Antiosteoporotic activity of Salvadora persica sticks extract in an estrogen deficient model of osteoporosis

Fouda, Abdel-Motaal; Youssef, Amany R.

doi:10.1016/j.afos.2017.07.002

Cited by 15 publications

(11 citation statements)

References 29 publications

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“…One kg of SP roots was cut into small pieces, air dried, and ground into fine powder and then extracted in distilled water for 48 h at 25°C. After centrifugation at 1435 ×g for 15 min, the resulting supernatants were filtered through Whatman number 1 filter paper and the filtrates were concentrated using a rotary evaporator at 40°C [ 21 ]. The obtained fine extract powder was subdivided into small portions in brown bottles and freshly prepared before supplementation to rats.…”

Section: Methodsmentioning

confidence: 99%

Protective Effects of Miswak (Salvadora persica) against Experimentally Induced Gastric Ulcers in Rats

Lebda

El‐Far

Noreldin

et al. 2018

Oxidative Medicine and Cellular Longevity

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Gastric ulcers are among the most broadly perceived illnesses affecting individuals. Alcohol consumption is the main cause of gastric ulceration. This study assessed the protective effects of Salvadora persica (SP) extract against ethanol-induced gastric ulcer and elucidated the conceivable underlying mechanisms involved. For this purpose, 40 rats were allotted into 4 equal groups (control, ethanol- (EtOH-) treated, and SP-treated “SP200 and SP400” groups). The control and EtOH-treated groups were given phosphate buffer saline (PBS), and both the SP200 and SP400 groups were given SP extract dissolved in PBS at doses of 200 and 400 mg/kg b.w., respectively. All treatments were given orally for 7 constitutive days. On the 8th day, all rats were fasted for 24 h followed by oral gavage of PBS in the control group and chilled absolute ethanol solution (5 ml/kg b.w.) in the EtOH- and SP-treated groups to induce gastric lesions. One hour later, the rats were sacrificed and the stomachs were harvested. Gross and microscopic examinations of the EtOH-treated group showed severe gastric hemorrhagic necrosis, submucosal edema, destruction of epithelial cells, and reduced glycoprotein content at the mucus surface. These pathological lesions were defeated by SP extract treatment. Administration of SP extract modulated the oxidative stress and augmented the antioxidant defenses. The elevated ethanol-expressed tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) genes, as well as bcl-2-like protein 4 (Bax) and inducible nitric oxide synthase (iNOS), were diminished in the SP-treated group. Curiously, SP extract upregulated endothelial nitric oxide synthase (eNOS) and transforming growth factor-β1 (TGF-β1) gene expression comparable to that of the EtOH-treated rats. Aggregately, SP exerted antiulcer activities in ethanol-induced gastric ulcer rat models via modulation of oxidant/antioxidant status, mitigation of proinflammatory cytokines, and apoptosis, as well as remodeling of both NOS isoforms.

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Section: Methodsmentioning

confidence: 99%

Protective Effects of Miswak (Salvadora persica) against Experimentally Induced Gastric Ulcers in Rats

Lebda

El‐Far

Noreldin

et al. 2018

Oxidative Medicine and Cellular Longevity

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Section: Regenerative and Stem Cell Modulationmentioning

confidence: 99%

“…[ 31 , 120 , 121 ]. Among these studies, SP demonstrated a variety of effects that may influence periodontal therapy and play a role in improved regeneration and healing [ 51 , 62 , 67 , 122 , 123 ]. As elucidated in the studies [ 67 ], SP could activate transforming growth factor-β1 expression, promoting regenerative and stem cell functions, including self-renewal and differentiation, adhesion, proliferation and migration, angiogenesis, as well as production of extracellular matrix components [ 67 , 124 ].…”

Section: Modes Of Action Of Salvadora Persica As Potential Adjuncts During Periodontal Therapy and In Periodontitis-asmentioning

confidence: 99%

Salvadora persica: Nature’s Gift for Periodontal Health

Mekhemar

Geib²,

Kumar

et al. 2021

Antioxidants

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Salvadora persica (SP) extract, displays very valuable biotherapeutic capacities such as antimicrobial, antioxidant, antiparasitic and anti-inflammatory effects. Numerous investigations have studied the pharmacologic actions of SP in oral disease therapies but its promising outcomes in periodontal health and treatment are not yet entirely described. The current study has been planned to analyze the reported effects of SP as a support to periodontal therapy to indorse regeneration and healing. In consort with clinical trials, in vitro investigations show the advantageous outcomes of SP adjunctive to periodontal treatment. Yet, comprehensive supplementary preclinical and clinical investigations at molecular and cellular levels are indispensable to reveal the exact therapeutic mechanisms of SP and its elements for periodontal health and therapy.

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“…S. persica stick extract efficacy in an ovary-ectomized rat model of osteoporosis was investigated by ( Fouda and Youssef, 2017 ) . The extract was taken p.o., at doses of 50, 150, and 300 mg/kg, dissolved in of distilled water to ovary-ectomized female Sprague–Dawley rats every morning for 16 weeks.…”

Section: Health Benefits Of the Plant And Its Extractsmentioning

confidence: 99%

Salvadora persica L.: Toothbrush tree with health benefits and industrial applications – An updated evidence-based review

Farag

Abdel‐Mageed

Gamal

et al. 2021

Saudi Pharmaceutical Journal

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Salvadora persica L. is also known as Arak (in Arabic) and Peelu (in Urdu). Its frequent use as a toothbrush (miswak) is highly recommended by Prophet Muhammad. With a long history in folk medicine for centuries, S. persica was used in oral hygiene, food, cosmetics, fuel, and even as a medicine. Previous phytochemical investigation of its different parts afforded different classes of secondary metabolites such as flavonoids, glycosides, sterols, terpenes, carbohydrates and alkaloids. Organic sulfur-containing compounds and elemental sulfur are also present. In addition, there is a huge research on its biological potentials and industrial applications. Many pharmacological activities were reported experimentally, including antimicrobial, antioxidant, analgesic, anthelmintic, anti-inflammatory, antiulcer, sedative, anticonvulsant, anti-osteoporosis, antidiabetic, hypo-lipidemic, in addition to wound-healing, antidepressant and antitumor activities. Recently, a possible activity against COVID-19 protease was documented by molecular docking. This review tries to provide a recent detailed documentation of folk and modern uses of S. persica, focusing on the possible relations between its chemical constituents, pharmacological properties, and industrial applications. Moreover, a brief about recent analytical and validation methods for the major antimicrobial component is reported.

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Antiosteoporotic activity of Salvadora persica sticks extract in an estrogen deficient model of osteoporosis

Cited by 15 publications

References 29 publications

Protective Effects of Miswak (Salvadora persica) against Experimentally Induced Gastric Ulcers in Rats

Protective Effects of Miswak (Salvadora persica) against Experimentally Induced Gastric Ulcers in Rats

Salvadora persica: Nature’s Gift for Periodontal Health

Salvadora persica L.: Toothbrush tree with health benefits and industrial applications – An updated evidence-based review

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