Antiobesity effects of wild ginseng (<i>Panax ginseng</i> C.A. Meyer) mediated by PPAR‐<i>γ</i>, GLUT4 and LPL in ob/ob mice

Mollah, Mohammad Lalmoddin; Kim, Gi-Sang; Moon, Hye-Kyung; Chung, Sung Kwang; Cheon, Yong-Pil; Kim, Jong‐Kuk; Kim, Kil-Soo

doi:10.1002/ptr.2593

Cited by 50 publications

(42 citation statements)

References 25 publications

(22 reference statements)

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“…And, it has been variable effects on expression and activity of PPARc. Some studies have reported that ginseng increases the PPARc mRNA expression in adipose tissue (Park et al 2005;Mollah et al 2009) and in some studies, it decreases. For instance, ginsenoside Rb1, Rg1, Rg3 and Rh2 decreased the lipid accumulation and PPARc mRNA expression levels in 3T3-L1 adipocytes (Hwang et al 2007;Park et al 2008;Hwang et al 2009), and ginsenoside Rh2 and Rg3 have been reported as an antagonist for PPARc (Hwang et al 2007;Hwang et al 2009).…”

Section: Discussionmentioning

confidence: 99%

Effects of Korean white ginseng extracts on obesity in high-fat diet-induced obese mice

et al. 2010

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The present study examined the antiobesity effect and mechanism of action of Korean white ginseng extracts (KGE) using high-fat diet (HFD)-induced obese mice. Mice were fed a low-fat diet (LFD), HFD or HFD containing 0.8 and 1.6% (w/ w) KGE diet (HFD ? 0.8KGE and HFD ? 1.6KGE) for 8 weeks. We also examined the effects of KGE on plasma triglyceride (TG) elevation in mice administrated with oral lipid emulsion. Body weight gain and white adipose tissue (WAT) weight were significantly decreased in the HFD ? 1.6KGE group, compared with the HFD group. The plasma TG levels were also significantly reduced in both HFD ? 0.8KGE and HFD ? 1.6KGE groups, while leptin levels were significantly decreased in only the HFD ? 1.6KGE group, compared with the HFD group. The HFD ? 1.6KGE group showed significantly lower mRNA levels of lipogenesis-related genes, including peroxisome proliferator-activated receptorc2 (PPARc2), sterol regulatory element binding protein-1c (SREBP-1c), lipoprotein lipase (LPL), fatty acid synthase (FAS) and diacylglycerol acyltransferase 1 (DGAT1), compared with the HFD group. In addition, a dose of 1000 mg/kg KGE inhibited the elevation of plasma TG levels compared with mice given the lipid emulsion alone. These results suggest that the anti-obesity effects of KGE may be elicited by regulating expression of lipogenesis-related genes in WAT and by delaying intestinal fat absorption.

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Section: Discussionmentioning

confidence: 99%

Effects of Korean white ginseng extracts on obesity in high-fat diet-induced obese mice

et al. 2010

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“…Wild ginseng leaf extract supplementation to diabetic rats helps to control their blood glucose levels [17]. We have previously reported that the anti-obesity effects of wild ginseng mediated PPARγ, Glucose transporter type 4 (GLUT4) and Lipoprotein lipase (LPL) in ob/ob mice [18]. The present study showed that CWG suppresses adipocyte differentiation by inhibiting the expression of adipogenic genes.…”

Section: Discussionmentioning

confidence: 49%

Inhibitory Effects of Cultivated Wild Ginseng on the Differentiation of 3T3-L1 Pre-adipocytes

Mollah¹,

Cheon²,

In³

et al. 2011

Journal of Ginseng Research

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Wild ginseng has been used as a traditional medicine for thousands of years and for increase physical strength in Korea, China and Japan. This study reports that cultivated wild ginseng (CWG) inhibits adipocyte differentiation of 3T3-L1 preadipocytes in a concentration-dependent manner. Inhibition of adipocyte differentiation is one possible anti-obesity strategy. CWG inhibits the expression of the adipocyte differentiation regulator peroxisome proliferators-activated receptor (PPAR)γ and CCAAT/enhancer-binding protein α mRNA. It also inhibited the expression of PPARγ and adiponectin at the protein level during the differentiation of pre-adipocytes into adipocytes. Additionally, CWG blocked the cell cycle at the sub-G 1 phase transition, causing cells to remain in the pre-adipocyte state. These results indicate that CWG inhibits adipocyte differentiation and adipogenesis through pre-adipocyte cell cycle arrest in cultured 3T3-L1 cells.

