Antinociceptive principle from Curcuma aeruginosa

Hossain, Chowdhury Faiz; Al‐Amin, Mohammad; Sayem, Abu Sadat Md.; Siragee, Ismail Hossain; Tunan, Asif Mahmud; Hassan, Fahima; Kabir, Md. Mohiuddin; Sultana, Gazi Nurun Nahar

doi:10.1186/s12906-015-0720-6

Cited by 29 publications

(14 citation statements)

References 27 publications

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“…Germacrone showed anti-inflammatory [ 131 , 267 ], antiandrogenic [ 137 ], and antimicrobial [ 28 ] activities. Germacrone from C. aeruginosa has been shown to increase skin penetration of minoxidil [ 30 ].…”

Section: Bioactivity and Safety Of Individual Key Componentsmentioning

confidence: 99%

Chemical Composition and Biological Activities of Essential Oils of Curcuma Species

2018

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Members of the genus Curcuma L. have been used in traditional medicine for centuries for treating gastrointestinal disorders, pain, inflammatory conditions, wounds, and for cancer prevention and antiaging, among others. Many of the biological activities of Curcuma species can be attributed to nonvolatile curcuminoids, but these plants also produce volatile chemicals. Essential oils, in general, have shown numerous beneficial effects for health maintenance and treatment of diseases. Essential oils from Curcuma spp., particularly C. longa, have demonstrated various health-related biological activities and several essential oil companies have recently marketed Curcuma oils. This review summarizes the volatile components of various Curcuma species, the biological activities of Curcuma essential oils, and potential safety concerns of Curcuma essential oils and their components.

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Section: Bioactivity and Safety Of Individual Key Componentsmentioning

confidence: 99%

Chemical Composition and Biological Activities of Essential Oils of Curcuma Species

2018

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“…Preclinical studies on C. aeruginosa extracts (CA-ext) have revealed antimicrobial, anti-inflammatory, analgesic, and antipyretic actions [10-12]. Further to these, we demonstrated that the CA-ext rhizome inhibited S5αR in vitro and in vivo [13] due to its sesquiterpenes, of which germacrone was most potent [13].…”

Section: Introductionmentioning

confidence: 85%

Sesquiterpene-Enriched Extract of <b><i>Curcuma aeruginosa</i></b> Roxb. Retards Axillary Hair Growth: A Randomised, Placebo-Controlled, Double-Blind Study

Srivilai¹,

Nontakhot²,

Nutuan³

et al. 2018

Skin Pharmacol Physiol

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Background: Sesquiterpenes in Curcuma aeruginosa Roxb. inhibit steroid 5α-reductase and dihydrotestosterone production, and reverse androgenic alopecia. This study sought to show that a high sesquiterpene C. aeruginosa extract (CA-ext) retards axillary hair growth in women. Methods: Thirty women (age 20–52 years) were recruited into a 12-week, double-blind, placebo-controlled intervention for CA-ext treatment, where they were randomly allocated to a left or right armpit group. At weekly intervals, axillary hair length was measured videometrically, the hair was shaved, and lotion was applied (to the contralateral axilla) twice daily via roll-on applicators containing either CA-ext or placebo. The primary endpoint of the study was hair growth. Results: Participants showed 22% (range 8–56%, p < 0.0001) reduced axillary hair growth with CA-ext compared to placebo, albeit delayed by 6 weeks. Participants were satisfied with the treatment and no apparent adverse effects were reported. The quantities of lotion used for each axilla were identical between test and placebo throughout the trial for each participant. Participants reported having shorter and finer armpit hair with the test lotion but disliked its smell, even though it was perfumed. The “free of irritation” description gained the highest questionnaire ratings. Conclusion: CA-ext in lotion is an efficacious inhibitor of axillary hair growth, the preparation was well accepted and matched the effectiveness of finasteride. Thus, with some refinement, it should provide an alternative pharmacological treatment for unwanted androgenic hair.

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“…Curcuma aeruginosa is known in Indonesia as "temu ireng" and "pink and blue ginger" in English (Nurcholis et al 2012;Simoh and Zainal 2015). C. aeruginosa has been used as traditional medicine in South and Southeast Asia for gastrointestinal and uterine disorders or parasitic and fungal infection (Jose and Thomas 2014;Hossain et al 2015;Theanphong et al 2015). Sesquiterpenes have been found as common chemical constituents of C. aeruginosa (Suphrom et al 2012).…”

Section: Discussionmentioning

confidence: 99%

Tracheospasmolytic and anti-inflammatory activity of indigenous Curcuma species as traditional antiasthmatic medicines

et al. 2018

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Paramita S, Moerad EB, Ismail S, Marliana E. 2018. Tracheospasmolytic and anti-inflammatory activity of indigenous Curcuma species as traditional antiasthmatic medicines. Nusantara Bioscience 10: 105-110. Asthma is still a major health problem in the world. Antiasthma drugs raise the problem of side effects and medical expenses. Thus, it is necessary to develop medicinal plants based antiasthma drugs with fewer side effects and more affordable costs. The potential antiasthma medicinal plant came from the genus of Curcuma (Zingiberaceae family). Turmeric (Curcuma longa L.) is the most prominent species in this genus and has been extensively studied for the treatment of asthma. However, there are other Curcuma indigenous species that are also traditionally used for asthma, namely Curcuma aeruginosa Roxb. and Curcuma mangga Val. Zijp. Both indigenous species have not been studied pharmacological activity as an antiasthma. This research was conducted to know the tracheospasmolytic activity of ethanol extract of C. aeruginosa and C. mangga on the separate organ of guinea pig trachea to determine the antiasthma effect. The research was also conducted to know anti-inflammatory activity with membrane stabilization test and inhibition of lipoxygenase. Results showed that C. aeruginosa and C. mangga had lower tracheospasmolytic activity when they were compared with aminophylline as a positive control. However, the EC50 value of C. aeruginosa (0.020 ± 0.004) and C. mangga (0.039 ± 0.005) were not significantly different with aminophylline (0.016 ± 0.005) as positive controls. The result of membrane stabilization test showed that the EC50 value of C. aeruginosa (47.76 ± 1.57) and C. mangga (67.50 ± 0.97) were high when they were compared with indomethacin (26.39 ± 2.91) as the positive control. Results of lipoxygenase inhibition test showed that the EC50 value of C. aeruginosa (-111.11 ± 2.30) and C. mangga (-101.98 ± 1.32) were high than that of indomethacin (-282.84 ± 7.41) as the positive control. These results show the potential use of C. aeruginosa and C. mangga as antiasthma via tracheospasmolytic activity in separate organs of guinea pig. They also had anti-inflammatory effect based on membrane stabilization and inhibition of lipoxygenase test.

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Antinociceptive principle from Curcuma aeruginosa

Cited by 29 publications

References 27 publications

Chemical Composition and Biological Activities of Essential Oils of Curcuma Species

Chemical Composition and Biological Activities of Essential Oils of Curcuma Species

Sesquiterpene-Enriched Extract of <b><i>Curcuma aeruginosa</i></b> Roxb. Retards Axillary Hair Growth: A Randomised, Placebo-Controlled, Double-Blind Study

Tracheospasmolytic and anti-inflammatory activity of indigenous Curcuma species as traditional antiasthmatic medicines

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