Antioxidant activities of extracts and flavonoid compounds from<b><i>Oxytropis falcate</i></b>Bunge

Jiang, Heng; Zhan, W Q; Liu, X; Jiang, Shidong

doi:10.1080/14786410701875686

Cited by 57 publications

(22 citation statements)

References 10 publications

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“…Sakuranetin is the major flavonoid found in rice [45] and it has been primarily studied for its anti-inflammatory [46], anti-diabetic [47], and anti-bacterial [48] properties. Rhamnetin is found in most buckthorns (rhamnus genus) [49] and has been primarily studied for its anti-cancer [50], antioxidant [51] and anti-inflammatory properties [41]. Thus, both rhamnetin and sakuranetin have been found to be anti-inflammatory.…”

Section: Discussionmentioning

confidence: 99%

A nicotinic receptor-mediated anti-inflammatory effect of the flavonoid rhamnetin in BV2 microglia

et al. 2014

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The alpha7 nicotinic acetylcholine receptor (nAChR) is a potential target in neuroinflammation. Screening a plant extract library identified Solidago nemoralis as containing methyl-quercetin derivatives that are relatively selective ligands for the alpha7 nAChR. Flavonoids are not known for this activity, so we screened a small library of pure flavonoids to confirm our findings. Some flavonoids, e.g. rhamnetin, displaced a selective alpha7 nAChR radioligand from rat brain membranes whereas similar structures e.g. sakuranetin, did not. To evaluate the contribution of this putative nAChR activity to the known anti-inflammatory properties of these flavonoids, we compared their effects on lipopolysaccharide induced release of inflammatory mediators from BV2 microglia. Both rhamnetin and sakuranetin reduced mediator release, but differed in potency (rhamnetin>sakuranetin) and the Hill slope of their concentration response curves. For rhamnetin the Hill coefficient was >3.0 whereas for sakuranetin the coefficient was 1.0, suggesting that effects of rhamnetin are mediated through more than one mechanism, whereas sakuranetin has a single mechanism. nACHR antagonists decreased the Hill coefficient for rhamnetin toward unity, which suggests that a nAChR-mediated mechanism contributes cooperatively to its overall anti-inflammatory effect. In contrast nAChR antagonists had no effect on the potency or Hill coefficient for sakuranetin, but a concentration of nicotine (1μM) that had no effect alone, significantly increased the Hill coefficient of this flavonoid. In conclusion, the anti-inflammatory effects of rhamnetin benefit cooperatively from a nAChR-mediated mechanism. This action, together with potent free radical scavenging activity, suggests that flavonoids with alpha7 nAChR activity have therapeutic potential in neuroinflammatory conditions.

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Section: Discussionmentioning

confidence: 99%

A nicotinic receptor-mediated anti-inflammatory effect of the flavonoid rhamnetin in BV2 microglia

et al. 2014

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“…Many studies have showed the importance of their antiradical activity [10-13]. Moreover, their actions in humans have been subject of extensive research, and natural flavonoids have been described to possess several biological activities such as antioxidant, anti-inflammatory, antitumor, and antiviral properties [14].…”

Section: Introductionmentioning

confidence: 99%

Nanostructured Systems Containing Rutin: In Vitro Antioxidant Activity and Photostability Studies

et al. 2010

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The improvement of the rutin photostability and its prolonged in vitro antioxidant activity were studied by means of its association with nanostructured aqueous dispersions. Rutin-loaded nanocapsules and rutin-loaded nanoemulsion showed mean particle size of 124.30 ± 2.06 and 124.17 ± 1.79, respectively, polydispersity index below 0.20, negative zeta potential, and encapsulation efficiency close to 100%. The in vitro antioxidant activity was evaluated by the formation of free radical ·OH after the exposure of hydrogen peroxide to a UV irradiation system. Rutin-loaded nanostructures showed lower rutin decay rates [(6.1 ± 0.6) 10−3 and (5.1 ± 0.4) 10−3 for nanocapsules and nanoemulsion, respectively] compared to the ethanolic solution [(35.0 ± 3.7) 10−3 min−1] and exposed solution [(40.1 ± 1.7) 10−3 min−1] as well as compared to exposed nanostructured dispersions [(19.5 ± 0.5) 10−3 and (26.6 ± 2.6) 10−3, for nanocapsules and nanoemulsion, respectively]. The presence of the polymeric layer in nanocapsules was fundamental to obtain a prolonged antioxidant activity, even if the mathematical modeling of the in vitro release profiles showed high adsorption of rutin to the particle/droplet surface for both formulations. Rutin-loaded nanostructures represent alternatives to the development of innovative nanomedicines.

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“…The compounds were identified as quercetin (Zheng et al 2009), rutin (Marta et al 2016), verbascoside (Cao et al 2016), genistin (Yin et al 2013), kaempferol (Jiang et al 2008), isorhamnetin (Zheng et al 2009) and naringin (Xu et al 2015), respectively, by comparing the spectroscopic data with those of published values (Supplementary material).…”

Section: Structure Elucidation and Identificationmentioning

confidence: 99%

Structures and bioactivities of seven flavonoids from Osmanthus fragrans ‘Jinqiu’ essential oil extraction residues

Zhou

Fang

Wang

et al. 2017

Natural Product Research

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Osmanthus fragrans are well-known for their fragrance, but it is wasteful if to discard O. fragrans flower after extracting their essential oils. In this paper, we found that O. fragrans flower residues were rich in flavonoids. Six flavonoids and one phenylethanoid glycoside were isolated from the ethanol extract of O. fragrans flower residues, identified as quercetin (1), rutin (2), verbascoside (3), genistin (4), kaempferol (5), isorhamnetin (6) and naringin (7). In bioactivity study, kaempferol (IC = 1.43 μg/mL) showed the best anti-inflammatory activity. Isorhamnetin, quercetin, kaempferol, verbascoside and rutin (the values of IC were 18.30, 11.05, 16.88, 20.21 and 22.76 μg/mL, respectively) showed excellent DPPH free radical scavenging activity. Verbascoside performed relatively well at inhibiting the growth of both CT26 colonic carcinoma cells (IC = 46.87 μg/mL) and HepG2 hepatocarcinoma cells (IC = 30.58 μg/mL). In addition, quercetin and kaempferol showed strong anti-proliferation activity against HepG2 cells.

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Antioxidant activities of extracts and flavonoid compounds fromOxytropis falcateBunge

Cited by 57 publications

References 10 publications

A nicotinic receptor-mediated anti-inflammatory effect of the flavonoid rhamnetin in BV2 microglia

A nicotinic receptor-mediated anti-inflammatory effect of the flavonoid rhamnetin in BV2 microglia

Nanostructured Systems Containing Rutin: In Vitro Antioxidant Activity and Photostability Studies

Structures and bioactivities of seven flavonoids from Osmanthus fragrans ‘Jinqiu’ essential oil extraction residues

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