimal collection.Materials and methods: Leaves were collected monthly from April to October 2010 in two Algerian sites. The powdered leaves were used for preparing the ethyl acetate extract. Contents of total phenolics (TPC), flavonoids (FC) and condensed tannins (CTC) were determined spectrophotometrically. Antioxidant activity was evaluated through radical scavenging activity (RSA) of 2,2-diphenyl-1-picrylhydrazyl (250 μM) and the reducing power capacity (RPC) determination by K3Fe(CN)6 (1%).Results: The TPC was found to vary from 79 ± 13 to 259 ± 8 mg gallic acid equivalents/g of dry weight (DW) during the study period. The RSA and RPC varied between 262 ± 18 and 675 ± 21 mg Ascorbic Acid Equivalent (AAE)/g DW, and from 259 ± 16 to 983 ± 20 mg AAE/g DW, respectively. A seasonal pattern was observed consisting of a decrease in TPC content and RPC from spring to autumn. The FC, CTC and RSA did not show a seasonal pattern.Discussion and conclusion: Our findings showed that secondary metabolite content and antioxidant activities of P. atlantica leaves were more influenced by harvest time and growing region than by gender.

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“…2008 ; Ben Ahmed et al. 2016 ). The widespread use of P. atlantica in traditional medicine can be partly attributed to the content of the phenolic compounds.…”

Section: Introductionmentioning

confidence: 99%

“…Although the phenolic composition of P. atlantica leaves is reported (Ben Ahmed et al. 2016 ), there is little or no knowledge among local cultivators for choosing the optimal harvest time associated, for instance, with a maximal potency in antioxidant capacity.…”

Section: Introductionmentioning

confidence: 99%

Seasonal, gender and regional variations in total phenolic, flavonoid, and condensed tannins contents and in antioxidant properties fromPistacia atlanticassp. leaves

Ahmed

Yousfi

Viaene

et al. 2017

Pharmaceutical Biology

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“…And in agreement with Kocyigit et al [65 ], Sheridan et al [66] ; Kay et al [67] as they demonstrated that pistachio has a beneficial effect on the improvementof aminotransferase levels and blood lipid profile, This can be attributed to the existence of ellagitannins hydrolysable polyphenols as a highly antioxidant compounds, similar to that in pomegranate.In addition to other antioxidants that can effectively play a key role in stopping oxidative reactions in chains such as fatty acids, flavonoids and phenolic compounds. [32,33] tocopherols, carotenes, lutein, selenium and phytoestrogens [68,69].…”

Section: Discussionmentioning

confidence: 99%

“…Pistaciaatlantica has been shown to have antibacterial properties and is used in eczema, throat infections, kidney stones, asthma and stomach aches as an astringent, antipyretic, antiinflammatory, antiviral, and stimulating agent [32] . Previous studies of Photochemistry and chromatographic fingerprints of this plant indicated that it contain phenolic compounds (such as gallic acid, quinic acid, tetragalloylquinic acid,) and triterpenoids, pinene, terpinolene [33] .Although the pistachio is common, it was not sufficiently investigated as a safe eaten nut [34]. The use of nanoparticles science is completely exhibit an improved novel properties compared with larger particles of the bulk materials due to the variations in the particles size, morphology and distribution.…”

Section: Introductionmentioning

confidence: 99%

The Conquering influence of the Nano extracts of pomegranate peels and pistachio leaves in amelioration of acute liver failure

Hassan¹,

Hammam

Awadallah³

et al. 2020

Preprint

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ObjectiveAcute liver failure (ALF) is a clinical condition with an unclear history of pathophysiology, making it a challenging task for scientists to reverse the disease in its initial phase and to help the liver re-function as usual: this study was proposed to estimate the hepatoprotective effects of Punicagranatum peel and Pistaciaatlantica leaves as a multi-rich antioxidants ingredients either in their normal and/or in their nano forms against thioacetamide induced acute liver failure in a rodent model.MethodSixty male Wistar rats were divided into six equal groups, the first group employed as a control; the second group was given a dose of thioacetamide (TAA)-350 mg/bwip., from the third to the sixth group received TAA □ 2ml of 100gm of aqueous extracts of PunicagranatumL and Pistaciaatlantica either in their normal and/or Nano forms consecutively along 2 weeks.Resultsrecorded significant elevation in liver enzymes, lipid profiles, LPO and NO with marked significant decrease in GSH and SOD accompanied by elevation in inflammatory cytokine (IL6,TNF-α and AFP) in addition to a noticeable increase in HSP70 level & degradation in DNA respectively in TAA challenged group. However significant and subsequent amelioration of most of the impaired markers has been observed with ipnano treatment of both extracts.ConclusionThe current results highlighted the high performance of both plant nano extracts and their hepatoprotective impact and their possible therapeutic role in the amelioration of TAA induced acute liver failure in experimental animals.

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“…Among them, HPLC was the most commonly used method due to its simplicity, robustness, and durability [17]. However, a chromatographic fingerprint often contains highly complex multivariate data that make minor differences between similar chromatograms being easily ignored [18]. Thus, in order to simplify complex data and find hidden information behind the fingerprints, chemical pattern recognition (CPR) has been introduced to effectively and comprehensively evaluate the quality of TCMs.…”

Section: Introductionmentioning

confidence: 99%

High‐performance liquid chromatography–based fingerprint analysis with chemical pattern recognition for evaluation of Mahonia bealei (Fort.) Carr

Huang

Wang

Yin

et al. 2020

J of Separation Science

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A simple and efficient high‐performance liquid chromatography method combined with chemical pattern recognition was established for quality evaluation of Mahonia bealei (Fort.) Carr. A common pattern of 30 characteristic peaks was applied for similarity analysis, hierarchical cluster analysis, principal component analysis, and partial least squares discriminant analysis in the 37 batches of M. bealei (Fort.) Carr. to discriminate wild M. bealei (Fort.) Carr., cultivated M. bealei (Fort.) Carr., and its substitutes. The results showed that partial least squares discriminant analysis was the most effective method for discrimination. Eight characteristics peaks with higher variable importance in projection values were selected for pattern recognition model. A permutation test and 26 batches of testing set samples were performed to validate the model that was successfully established. All of the training and testing set samples were correctly classified into three clusters (wild M. bealei (Fort.) Carr., cultivated M. bealei (Fort.) Carr., and its substitutes) based on the selected chemical markers. Moreover, 26 batches of unknown samples were used to predict the accuracy of the established model with a discrimination accuracy of 100%. The obtained results indicated that the method showed great potential application for accurate evaluation and prediction of the quality of M. bealei (Fort.) Carr.

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Antioxidant activities of Pistacia atlantica extracts modeled as a function of chromatographic fingerprints in order to identify antioxidant markers

Cited by 34 publications

References 39 publications

Seasonal, gender and regional variations in total phenolic, flavonoid, and condensed tannins contents and in antioxidant properties fromPistacia atlanticassp. leaves

Seasonal, gender and regional variations in total phenolic, flavonoid, and condensed tannins contents and in antioxidant properties fromPistacia atlanticassp. leaves

The Conquering influence of the Nano extracts of pomegranate peels and pistachio leaves in amelioration of acute liver failure

High‐performance liquid chromatography–based fingerprint analysis with chemical pattern recognition for evaluation of Mahonia bealei (Fort.) Carr

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