Antiobesity Effect of Citrus Peel Extract Fermented with Aspergillus oryzae

Abstract

There is a rising trend in obesity due to various factors, including changes in eating habits, lack of exercise, and genetic and psychological factors. Citrus peel has been reported to prevent obesity via antioxidative, antihypertensive, and LDL cholesterol-lowering effects. This study investigated the effects of citrus peel extract fermented with or without Aspergillus oryzae in a mouse model of diet-induced obesity. The animals were divided into four groups: a high-fat diet group (HFD), a normal fat diet (NFD) group, a citrus peel extract (CP) group, and a citrus peel extract fermented with A. oryzae (CPA) group. The citrus peel extract improved lipid metabolism and weight loss in the high-fat diet-induced obese mouse model. As expected, the body weight was higher in the HFD group compared with the NFD, CP, and CPA groups. However, the concentrations of total cholesterol (TG) and triglyceride (TC) in the serum and liver of the CP and CPA groups were lower than in the HFD group. There were no significant differences in the HDL cholesterol concentration among the groups. Taken together, our results suggest that extract of citrus peel biotransformed with A. oryzae had more antiobesity activity than citrus peel not transformed by A. oryzae through the fermentation of metabolites.

Extracts of Citrus Juice Processing Wastes Induce Weight Gain and Decrease Serum Glucose in Sprague-Dawley Rats

“…To solve the problems raised by these large amounts of CJPW, studies have attempted various methods to safely recycle CJPW without adversely affecting the en-vironment. CJPW is characterized by a high content of naringin and hesperidin, but is also rich in other bioflavonoids and carotenoids (Kim et al, 2006;Andrad et al, 2007;Jeon et al, 2014). Further, CJPW contains a large proportion of dietary fiber, which is known to lower blood cholesterol (Khan et al, 2021).…”