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“…Since obesity is an inflammatory condition, Panax ginseng effect can be also explained by a proven anti-inflammatory action (20) . In addition to its agonist action on PPARg receptors, Panax ginseng has also been proved to regulate the lipoprotein lipase expression in adipose tissue, as well as to play a role in the regulation of glucose transporter 4 (GLUT4) and insulin receptor in skeletal muscle and liver (24) . In the current experiment, one group of rats received Camellia sinensis extract (100 mg/kg/day) with 35% of catechins.…”

Section: Discussionmentioning

confidence: 99%

“…Experimental studies investigating the mechanisms of action of Panax ginseng and Camellia sinensis have been conducted in recent decades but most of them sought to assess qualitatively and quantitatively crude extracts and active principles alone (24) . The current study was carried out to compare the effectiveness of Panax ginseng and Camellia sinensis in disease prevention using biochemical and histopathological parameters.…”

Section: Ginseng Green Tea or Fibrate: Valid Options For Nonalcoholimentioning

confidence: 99%

GINSENG, GREEN TEA OR FIBRATE: valid options for nonalcoholic steatohepatitis prevention?

Miranda-Henriques

Diniz

Araújo

2014

Arq. Gastroenterol.

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-Objective -Panax ginseng, Camellia sinensis and bezafibrate were compared for their lipid-lowering, antioxidant and anti-inflammatory properties as potential agents to prevent nonalcoholic fatty liver disease and its progression to nonalcoholic steatohepatitis. Methods -Fifty Wistar rats were randomized into five groups: G1 (feed with standard diet); G2 (feed with high-fat diet with 58% of energy from fat); G3 (high-fat diet + standardized Panax ginseng extract at 100 mg/kg/day); G4 (high-fat diet + standardized Camellia sinensis extract at 100 mg/kg/day); and G5 (high-fat diet + bezafibrate at 100 mg/kg/day), given by gavage. The animals were sacrificed eight weeks later and blood was collected for glucose, insulin, cholesterol, triglycerides, AST, ALT, alkaline phosphatase and gamma-glutamyl transferase determinations. The score system for nonalcoholic fatty liver disease was used to analyse the liver samples. Results and Conclusions -High-fat diet resulted in a significant increase in animal body weight, biochemical changes and enzymatic elevations. Steatosis, inflammation and hepatocellular ballooning scores were significant high in this group. The biochemical and histological variables were statistically similar in the bezafibrate group and control group. Treatment with Panax ginseng extract prevented obesity and histological features of nonalcoholic steatohepatitis (steatosis and inflammation) compared to high-fat diet. Camellia sinensis showed a less effective biochemical response, with small reduction in steatosis and inflammation but lower ballooning scores. HEADINGS -Panax. Camellia sinensis. Liver diseases. Metabolic Syndrome X.

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Antiobesity effects of wild ginseng (Panax ginseng C.A. Meyer) mediated by PPAR‐γ, GLUT4 and LPL in ob/ob mice

Cited by 50 publications

References 25 publications

Effects of Korean white ginseng extracts on obesity in high-fat diet-induced obese mice

Effects of Korean white ginseng extracts on obesity in high-fat diet-induced obese mice

Inhibitory Effects of Cultivated Wild Ginseng on the Differentiation of 3T3-L1 Pre-adipocytes

GINSENG, GREEN TEA OR FIBRATE: valid options for nonalcoholic steatohepatitis prevention?

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