Antinuclear Antibodies in Localized Scleroderma

Takehara, Kazuhiko; Möroi, Y; Nakabayashi, Yasushi; Ishibashi, Yoshihiro

doi:10.1002/art.1780260506

Cited by 129 publications

(87 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Similarly, anti-ssDNA has been reported to be present in 70-80% of patients with drug-induced lupus, but anti-dsDNA is absent, despite the universal presence of AHA (10,15). In addition, patients with generalized morphea do not have the same autoantibodies as patients with SSc, and this is also the case for patients with drug-induced lupus and idiopathic SLE (3,10,15). Thus, the presence of both AHA and anti-ssDNA and the absence of anti-dsDNA are major characteristics of the immunologic abnormalities seen in both generalized morphea and drug-induced lupus.…”

Section: Discussionmentioning

confidence: 97%

“…However, the antigens that are recognized by the ANA in localized scleroderma remain to be determined. Antibodies to topoisomerase I, centromere, or U1 RNP, which are frequently detected in patients with systemic sclerosis, are with few exceptions, absent in this disease (3).…”

mentioning

confidence: 82%

“…ANA was detected by indirect immunofluorescence, on HEp-2 cell substrate, as described previously (3).…”

Section: Methodsmentioning

confidence: 99%

“…Previous studies have shown that ANA is detected in 4680% of patients with localized scleroderma, as tested with cultured cells, and that the most common pattern of nuclear immunofluorescence is homogeneous (3)(4)(5). However, the antigens that are recognized by the ANA in localized scleroderma remain to be determined.…”

mentioning

confidence: 98%

See 3 more Smart Citations

Antihistone antibodies in patients with localized scleroderma

Sato

Ihn

Soma

et al. 1993

Arthritis & Rheumatism

Self Cite

106

View full text Add to dashboard Cite

Objective. To study the prevalence and antigen specificity of antihistone antibodies (AHA) in localized scleroderma.Methods. Forty-nine serum samples from patients with localized scleroderma were examined by an enzyme-linked immunosorbent assay (ELISA) and by immunoblotting.Results. By ELISA, AHA were demonstrated in 47% (23 of 49) of patients with localized scleroderma and in 87% (13 of 15) of patients with generalized morphea. Immunoblotting revealed that the predominant antigens were histones H1 and H3. The presence of AHA correlated with that of anti-single-stranded DNA antibody.Conclusion. Some of the major antigens for antinuclear antibodies in patients with localized scleroderma are histones.Localized scleroderma is a connective tissue disorder that is limited to the skin and the subcutaneous tissues underlying the cutaneous lesions. This disease differs from systemic sclerosis in that it is not accompanied by Raynaud's phenomenon, acrosclerosis, or involvement of the internal organs, and the From the

show abstract

Section: Discussionmentioning

confidence: 97%

mentioning

confidence: 82%

“…ANA was detected by indirect immunofluorescence, on HEp-2 cell substrate, as described previously (3).…”

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 98%

See 2 more Smart Citations

Antihistone antibodies in patients with localized scleroderma

Sato

Ihn

Soma

et al. 1993

Arthritis & Rheumatism

Self Cite

106

View full text Add to dashboard Cite

show abstract

“…Antinuclear antibodies (ANA) were detected by immunofluorescence using HEp-2 cells as the substrate, and by double immunodiffusion for extractable nuclear antigens [19].…”

Section: Antinuclear Antibody Analysesmentioning

confidence: 99%

Measurement of anticardiolipin antibodies by ELISA using β2-glycoprotein I (β2-GPI) in systemic sclerosis

Ihn

Sato

Fujimoto

et al. 1996

Clinical and Experimental Immunology

View full text Add to dashboard Cite

SUMMARYIn order to determine the prevalence and clinical significance of¯2-GPI-dependent anticardiolipin antibodies (¯2-GPI/aCL) in patients with systemic sclerosis (SSc), serum samples from 80 patients with SSc, 20 patients with systemic lupus erythematosus (SLE), and 120 healthy control subjects were examined by ELISA using purified¯2-GPI. IgG isotype¯2-GPI/aCL was present in eight of 80 patients with SSc (10%), and the presence of¯2-GPI/aCL IgG was significantly correlated with the presence of isolated pulmonary hypertension (PH). Furthermore, levels of¯2-GPI/aCL IgG were significantly correlated with levels of mean pulmonary arterial pressure. These data suggest that IgG isotype¯2-GPI/ aCL might be a serological indicator of the severity of PH in patients with SSc.

show abstract

High Titers of Antibodies to Single-Stranded DNA in Linear Scleroderma

1985

Arch Dermatol

View full text Add to dashboard Cite

Antinuclear Antibodies in Localized Scleroderma

Cited by 129 publications

References 14 publications

Antihistone antibodies in patients with localized scleroderma

Antihistone antibodies in patients with localized scleroderma

Measurement of anticardiolipin antibodies by ELISA using β2-glycoprotein I (β2-GPI) in systemic sclerosis

High Titers of Antibodies to Single-Stranded DNA in Linear Scleroderma

Contact Info

Product

Resources

About